1. Absorption enhancements
How they work

2. Dermoelectroporation® provides..
Dermoelectroporation Technology provides the following:
Skin Bio Revitalization treatments

3. Existing Technologies
Microdermabrasion
Medical and Aesthetic application
1st transdermal pathway
Small molecules allowed to pass
Low delivery rate (twice topical)
Effects limited to the skin surface
No current applied
For use on human beings

4. Existing Technologies
Traditional Pulsed Ionthophoresis (1to 5mA)
Medical and Aesthetic application
Only small molecules allowed
Ineffective for high weight molecules
Low AC current level applied
Changes the pH of ionic drug solutions
Electrolysis of the ionic solution
For use on human beings
Low AC current level applied

5. Existing Technologies
Traditional Galvanic Ionthophoresis (1to 5mA)
Medical and Aesthetic application
Only small molecules allowed
No high weight molecules delivered
Low DC current level applied
Changes the pH of ionic drug solutions
Electrolysis of the ionic solution
For use on human beings
Low DC current level applied

6. Existing Technologies
Electroporation (higher than 5mA)
In vitro application only
High peak currents to “porate”
the stratum corneum
High risk of skin damage
Big sized molecules deliverable
Adverse effects
For in lab test only not to use on
human beings
High peak current level applied

7. Existing Technologies
Aquaphoresys (1to 5mA)
Medical and Aesthetic application
Only small molecules allowed
Ineffective for high weight molecules
Ultrasounds and current applied
Changes the pH of ionic drug solutions
Electrolysis of the ionic solution
For use on human beings
Low AC current level applied

8. Existing Technologies
Ultrasounds
Medical and Aesthetic application
No current applied
High vibration frequency on the skin
Infra-cellular spaces involved
Small molecules allowed to pass
Low delivery rate (twice topical)
Effects limited to the skin surface
For use on human beings

9. Existing Technologies
Sonphoresys
Medical and Aesthetic application
No current applied
Sonic waveforms the skin
Infra-cellular spaces involved
Small molecules allowed to pass
Low delivery rate (twice topical)
Effects limited to the skin surface
For use on human beings

10. Existing Technologies
Micro-currents (0 to .5mA)
Aesthetic application only
Very small current applied
Very Low delivery rate
Effects limited to the skin surface
For use on human subjects

11. Existing Technologies
Cosmetic absorption enhancers (.5 to 1mA)
Aesthetic application only
Very small current applied
Low/mid delivery rate
Effects limited to the skin surface
Infra-cellular spaces involved
Small molecules allowed to pass
For use on human beings

12. Existing Technologies
Topical Patches
Local Aesthetic application only
Very low current applied
Very Low delivery rate (takes more time)
Effects limited to the skin surface
Some adverse effect reported
For use on human beings

13. Innovation in transdermal “drug” Delivery
Why we say Innovation?
3 big problems not solved yet with old technologies:
1) Transdermal delivery of macromolecules without side effects
2) Irritation associated to long treatments sessions
3) Efficacy in the long term
Engineering of Florence - Italy developed a new methodology
using the new Dermoelectroporation technology part of the
Transdermal Delivery procedure that eliminates those problems.

14. Dermoelectroporation® Solution
Dermoelectroporation® removes the limitations…
combines the advantages of the existing technologies
to create the COLLAGENIZER® system

15. Latest innovation in transdermal Collagen delivery
How we solve problems ?
1) Transdermal delivery of macromolecules without side effects
Collagenizer® can deliver either micro and macro molecules using low current as proven by scientific publications, clinical reports, studies and doctors using the machine worldwide.
2) Irritation associated to long treatments session Collagenizer® can deliver any type of drugs with no additional return electrode to avoid discomforts
3) Efficacy in the long term Collagenizer® is used by professional users getting astonishing results instantly, mid and long term.

16. Dermoelectroporation® means…
Dermo = From preventive MicroDERMoabrasion.
Electroporation = From the shape of the electrical pulses that are instead lowered in current - max 1mA- delivered on the dermis after microdermabrasion. These pulses that are similar in shape to the electroporation, are instead, completely different from those in value, time duration, electrical characteristics.

17. Dermoelectroporation® features
Dermoelectroporation technology ……
utilizes the skin’s water based “channels”
Controlled “electroporation-like” continuous reversed polarity electrical pulses (Average current value on the patient is zero).
Increase the skin permeability to allow transdermal delivery of micro-molecules and macro-molecules
No modification of the ionic drug solutions pH and no electrolysis effect of the ionic solution itself.
 Dermoelectroporation takes less time vs traditional Ionthophoresis devices to deliver the same amount of ionic drug solution.
Dermoelectroporation does not need any skin pH-Compensating patch because does not causes irritation on the skin as Ionthophoresis devices do.

18. Dermoelectroporation® …
Unique features:
Allow to deliver macromolecules (greater than d)
Positive and negative ions of the drug are delivered at the same time
Do not cause Electrolysis neither change the drug pH
Do not irritate nor make any damage to the skin.
Do not need return electrode, conductive gels, pre charged compounds, pH compensating patches.
Allow to determine the dosage to administer.
Allow the reproducibility of the treatment.

19. Dermoelectroporation® closeup…
Skin
Water based channels
Molecules ions

20. More effective than traditional systems
Results of Dermoelectroporation®
Transdermal delivery of:
Ionic solution of low-weight molecules
More effective than traditional systems
Transdermal delivery feature not available for patients with other techniques

21. Advantages of Dermoelectroporation®

22. Courtesy of Dr. Jaggy Rao, MD University of Edmonton ,Alberta,Canada
Before!

23. After!
Courtesy of Dr. Jaggy Rao, MD University of Edmonton ,Alberta,Canada