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Grignard Reaction Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium Key features: Strong base such as.

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Presentation on theme: "Grignard Reaction Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium Key features: Strong base such as."— Presentation transcript:

1 Grignard Reaction Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. n-Butyl lithium Key features: Strong base such as KO t Bu, NaH, n-BuLi handled. Boron trifluoride etherate Key features: Moisture sensitive catalyst BF 3 :Et 2 O handled. Reaction Handled

2 Key features: Handling of air/ moisture sensitive chemicals, formation of C-C bond. Suzuki Coupling Key features: Handling of air sensitive reagents, Aromatic C-C bond formation. Negishi Coupling Gomberg Reaction Key features: Handling of diazonium salt. Aromatic C-C bond formation. Reaction Handled

3 Ritter Reaction Key features: Displacement of tertiary alcohol group with amido group. Vilsmeier-Haack Reaction Key features: POCl 3 handling. Typical formylation reaction. Kolbe Carboxylation Key features: Handling of high pressure reaction. Reaction Handled

4 Birch Reduction Key features: Handling of pyrophoric metals. Aromatic reduction. Baeyer-Villiger Oxidation Key features: Handling of reactive chemical, like peracid, Peroxide, etc. Borane Reduction Key features: Pyrophoric BDMS handled. Reaction Handled

5 Hofmann Rearrangement Key features: Hypobromite handled. Synthesis of amine from ketone. Reformatsky Reaction Key features: Handling of sensitive organometallic reagent Skraup Synthesis Key features: Oxidation using H 2 SO 4 and Nitrobenzene. Reaction Handled

6 Chiral Separation Key features: Separation of racemic pure compound. Asymmetric Hydrogenation Key features: Synthesis of optically pure compound. Asymmetric Reduction Key features: Handeled pyrophoric reagents. High ee achieved. Reaction Handled

7 Transesterification Key features: Acid/ base catalyzed transesterification. Click Chemistry Key features: One-pot triazole chemistry. Thiophene Chemistry Key features: Handeled n-BuLi, sulfur dioxide gas. Reaction Handled


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