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Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)

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Presentation on theme: "Gaucher Disease: Bone Imaging. DXA (Dual-Energy X-ray Absorptiometry)"— Presentation transcript:

1 Gaucher Disease: Bone Imaging

2 DXA (Dual-Energy X-ray Absorptiometry)

3 DXA Spine Image and Test Results

4 DXA Hip Image and Test Results

5 Absorptiometry

6 BMD ↓ DXA: Trabecular Bone Change

7 BMD ↓ DXA: Cortical Bone Change

8 Computed Tomography

9 Whole-body CT Scan With Vertebra

10 Close-up of Vertebra

11 Forearm CT Scan

12 Image of Radius and Ulna

13 TBD ↓ TBD ↔ Quantitative Computed Tomography (QCT): Trabecular Bone Change

14 CBD ↓ CBD ↔ QCT: Cortical Bone Change

15 Possible Conditions for Bone Loss Resorption ↑ Formation ↔ Resorption ↔ Formation ↓ Resorption ↑ Formation ↓ Negative Balance

16 Follow-up Measurements 123 Measurement 0.5 0.6 0.7 0.8 BMD [g/cm 2 ]

17 Significant Differences 12 Measurement Point 0.60 0.65 0.70 0.75 0.80 0.85 BMD [g/cm 2 ]  2.8 sd (p>95%) sd 


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