VENTILATOR THE BASIC- COURSE.

VENTILATOR THE BASIC- COURSE

HISTORY OF VENTILATOR

Early History of Ancient times
Old testament there is a mention of Prophet Elisha Inducing pressure breathing from his mouth into the mouth of a child who was dying–(Kings 4:34-35). Hippocrates ( BC) wrote the first description of endotracheal intubation his book –‘Treatise on Air’ “One should introduce a cannula into the trachea along the jaw bone so that air can be drawn into the lungs”.

Negative Pressure Ventilators
Two successful designs became popular; In one - the body of the patient was enclosed in an iron box or cylinder and the patient’s head protruded out of the end. The second - design was a box or shell that fitted over the thoracic area only (chest cuirass).

IRON LUNG- DRINKER LUNG
(Philip Drinker and Louis Agassiz Shaw) mid-1900s The first iron lung was used on October 12, 1928 at Children's Hospital, Boston, -used in a child unconscious from respiratory failure; -her dramatic recovery, within seconds popularize the "Drinker Respirator."

In 1949, John Haven Emerson Developed a mechanical assister for anesthesia at Harvard University.

Iron lung ward filled with Polio patients,
Rancho Los Amigos Hospital, ca. 1953

Woman lying in negative pressure ventilator (iron lung).

During the 1950's Mechanical ventilators used increasingly in Anesthesia and intensive care. -To treat polio patients and -The increasing use of muscle relaxants during anesthesia

MODERN VENTILATOR

THE COURSE DEALS WITH INTRODUCTION
INDICATION FOR MECHANICAL VENTILATION MECHANICAL VENTILATOR- WHAT IT IS ? MECHANICAL VENTILATORS- CLASSIFICATION VENTILATOR MODES HOW TO INITIATE MECHANICAL VENTILATION? VENTILATOR SETTINGS NURSING CARE SEDATION AND NEUROMUSCULAR BLOCKADE ASSESMENT CRITERIA WEANING AND EXTUBATION FAILURE TO WEAN METHODS OF WEANING POST EXTUBATION CARE

P0ST-TEST EVALUATION HANDS ON VENTILATOR HANDS ON INTUBATING MANNIQUINE

WHAT A MOST IMPORTANT THING A DOCTOR SHOULD KNOW
AFTER THIS COURSE ? MONITORING THE PROGRESS

WHAT A MOST IMPORTANT THING A ICU STAFF SHOULD KNOW
AFTER THIS COURSE ? ALARMS AND CARE OF THE PATIENT

VENTILATOR THE BASIC

Mechanical ventilation is used when. a patient is unable to breathe
Mechanical ventilation is used when a patient is unable to breathe adequately on his or her own. The ventilator can either completely take over respiratory function, or it can be used to support the patient’s own respiratory efforts

MECHANISM OF RESPIRATION
A mechanism for telling the body that it is time to breath: This involves CO2 sensors in the brainstem, which signal diaphragmatic movement via the cervical nerves. The phrenic nerves The diaphragm contracts – it increases the volume of the thorax, by moving down into the abdomen, making the intra-pleural and intra-alveolar pressure more negative, creating a pressure gradient between the atmospheric and the alveoli, and allowing air to pass down through a series of narrowing bronchi into the alveoli. The alveoli and the pulmonary capillary network, Derived from the main pulmonary arteries, oxygen and carbon dioxide diffuse across the concentration gradient out of and into the alveoli respectively. The diffusion of CO2 is more effective due to it’s higher solubility.

Indications for mechanical ventilation:
Ventilation Failure Oxygenation Failure

Failure to Ventilate Characterized by reduced alveolar ventilation
which manifests as an increase in the PaCO2 > 50 mmHg

Indications for mechanical ventilation:
Is it failure to ventilate (is the PCO2 > 50mmHg), or failure to oxygenate (is the PO2 <50mmHg)? Remember that a low O2 is much more significant than a high PCO2, If it is ventilatory failure, where is the injury – in the brain (the medulla), in the spinal cord, in the peripheral nerves, at the neuromuscular junction, in the muscle itself or in the chest cage? If the problem is oxygenation failure, where is the injury: Is it in the blood supply, at the alveolar-capillary interface or in the upper, middle or lower airways?

