1. Endovascular Therapy for Acute Ischemic Stroke ML006 Rev01

2. Adapted from Goyal, Hill, Demchuk – ESCAPE, ISC 2015 Recent Anterior Circulation Trials Low ASPECTS good ASPECTS Poor collaterals good collaterals Large core small core 80y 12 h 6h 2h MR CLEAN ESCAPE EXTEND-IA SWIFT PRIME Time From Onset Patient Populations Included Revascula rization TICI 2b-3 Good Outcomes mRS0-2 MR CLEAN58.7%32.6% ESCAPE72.4%53% EXTEND- IA 86%71% SWIFT PRIME 88%61% Endovascular Treatment Results 2 ML006 Rev01

3. Lessons from Recent Trials LVO’s should be treated with IV t-PA plus thrombectomy Speed is critical Reperfusion Grade matters Room for Improvement 3 Fargen et al. J NeuroIntervent Surg 2013;5:506–511; Nogueira, TREVO2, The Lancet 2012; Saver, SWIFT, The Lancet 2012; Mendes Pereira, Stroke. 2013;44, Wahlgren et al, ISC 2012; Zaidat et al. J NeuroIntervent Surg 2013; ISC 2015 - ESCAPE, MR CLEAN, EXTEND-IA, SWIFT PRIME Why 20-25% not revascularized? ML006 Rev01

4. Clot property differences impact revascularization 4 Carotid Heart valve Atrium Example of Fresh Erythrocyte Clot Forming Occlusion ML006 Rev01

5. 5 Caution: for investigational use only Revascularization Device Outer cage Inner Channel Distal Protection Zone ML006 Rev01

6. EmboTrap Demonstration 6 ML006 Rev01 Caution: for investigational use only