2. Outline Definition & mechanism of shock. Consequences of Shock. How to diagnose shock? Classification of Shock. Causes of various types of shock Basic principles in management of shock.

3. Shock Reduction of effective tissue perfusion leading to cellular and circulatory dysfunction

4. Shock Medical emergencies if unrecognized or inadequately treated will result in high mortality

5. Shock Reduced Perfusion Brain Decreased mental status Myocardial Depression Kidney Oliguria Liver Increased liver enzymes Lung Hypoxemia Pheripheral Circulation Hypotension Heart

6. Shock The aim of perfusion is to achieve adequate Cellular Oxygenation This requires Red Cell Red Cell OxygenationDelivery To Tissues Fick Principle

7. Air’s gotta go in and out. Blood’s gotta go round and round. Any variation of the above is not a good thing!

9. Shock Red Cell Oxygenation 1. Oxygen delivery to alveoli Adequate F i O 2 Patent airways Adequate ventilation

10. Shock Red Cell Oxygenation 2. Oxygen exchange with blood Adequate oxygen diffusion into blood Adequate RBC capacity to bind O 2 –pH –Temperature

11. Shock Red Cell Delivery To Tissues 1. Adequate perfusion Blood volume Cardiac output –Heart rate –Stroke volume Conductance –Arterial resistance –Venous capacitance

12. Shock Red Cell Delivery To Tissues 2. Adequate RBC mass/Hgb levels Adequate RBC mass Adequate Hgb levels Adequate RBC capacity to unbind O 2 pH Temperature

13. Consequences of Shock Inadequate tissue perfusion: Poor cellular Shift from aerobic Oxygenation to anaerobic metabolism

14. ANAEROBIC METABOLISM GLUCOSEMETABOLISM 2 LACTIC ACID 2 ATP HEAT (32 kcal) Glycolysis: Inefficient source of energy production; 2 ATP for every glucose; produces pyruvic acid

15. AEROBIC METABOLISM 6 O 2 GLUCOSE METABOLISM 6 CO 2 6 H 2 O 36 ATP HEAT (417 kcal) Glycolysis: Inefficient source of energy production; 2 ATP for every glucose; produces pyruvic acid Oxidative phosphorylation: Each pyruvic acid is converted into 34 ATP

16. Anaerobic Metabolism Occurs without oxygen oxidative phosphorylation can’t occur without oxygen glycolysis can occur without oxygen cellular death leads to tissue and organ death can occur even after return of perfusion  organ dysfunction or death

17. Inadequate Cellular Oxygen Delivery Anaerobic Metabolism Inadequate Energy Production Metabolic Failure Lactic Acid Production Metabolic Acidosis CELL DEATH Ultimate Effects of Anaerobic Metabolism

18. Shock Markers Of Hypoperfusion ↑ Serum Lactate Metabolic acidosis Hypotension

19. Maintaining perfusion requires: Adequate Volume Normal Cardiac Function Normal Vessels Failure of one or more of these causes shock

20. Shock Syndromes ● Hypovolemic Shock - Blood volume problem ● Cardiogenic Shock - Blood pump problem ● ObstructiveShock - Filling Problem ● Distributive Shock - Blood vessels problem

21. Hypovolemic Shock Loss of Volume Blood loss ▪ Trauma ▪ Non-traumatic  Vaginal  GI  GU Fluid loss - Dehydration - Burns - Diarrhea - Vomiting - Diuresis - Sweating Third space losses  Pancreatitis  Peritonitis  Bowel obstruction

22. Shock Sign and Symptoms Brain Decreased mental status Kidney Oliguria Liver Increased liver enzymes Lung Hypoxemia Pheripheral Circulation  Hypotension  Cold Clammy skin

23. Key Issues In Shock Recognize & Treat during compensatory phase Best indicator of resuscitation effectiveness = Level of Consciousness Restlessness, anxiety, combativeness = Earliest signs of shock

24. Hypovolemic Shock Management Goal: Restore circulating volume, tissue perfusion & correct cause A B C Two large bore IV lines/central line Fluids / Blood & Products /vasopressors  Target arterial BP – SBP ≥ 90 mmHg  - MAP ≥65 mmHg. Bladder catheter Arterial Cannulation

25. Key Issues In Shock Tissue ischemic sensitivity Heart, brain, lung: 4 to 6 minutes GI tract, liver, kidney: 45 to 60 minutes Muscle, skin: 2 to 3 hours Resuscitate Critical Tissues First!

26. Consequence Of Volume Loss :  15%[750ml]- compensatory mechanism maintains cardiac output  15-30% [750-1500ml]-decreased BP & urine output  30-40% [1500-2000ml] -profound shock along with severe acidosis  40-50% - refractory stage

27. Shock Cardiogenic Shock = Pump Failure Myopathic M I CHF Cardiomyopathy Arrhythmic Tachy or bradyarrhythmias Mechanical Valvular Failure HOCM

28. Cardiogenic Shock History :  Chest pain, Palpitations,SOB  RHD,IHD Physical exam:  Signs of ventricular failure  Heart : Murmurs,S3,S4

29. Cardiogenic Shock  Treat rate, then rhythm, then BP  Correct bradycardia or tachycardia  Correct irregular rhythms  Treat BP ↑ Cardiac contractility (inotropes) –Dobutamine, Dopamine

30. Distributive Shock Inadequate perfusion of tissues due to mal-distribution of blood flow. ( blood vessels problem ) Cardiac pump & blood volume are normal but blood is not reaching the tissues.

31. Distributive Shock 1. Septic Shock 2. Anaphylactic Shock 3. Neurogenic/Vasogenic(spinal cord) 4. Endocrinologic

32. Septic Shock management A B C Assist ventilation & Augment Oxygenation Monitor Tissue perfusion- Restore Tissue perfusion- IV Fluids, Vasopressors Identification & Eradication of septic foci Specific Therapies -

33. Neurogenic Shock Patient supine; lower extremities elevated Avoid Trendelenburg Infuse isotonic crystalloid Maintain body temperature

34. Anaphylactic Shock  Antihistamines  Corticosteroids  Epinephrine  Isotonic fluid titrated to  BP ~ 90 mmHg

35. Obstructive shock Impaired diastolic filling Cardiac tamponade Constrictive pericarditis Tension pneumothorax  Increased ventricular afterload Pulmonary embolism

36. Obstructive Shock Treat the underlying cause Tension Pneumothorax Pericardial Tamponade Anticoagulation Isotonic fluids titrated to BP w/o pulmonary edema Control airway Intubation

37. Key Issues In Shock Falling BP = LATE sign of shock. BP is NOT same thing as perfusion. Pallor, tachycardia, slow capillary refill = hypoperfusion, until proven otherwise.

38. Shock Management Avoid vasopressors until hypovolemia ruled out, or corrected Squeezing partially empty tank can cause ischemia, necrosis of kidney and bowel