Neurological Problems ( Ventilatory failure )
Central: Loss of ventilatory drive due to sedation, narcosis, stroke or brain injury. Spinal: Spinal cord injury, cervical – loss of diaphragmatic function, thoracic – loss of intercostals. Peripheral: Nerve injury (e.g. phrenic nerve in surgery), Guillain-Barre syndrome (demyelination), poliomyelitis, motor neurone disease. Muscular Problems – myasthenia gravis, steroid induced myopathy, protein malnutrition. Anatomical Problems Chest Wall – rib fractures or flail chest, obesity, abdominal hypertension, restrictive dressings Pleura – pleural effusions, pneumothorax, hemothorax. Airways – airway obstruction (in lumen, in wall, outside wall), laryngeal edema, inhalation of a foreign object, bronchospasm

Alveoli are ventilated but not perfused
Failure to Oxygenate Diffusion abnormality – Thickening of the alveoli (fibrosis) Increased extracellular fluid – pulmonary edema. This obstructs gas exchange. Ventilation/Perfusion Mismatch : Dead Space Ventilation (or high V/Q)– Alveoli are ventilated but not perfused Eg; pulmonary embolus Dead space may be anatomical - the conducting airways(150ml) physiological, for example in hemorrhage or hypotension Shunt (or low V/Q)– where alveoli are perfused but not ventilated occurs in airway collapse, pneumonia, pulmonary hemorrhage (contusion), ARDS/ALI. Inability to extract O2 at cellular level – sepsis, cyanide or carbon monoxide poisoning

Mechanical Ventilator
What is it?

Mechanical Ventilator What is it?
A mechanical ventilator is a machine that generates a controlled flow of gas into a patient’s airways Two kinds of ventilators: Negative pressure and Positive pressure. Negative Pressure : -iron lung, the Drinker respirator, and the chest shell -advantage these ventilators didn’t require insertion of an artificial airway, -disadvantage they were noisy and made nursing care difficult. Positive Pressure : -The Emerson Company in Boston developed the positive pressure ventilator, which was first used at Massachusetts General Hospital.

Positive pressure ventilators
Require an artificial airway (endotracheal or tracheostomy tube), and use positive pressure to force oxygen into a patient’s lungs Inspiration can be triggered either by the patient or the machine. Four types of positive pressure ventilators: volume cycled pressure cycled -deliver a preset tidal volume -ideal for patients with bronchospasm since the same tidal volume is delivered regardless of the amount of airway resistance -deliver gases at preset pressure -decreased risk of lung damage from high inspiratory pressures -disadvantage is that the patient may not receive the complete tidal volume if he or she has poor lung compliance and increased airway resistance

-deliver a breath until a preset flow rate
flow cycled time cycled -deliver a breath until a preset flow rate These aren’t used -deliver a breath over a preset time period expiration is passive . gas flows along a pressure gradient between the upper airway and the alveoli Flow is either volume targeted and pressure variable, or pressure limited and volume variable. The pattern of flow may be either sinusoidal (which is normal), decelerating or constant. Flow is controlled by an array of sensors and microprocessors.

Mechanical Ventilators
Classification

Mechanical Ventilators Classification
1) Control Either Volume Controlled (volume limited, volume targeted) and Pressure Variable or Pressure Controlled (pressure limited, pressure targeted) and Volume Variable or Dual Controlled (volume targeted (guaranteed) pressure limited) 2) Cycling: Time cycled - such in in pressure controlled ventilation Flow cycled - such as in pressure support Volume cycled - the ventilator cycles to expiration once a set tidal volume has been delivered: this occurs in volume controlled ventilation -If an inspiratory pause is added, then the breath is both volume and time cycled (contd)

what causes the ventilator to cycle to inspiration?
3) Triggering: what causes the ventilator to cycle to inspiration? Ventilators may be time triggered, pressure triggered or flow triggered. Time: the ventilator cycles at a set frequency as determined by the controlled rate. Pressure: the ventilator senses the patient's inspiratory effort by way of a decrease in the baseline pressure. Flow: modern ventilators deliver a constant flow around the circuit throughout the respiratory cycle (flow-by). A deflection in this flow by patient inspiration, is monitored by the ventilator and it delivers a breath. This mechanism requires less work by the patient than pressure triggering. (Contd)

what causes the ventilator to cycle from inspiration?
4) Breaths are either: what causes the ventilator to cycle from inspiration? Mandatory (controlled) - which is determined by the respiratory rate. Assisted - (as in assist control, synchronized intermittent mandatory ventilation, pressure support) Spontaneous- (no additional assistance in inspiration, as in CPAP) 5) Flow pattern: constant, accelerating, decelerating or sinusoidal Sinusoidal = this is the flow pattern seen in spontaneous breathing and CPAP Decelerating = the flow pattern seen in pressure targeted ventilation: inspiration slows down as alveolar pressure increases (there is a high initial flow). (Contd)

