1. Connecting South Carolina: The Gibbs/Hollings Cancer Center An NCCCP/NCI Designated Center Connection Anita L. Harrison, MPH Associate Director, Administration Hollings Cancer Center

2. History in the Making Good working, informal relationship for greater then a decade Relationship was greatly strengthened in 2004 with the partnership to establish a Center of Excellence in GI Malignancies Further formalized in 2005 as Gibbs Cancer Center at Spartanburg Regional Health System joined the Hollings Cancer Center Clinical Trials Network A Memorandum of Understanding executed in 2009 to outline a roadmap of future joint initiatives

3. Joint Initiatives In progress: Joint Biospecimen Repository – Working with Gibbs to launch biospecimen collection efforts, utilizing a common IT system, TissueMetrix START- “Survivor Taking Action in Recovery Today” R21- Optimizing Survivorship and Surveillance after Treatment for Colon Cancer R01- Patient Navigation to Improve the Surgical Resection Rate among African Americans with Early Stage, Non-Small Cell Lung Cancer (NSCLC) in South Carolina

4. Everyone involved needs to understand both the community/private practice and the academic perspectives/approaches and find common paths to win:win situations Institutional leadership has to be supportive (beyond Cancer Center) Designated point people at both institutions to ensure “next steps” is key Overcome geographical barriers Lessons Learned

5. NavIGATE Navigation to Increase Guidance and Awareness of Trials for Thoracic and Esophageal Cancers A NCI Cancer Center Supplemental Grant (CCSG) to support collaborative pilot projects with NCI Community Cancer Centers Program (NCCCP) Sites

6. Background Less than 2.5% or 21 patients of the 835 new lung and esophageal cases seen at the three partner sites in 2008 enrolled to a therapeutic clinical trial Of those who enrolled, only 1 was African American

7. Project Objectives Examine if the integration of a lay navigator can improve the rate of therapeutic enrollment and protocol compliance Further understand factors contributing to the lack of enrollments, particularly among underserved and minority patients Lay Navigator PhysiciansNurses Study Coordinators

8. Project Launch Lay navigators who were part of the minority community were identified in each of 3 centers Trial portfolio was synchronized among all 3 sites and continues to be monitored Lay navigators completed comprehensive didactic training and shadowing experience

9. Cultural Competency Training Study personnel from all 3 sites participated in cultural competency standardized patient training (6 modules were developed as part of project)

10. Project Overview Pre & Post intervention surveys collected Lay navigator contributions: –Identify patient needs and connect patients to available resources –Provide education and patient reminders to enhance adherence to trial treatment plan –Serve as patient advocate and facilitate communication with treatment care team Pt. eligible for Therapeutic Clinical Trial Pt. asked to participate in NavIGATE If yes, pt. meets navigator Healthcare team discuss treatment options including clinical trial, (navigator included) Navigator meets with patient and shows NCI clinical trials video Patient communicates the treatment regimen decision

11. Preliminary Results 24 patients have been eligible and consented to the NavIGATE trial 17 patients consented to a therapeutic clinical trial 11 patients were eligible to enroll in a therapeutic clinical trial 4 African Americans have enrolled in a therapeutic clinical trial

12. Lay Navigator Barrier Plans 40 lay navigator barrier plans documenting patient interventions for 16 participants Intervention categories included: –Communication with medical personnel –Insurance and/or financial concerns –Transportation issues –Perceptions and beliefs about treatment –Attitudes toward providers –Fear and emotional issues –Literacy “Learned that patient was taking study medication incorrectly…relayed information to the physician and nurse” “Arranged transportation so patient could make clinic appointments” “Patient dealing with poor nutrition and performance status… worked with nurse and helped refer patient to nutritionist in aims to keep patient on trial”