2. Organic chemistry Faculty of Allied Medical Sciences (MGOC-101)

3. Supervision: Prof.Dr.Shehata El-Sewedy Dr. Fatma Ahmed

4. Outcomes By the end of this lecture, the students will be able to 1-Recognize physical properties for alcohol 2-Known nomenclature of aliphatic and aromatic alcohol 3- learn preparation of aliphatic and aromatic alcohol 4- known reaction of aliphatic and aromatic alcohol 5-Differentiate between aliphatic and aromatic alcohol 6- Understand the order of acidity

5. Alcohol as function group of alcohol ROH

6. Physical properties Alcohol soluble in polar solvent (H 2 O) Alcohol have high boiling point due to have intermolecular hydrogen bond So alcohol its boiling point higher than corresponding alkane, ether which have the same number of carbon ROH> R-H> R-O-R Alcohol Alkane ether

7. As number of OH group increase hydrogen bond increase, boiling point increase & viscosity increase.

8. Nomenclature 1-Common name Alkyl name+alcohol 2-IUPAC 1-Select the long continuous chain have OH as parent name (alkane alkanol) 2-Number from side near to OH group to give lowest number (position+alkanol) 3-Substitution its position& name write 4-Priority in numbering of groups -COOH>-CHO>-CO->-OH>alkene>alkyne>R

9. EX:

10. Preparation of alcohol 1-Reduction of carbonyl group

11. 2-By Grignard reagent

12. EX:

13. N.B

14. 3-Oxymercyrcation-Demercurcation of alkene

15. EX:

16. Reaction of alcohol 1-Oxidation of alcohol

17. 2-Esterification EX:

19. Nomenclature

20. Preparation of phenols From halobenzene

21. Reactions of phenols Ether formation Ex.

22. The order of acidity RCOOH ˃ Ar-OH ˃ HOH ˃ R-OH Phenol is more acidic than alcohols because:-

24. Quiz time

25. Complete:

26. Arrange for the order of acidity: R-OH - RCOOH - HOH - Ar-OH Convert: Chlorobenzene

27. Student Question

28. Write the nomenclature for the following compounds Write the chemical formula for the following compounds?

29. Assignments(1) Group A and Group B Samar Mostafa- Omnia Mosaad- Esraa Kamel- Reem khaled- Shrouk Essam Applications of glycerol Ahmad Rada Kamel – Ahmad Mohamad Abd El Salam- Ahmad El Said- Ahmad Alaa Oxidation of Alcohols Sara Lotfy- Shimaa Saied – Esraa Sameh-Ahmad Shadra-Ibrahim El-Habet- Ibrahim El Said Uses of Amines Aya Ibrahim – Shreen Hassan – Mohamad Ahmad Torky- Mohamad Montaser- Doaa Sabri Effect of Acetophenone on health Someya Mostafa – Maram Ahmad – Esraa Mahmoud Nucleophilic reaction Youssef AboBakr – Mina Melad – Omar Gamal Kamal Electrophilic reaction

30. Assignments(2) Group A and Group B Hanan Ahmad Zaid -Alfa Magdi - Alaa Kamal Anani – Asmaa Mohamad El-Awadi- Sara Ali Abd El-Latif- Alaa Emad El Din – Eisha Youssef Applications of acetone Hagar Saeed – Shrouk Abd El-Aziz – Mona Ashraf Ramadan – Nahed Atia –Mai Mahmoud-Haidy Mahmoud – Walaa Ebada Uses of Anisole Khaled Eid- Sameh Raafat- Bishoy Shanoda- Sobhy Sabry-Ahmad Saeed Shehata-Abd El Rahman Abd El Aziz-Ahmad Zian-Mohamad Waheed Applications of Salicylic acid in industry Aya Ibrahim – Shreen Hassan – Mohamad Ahmad Torky- Mohamad Montaser- Doaa Sabri-Asmaa Gamal-Mahmoud Ezzat-Shady – Rewan Mohamad-Ahmad-Taha Mohamad Nasri - Eisha Ali Effect of Formaldehyde on health

31. Assignments(3) Group A and Group B Hend Nazmy – Heba Waheed – Hagar Eman Gamal - Adel Intermolecular Hydrogen bond Mostafa Ahmad Shata – Abd El Rahman Ali- Mohamad Magdi- Motasem Abd El-Aal Acidity of Alcohols Mohamad Mahmoud Awad-Marwa Ahmad- Sara Emad –Mariam Hamdy Applications of Benzoic acid Marina Maged-Nourhan Emad-Engy Roshdy- Madonna Micheal-JosianIsaq-Merna Farag Allah-Christin Magdi-Verona Romani- Makarious Maher-Mena Malak Organic compounds in food

32. Assignments(4) Group A and Group B Eman Gamal- Mona Ashraf Kamal- Fahd Abd El Salam-Mohamad Montaser-Wasal Mohamad Effect of Phenol on health Kholod El-Said – Riham Hassan – Esraa Hafez-Asmaa Basha –Asmaa Mohamad Hassan-Dina Nassem Cancer Ibrahim Abd El Aatti-John Micheal-Bishoy Sadeek Uses of Toluene Mariam Thrwat- Kyrillos Rafaat – Mina Kabeel-Fadi Abd El Salam InfraRed spectroscopy

33. Recommended textbooks: 1-Raymond Chang. Chemistry: An introduction to organic chemistry. 10th ed. 2009 2008 2-Zumdehl. Organic Chemistry; study guide and solution manual. 2008