Constant - flow continues at a constant rate until the set tidal volume is delivered
Accelerating - flow increases progressively as the breath is delivered. This should not be used in clinical practice Flow Pattern

KEY-POINTS 1. The resting point of outward chest spring and inward lung collapse is the Functional Residual Capacity (FRC): this is a reservoir for gas exchange .The FRC is the lung’s physiologic reserve, it is a reservoir. 2. Loss of chest wall or lung compliance causes reduced FRC. 3. Exhalation below FRC is active causing dynamic airway collapse, trapping air in the alveoli (auto PEEP) 4. At residual volume it is not possible to empty alveoli of air further, due to dynamic airway collapse (airway closure) 5. The closing volume (CV) is the point at which dynamic compression of the airways begins. 6. Such airway closure occurs normally within FRC, and it is known as the closing volume (CV). With age and disease the CV moves into the tidal breathing range. 7. The CV increases with age, smoking, lung disease, and body position (supine > erect). 8. Airway collapse increases the work of breathing and leads to ventilation-perfusion mismatch 9. In mechanically ventilated patients airway collapse is prevented by applying positive pressure to the airway throughout the respiratory cycle – CPAP/PEEP 10. PEEP/CPAP works by increasing FRC, maintaining alveolar recruitment facilitating gas exchange (and removal of CO2 and replenishment of O2), and reducing the workload of breathing. 11. The patient requires sufficient PEEP to prevent alveolar de-recruitment, but not so much PEEP that alveolar over-distension, dead space ventilation and hypotension occurs. 12. The ideal level of PEEP is that which prevents de-recruitment of the majority of alveoli, while causing minimal over-distension. 13. Recruitment maneuvers are used to re-inflate collapsed alveoli, a sustained pressure above the tidal ventilation range is applied, and PEEP is used to prevent de-recruitment. 14. Auto-PEEP is gas trapped in alveoli at end expiration, due to inadequate time for expiration, bronchoconstriction or mucus plugging. It increased the work of breathing. 15. The increased work of breathing associated with auto-PEEP can be offloaded by applying CPAP to the trachea/mouth, and splinting open the connecting airways. The objective is to set the CPAP level above the auto-PEEP level.

VENTILATOR WAVE FORMS

Ventilator Waveforms Airway pressure screen Step 1: - determine the CPAP level – this is the baseline position from which there is a downward deflection on, at least, beginning of inspiration, and to which the airway pressure returns at the end of expiration. Step 2: is the patient triggering? -There will be a negative deflection into the CPAP line just before inspiration

Step 3: what is the shape of the pressure wave?
-If the curve has a flat top, then the breath is pressure limited, if it has a triangular or shark’s fin top, then it is not pressure limited and is a volume breath. Flow screen: Step 4: what is the flow pattern? – If it is constant flow (square shaped) this must be volume controlled, if decelerating, it can be any mode.

Is the patient gas trapping? –
expiratory flow does not return to baseline before inspiration commences (i.e. gas is trapped in the airways at end-expiration). Step 4: the patient is triggering – is this a pressure supported or SIMV or VAC breath? -This is easy, the pressure supported breath looks completely differently than the volume control or synchronized breath: the PS breath has a decelerating flow pattern, and has a flat topped airway pressure wave. The synchronized breath has a triangular shaped pressure wave. Airway pressure Flow pattern

Step 5: the patient is triggering – is this pressure support or pressure control?
-The fundamental difference between pressure support and pressure control is the length of the breath – in PC, the ventilator determined this (the inspired time) and all breaths have an equal “i” time. In PS, the patient determined the duration of inspiration, and this varies from breath to breath.

Step 6: is the patient synchronizing with the ventilator?
-Each time the ventilator is triggered a breath should be delivered. If the number of triggering episodes is greater than the number of breaths, the patient is asynchronous with the ventilator. Further, if the peak flow rate of the ventilator is inadequate, then the inspiratory flow will be "scooped" inwards, and the patient appears to be fighting the ventilator. Both of these problems are illustrated below

Ventilator Modes

Ventilator Modes Control Ventilation (CV)
Assist-Control Ventilation (A/C) Synchronous Intermittent Mandatory Ventilation (SIMV) Pressure Support Ventilation (PSV) Positive End Expiratory Pressure (PEEP) Constant Positive Airway Pressure (CPAP) Independent Lung Ventilation (ILV) High Frequency Ventilation (HFV) Inverse Ratio Ventilation (IRV) Advanced Pressure Control Modes -Inverse Ratio Ventilation (IRV) and Airway Pressure Release Ventilation (ARPV), -Bilevel and Proportional Assist Ventilation?

1)Control Ventilation (CV)
-CV delivers the preset volume or pressure regardless of the patient’s own inspiratory efforts. -This mode is used for patients who are unable to initiate a breath. -If it is used with spontaneously breathing patients, they must be sedated and/or pharmacologically paralyzed so they don’t breathe out of synchrony with the ventilator.

2)Assist-Control Ventilation (A/C)
-A/C delivers the preset volume or pressure in response to the patient’s own inspiratory effort but will initiate the breath if the patient does not do so within the set amount of time. -This means that any inspiratory attempt by the patient triggers a ventilator breath. -The patient may need to be sedated to limit the number of spontaneous breaths since hyperventilation can occur. -This mode is used for patients who can inititate a breath but who have weakened respiratory muscles.

3) Synchronous Intermittent Mandatory Ventilation (SIMV)
-SIMV was developed as a result of the problem of high respiratory rates associated with A/C. -SIMV delivers the preset volume or pressure and rate while allowing the patient to breathe spontaneously in between ventilator breaths. -Each ventilator breath is delivered in synchrony with the patient’s breaths, yet the patient is allowed to completely control the spontaneous breaths. -SIMV is used as a primary mode of ventilation, as well as a weaning mode. -The disadvantage of this mode is that it may increase the work of breathing and respiratory muscle fatigue.

4) Pressure Support Ventilation (PSV)
-PSV is preset pressure that augments the patient’s spontaneous inspiratory effort and decreases the work of breathing. -The patient completely controls the respiratory rate and tidal volume. -PSV is used for patients with a stable respiratory status and is often used with SIMV to overcome the resistance of breathing through ventilator circuits and tubing.

5) Positive End Expiratory Pressure (PEEP):
-PEEP is positive pressure that is applied by the ventilator at the end of expiration. -Used as an adjunct to CV, A/C, and SIMV to improve oxygenation by collapsed alveoli at the end of expiration. -Complications decreased cardiac output, pneumothorax, and increased intracranial pressure.

6) Constant Positive Airway Pressure (CPAP)
-CPAP is similar to PEEP except that it works only for patients who are breathing spontaneously. -The effect of both is comparable to inflating a balloon and not letting it completely deflate before inflating it again. The second inflation is easier to perform because resistance is decreased. -CPAP can also be administered using a mask.

7) Independent Lung Ventilation (ILV)
-This method is used to ventilate each lung separately in patients with unilateral lung disease or with a different disease process in each lung. -It requires a double-lumen endotracheal tube and two ventilators. -Sedation and pharmacological paralysis are used to facilitate optimal ventilation and increased comfort for the patient. 8) High Frequency Ventilation (HFV) -HFV delivers a small amount of gas at a rapid rate (as much as breaths per minute.) -This is used when conventional mechanical ventilation would compromise hemodynamic stability, during short-term procedures, or for patients who are at high risk for pneumothorax. -Sedation and pharmacological paralysis are required.

9) Inverse Ratio Ventilation (IRV)
-The normal inspiratory:expiratory ratio is 1:2 but this is reversed during IRV to 2:1 or greater (the maximum is 4:1). -This mode is used for patients who are still hypoxic even with the use of PEEP. -The longer inspiratory time increases the amount of air in the lungs at the end of expiration (the functional residual capacity) and improves oxygenation by reexpanding collapsed alveoli. -The shorter expiratory time prevents the alveoli from collapsing again. -Sedation and pharmacological paralysis are required since it’s very uncomfortable for the patient.

MODE FUNCTION CLINICAL USE
Control Ventilation (CV) Delivers preset volume or pressure Usually used for patients who are apneic regardless of patient’s own inspiratory efforts Assist-Control Ventilation (A/C) Delivers breath in response to Usually used for spontaneously patient effort and if patient fails to breathing patients with weakened do so within preset amount of time respiratory muscles Synchronous Intermittent Mandatory Ventilator breaths are synchronized Usually used to wean patients from mechanical ventilation with patient’s respiratory effort Ventilation (SIMV) Pressure Support Ventilation (PSV) Preset pressure that augments the Often used with SIMV during weaning patient’s inspiratory effort and decreases the work of breathing Positive End Expiratory Pressure (PEEP) Positive pressure applied at the end Used with CV, A/C, and SIMV to Improve oxygenation by opening collapsed alveoli of expiration Constant Positive Airway Pressure Similar to PEEP but used only with Maintains constant positive pressure in airways so resistance is decreased spontaneously breathing patients (CPAP)

MODE FUNCTION CLINICAL USE
Independent Lung Ventilation (ILV) Ventilates each lung separately; Used for patients with unilateral lung disease or different disease process In each lung requires two ventilators and sedation/paralysis High Frequency Ventilation (HFV) Delivers small amounts of gas at a Used for hemodynamic instability, during short-term procedures, or if patient is at risk for pneumothorax rapid rate ( breaths/minute); requires sedation/paralysis Inverse Ratio Ventilation (IRV) I:E ratio is reversed to allow longer Improves oxygenation in patients who are still hypoxic even with PEEP; keeps alveoli from collapsing inspiration; requires sedation/ paralysis

Volume Control Ventilation
Anesthesiologists use mechanical ventilators in the operating room. These are “bag in bottle” mechanical bellows which are controlled by three factors: 1) tidal volume, 2) respiratory rate, 3) I:E ratio. Conventional anesthesia ventilator: the patient is delivered mandatory breaths from a “bag in bottle” ventilator. He can also draw unsupported spontaneous breaths from an in-line reservoir bag:

-Longer inspiratory times and faster respiratory rates predispose to alveolar gas trapping
Pressure-assist ventilation – Pressure assist ventilation is pressure control without a set rate. Patients take pressure controlled breaths at the rate of their choosing, and the volumes derived are determined by the pressure preset level, the Ti and the flow demanded. This is a very comfortable mode, and is used in weaning from pressure control (the pressure limit is weaned).

Pressure Controlled Ventilation
controlled (CMV) pressure control. assist-controlled SIMV “The term “pressure control” refers to an assist control mode” -A pressure limited breath is delivered at a set rate. -The tidal volume is determined by the preset pressure limit. -The flow waveform is always decelerating in pressure control -Gas flows into the chest along the pressure gradient. -As the airway pressure rises with increasing alveolar volume the rate of flow drops off (as the pressure gradient narrows) until a point is reached. when the delivered pressure equals the airway pressure: flow stops. -The pressure is maintained for the duration of inspiration . Obviously, longer inspiratory times lead to higher mean airway pressures (the “i” time (Ti) is a pressure holding time after flow has stopped). -The combination of decelerating flow and maintenance of airway pressure over time means that stiff, noncompliant lung units (long time con which are difficult to aerate are more likely to be inflated. -Drawbacks of pressure control? -Pressure control does not guarantee minute ventilation. change in the compliance, then the patient may hypoventilate and become hypoxic.

Volume Assist Control In volume assist-control -often labelled “volume control” -patients may receive either controlled or assisted breaths. -When the patient triggers the ventilator, he/she receives a breath . -The patient receives a breath of this type irrespective of actual minute ventilation requirement, so patients tend to hyperventilate as they emerge. Assist control (AC) ventilation involves the use of four variables: -tidal volume -respiratory rate - inspiratory flow (as an alternative to I:E ratio) -trigger sensitivity If the flow rate is too high, the volume is rapidly delivered to only the most compliant lung tissues (and not to the inelastic diseased tissues), If the peak flow is too low, the patient will demand more gas than the ventilator is set up to supply and dysynchrony with the machine occurs

tidal volume is identical
The inspiratory flow rate is measured in liters per minute, and it determines how quickly the breath is delivered. The time required to complete inspiration is determined by the tidal volume delivered and the flow rate: Ti = VT/Flow Rate. controlled breaths assisted breaths decelerating flow pattern tidal volume is identical

Ventilation How to Initiate Mechanical Ventilation

Ventilation How to Initiate Mechanical Ventilation
The ventilation strategy -is determined by whether the patient has failure to ventilate or failure to oxygenate. -The first problem is managed by increasing the patients minute ventilation, -the second by recruiting collapsed lung units and controlling mean airway pressure. Sedation- fentanyl or morphine with lorazepam, midazolam or propofol For profoundly hypoxemic patients, the addition of a neuromuscular blocking agent

The Procedure of Rapid Sequence Induction Preparation:
Drugs: thio/ propofol/ etomidate/ midazolam, succinyl choline, atropine, ephedrine/phenylephrine. Endotracheal tubes: a variety of sizes available and cuff checked (to make sure that the cuff is intact -–ie. Not punctures) Laryngoscopes – 2 functioning laryngoscopes with a variety of blades. Suction – on and under the pillow. A Gum elastic bougie – to railroad the ETT if there is difficulty in placing the ett. An intravenous cannula, with a free-flowing drip Monitoring: blood pressure, ECG, pulse oximetry, end tidal CO2 (if available).

Options: 1. Awake intubation +/- local anesthesia applied topically.
2. Sedation with midazolam +/- local anesthetic. 3. Midazolam + succinylcholine 4. Ketamine + succinylcholine (small babies). 5. Thiopental or propofol + succinylcholine 6. Etomidate + succinylcholine

Ventilator Settings

Ventilator Settings Respiratory Rate (RR)
-The respiratory rate is the number of breaths the ventilator delivers to the patient each minute. -The rate chosen depends on the tidal volume the type of pulmonary pathology the patient’s target PaCO2. -Obstructive lung disease, the rate should be set at 6-8 breaths/minute to avoid the development of auto-PEEP and hyperventilation -Restrictive lung disease usually tolerate a range of breaths/minute. - Patients with normal pulmonary mechanics can tolerate a rate of breaths/minute. Tidal Volume (VT) -The tidal volume is the volume of gas the ventilator delivers to the patient with each breath. -The usual setting is 5-15 cc/kg, based on compliance, resistance, and type of pathology. -Patients with normal lungs can tolerate a tidal volume of cc/kg, -Patients with restrictive lung disease may need a tidal volume of 5-8 cc/kg.

To start a patient on assist-control one must select
-a PEEP (as determined by lung compliance), -a minute volume (MV 100ml/kg), -a tidal volume (TV 6ml/kg), and a peak flow. -The respiratory rate is the MV/TV. -The peak flow is usually four times the minute ventilation. -The trigger is either set as “flow-by” or a negative pressure of -2cmH2O

Fractional Inspired Oxygen (FIO2)
-The fractional inspired oxygen is the amount of oxygen delivered to the patient. It can range from 21% (room air) to 100%. -Oxygen toxicity causes structural changes at the alveolar-capillary membrane, pulmonary edema, atelectasis, and decreased PaO2. Inspiratory:Expiratory (I:E) Ratio -The I:E ratio is usually set at 1:2 or 1:1.5 Pressure Limit -The pressure limit regulates the amount of pressure the volume-cycled ventilator can generate to deliver the preset tidal volume. -High pressures can cause lung injury, it’s recommended that the plateau pressure not exceed 35 cm H20. -Caused by airway is obstructed with mucus,the patient coughing, biting on the ETT, breathing against the ventilator, or by a kink in the ventilator tubing.

Flow rate -The flow rate is the speed with which the tidal volume is delivered. The usual setting is liters per minute. Sensitivity/Trigger -The sensitivity determines the amount of effort required by the patient to initiate inspiration. It can be set to be triggered by pressure or flow Sigh -The ventilator can be programmed to deliver an occasional sigh with a larger tidal volume. it prevents collapse of the alveoli (atelectasis) Minute volume (VE) Minute volume is the total volume of air inhaled and exhaled in one minute. The patient’s minute volume should be less than 10 liters per minute.

Ventilator Settings The following is a summary of the settings that nurses deal with the most. SETTING FUNCTION USUAL PARAMETERS Respiratory Rate (RR) Number of breaths delivered usually 4-20 breaths/mt by the ventilator per minute Tidal Volume (VT) Volume of gas delivered during usually 5-15cc/kg each ventilator breath Fractional Inspired Amount of oxygen delivered by %-100% to keep Oxygen(FIO2) ventilator to patient PaO2>60mmHg or SaO2>90% Inspiratory:Expiratory Ratio Length of inspiration usually 1:2 or 1:1.5 (I:E) compared to length of expiration Pressure Limit Maximum amount of pressure cm H2O above the ventilator can use to PIP; maximum35cmH2O deliver breath

Alarms and Common Causes
High Pressure Low Pressure High Respiratory Rate Low Exhaled Volume Secretions in vent tubing not –patient anxiety or vent tubing not ETT/airway or connected pain connected condensation in displaced ETT secreations in ETT/ Leak in cuff or tubing or trach tube airway inadequate cuff seal • Kink in vent Hypoxia Tubing Hypercapnia Occurrence of • Patient biting on another alarm ETT preventing full • Patient coughing, delivery of breath gagging, or trying to talk • Increased airway pressure from bronchospasm or pneumothorax

Noninvasive Forms of Mechanical Ventilation

Noninvasive Forms of Mechanical Ventilation
Noninvasive positive pressure ventilation (NIPPV) include - patients who don’t have oxygenation problems, - who are able to manage their secretions, and - who don’t have an upper airway obstruction. CPAP Continuous Positive Airway Pressure (CPAP) CPAP can also be delivered through either a nasal mask or a full face mask. Full face masks - minimize air leaks, -more claustrophobic- must be removed for the patient to speak or expectorate secretions. - a smaller air leak leads to greater pressure buildup and gastric distention Nasal masks - less claustrophic and don’t have to be removed to speak or expectorate, - they usually have large air leaks BiPAP

Bi-level Positive Airway Pressure (Bi-PAP) similar to CPAP BiPAP maintains positive airway pressure during both inspiration and expiration The two levels are referred to as inspiratory positive airway pressure (IPAP) and expiratory positive airway pressure (EPAP) Benefits of IPAP increased tidal volume and minute ventilation, decreased PaCO2 level, relief of dyspnea, and reduced use of accessory muscles Benefits of EPAP increased functional residual capacity, resulting in an increased PaO2 level Bi-Pap is usually delivered through a nasal mask, allowing exhalation through the mouth

IPPB -Intermittent Positive Pressure Breathing (IPPB) is used after surgery or for a short time after mechanical ventilation has been discontinued. -The IPPB machine is a pressure-cycled ventilator that delivers compressed gas under positive pressure into the patient’s airway. -It’s triggered when the patient inhales,but it allows passive expiration. -Usually, breaths are given every 1-2 hours for 24 hours. -Benefits of IPPB include prevention of atelectasis, promotion of full-lung expansion, improved oxygenation, and administration of nebulized medications.

Nursing Care of the Mechanically Ventilated Patient

Nursing Care of the Mechanically Ventilated Patient
Nursing Care of the Endotracheal Tube (ETT) ETT management consists of - ensuring a patent airway, - suctioning pulmonary and oral secretions, and - providing frequent oral and/or nasal care. -secure ETT in place

Oral cavity should also be suctioned separately
-oral care should be provided every eight hours and as needed. Bite block -If the patient has a bite block to prevent them from biting on the tube, it must be removed and cleaned or replaced every eight hours. -If the tube is taped to the patient’s face, the tape must be removed and replaced on the opposite side of the face at least once per day . -The amount of air in the cuff should be checked every eight hours to ensure that the cuff is not exerting too much pressure on the trachea walls. -ETT should be confirmed to be the same as prior to the procedure

Endotracheal tube care Tray
This includes -a sterile suction kit; (two separate suction catheters for oral and ETT) -a bottle of sterile 0.9% sodium chloride; -sterile gloves; -a clean bite block, and -tape torn into appropriately sized pieces. Nursing Care of the Tracheostomy Tube -Tracheostomy (trach) care should be done every eight hours and involves cleaning around the incision, as well as replacing the inner cannula if the patient has a double-lumen tube. -prevent breakdown of the skin surrounding the site, and prevent infection. -Using sterile technique, the skin and external portion of the tube is cleaned with hydrogen peroxide. - inner cannula must be cleaned with hydrogen peroxide, rinsed with % sodium chloride, and reinserted using sterile technique

Sterile suctioning - Suctioning should be performed only when the patient needs it; the need should be assessed at least every two hours. - Pre-oxygenation with 100% O2 - two separate suction catheters for oral and ETT - size of suction catheter should be 1/3rd of ETT diameter - Duration of each suction pass should be limited to ten seconds -The number of passes should be limited to three or less - saline installation should not be used routinely

Eyes Eyes should be covered with a sterile gauze after applying a eye ointment. This is to avoid dryness of cornea & subsequent development of any ulceration.

Naso gastric tubes Instituted for gastric decompression
Administration of medications. Nutritional support Should be irrigated every 4 hours. Position should be verified before administration of any fluids. After administration flush with 10ml of water.

Care of Bladder Continuous bladder drainage
Catheter should changed once in 72 hours – check patency

GIT Care Oral cavity examination Abdominal Examination
Per Rectal Examination

Care to avoid development of bed sore
Constant changing position of patient Avoid pressure points Alpha bed or Water bed

Psychological care Good communication
Alleviate anxiety and promote emotional well being Orientation of patient to surrounding, Time and Persons

Sedation & Neuromuscular Blockade

Sedation & Neuromuscular Blockade
-Patients require sedation in order to tolerate mechanical ventilation Common Medications - sedatives decrease anxiety and produce amnesia - neuroleptics, - analgesics, and - paralytics SEDATIVES Lorazepam Midazolam Propofol Dexmedetomidine Onset of action minutes minutes minute Immediately Half-life hours hour < 30 minutes hours Loading Dose mg/kg mg/kg mg/kg mcg/kg Infusion rate mg/hr mg/hr mg/kg/hr mcg/kg/hr

NEUROLEPTICS -Given to patients who are experiencing delirium or “ICU psychosis.” Symptoms -disorganized thinking, - audio and visual hallucinations, and - disorientation. Haloperidol - intravenously in 2-10 mg doses every 2 to 4 hours ANALGESICS Intravenous narcotics – Morphine,fentanyl or hydromorphone PARALYTICS AGENTS or neuromuscular blocking agents (NMBs) - must always be administered with other sedatives and narcotics Two classes of NMBs: Nondepolarizing (Succinylcholine – for intubation) - Depolarizing ( Atracurium,Pancuranium,Vecuranium)

Assessment Criteria

Assessment Criteria Breath Sounds
- Breath sounds should be assessed at least every four hours Crackles (rales) Rhonchi Wheeze Pleural friction rub Spontaneous Respiratory Rate and Tidal Volume -If the spontaneous tidal volume is low -the patient may not do well with weaning attempts. -If the respiratory rate is high, particularly with weaning modes indicate the patient isn’t tolerating the mode, -needs suctioning, -or he or she is anxious or trying to communicate. Pulse Oximetry -The machine detects the percent of hemoglobin that is fully saturated pulse oximetry can be a helpful guide when titrating FIO2 -In general, a SpO2 of 92% in white patients, and 95% in black patients indicates adequate oxygenation (PaO2 > 60 mmHg).

(Capnography) End Tidal CO2
-Capnography, also called end tidal CO2, is CO2 measured at the end of exhalation -a display where a waveform (capnogram) is created, along with a number that closely approximates the PaCO2 -In a hemodynamically stable patient with a normal ventilation/perfusion relationship, the end tidal CO2 (also called PetCO2) is generally 1-5 mmHg less than the PaCO2 -The most useful function of end tidal CO2 measurement is to confirm ETT placement in the lungs.

Arterial Blood Gases (ABG)
pH • Normal pH of body fluids = • pH < 7.35 = acidosis • pH > 7.45 = alkalosis PaCO2 • PaCO2 is the partial pressure of dissolved CO2 in blood. • Normal = mmHg • PaCO2 is directly related to rate and depth of respiration. It’s a direct indicator of the effectiveness of ventilation. • As PaCO2 rises, the blood becomes more acidic and pH drops. • As PaCO2 decreases, the blood becomes more alkaline and pH rises. • If a change in PaCO2 is the primary alteration, then a respiratory problem exists. HCO3 • Bicarbonate (HCO3) is the primary buffer in the body and is able to take up and release H+. • Normal = mmHg • As HCO3 rises, the blood becomes more alkaline and pH increases. • As HCO3 drops, the blood becomes more acidic and pH decreases. • If a change in HCO3 is the primary alteration, then a metabolic problem exists.

CO2 • Considered a measure of bicarbonate concentration; includes total of bicarbonate and carbonic acid. • Normal = mEq/L Base Excess/Deficit • Measures excess amount of acid or base present in blood. This is independent of changes in PaCO2; therefore, it’s a measure of metabolic acid-base balance. • Increased HCO3 = base excess (alkalosis) • Decreased HCO3 = base deficit (acidosis) PaO2 • The amount of oxygen dissolved in plasma (about 3% of total; the other 97% is bound to hemoglobin). • Normal is mmHg in healthy young people breathing room air at sea level; this decreases with age and altitude. • PaO2 > 60 mmHg is considered acceptable in critically ill, mechanically ventilated adults

Figure out the ABG results
pH 7.30, PaCO2 40, HCO3 18 Metabolic acidosis (pH , PaCO2 ok, HCO3 ) 2. pH 7.48, PaCO2 30, HCO3 24 Respiratory alkalosis (pH , PaCO2 , HCO3 ok) 3. pH 7.25, PaCO2 54, HCO3 26 Respiratory acidosis (pH , PaCO2 , HCO3 ok) 4. pH 7.50, PaCO2 42, HCO3 33 Metabolic alkalosis (pH , PaCO2 ok, HCO3 )

Weaning and Extubation

Indications for weaning and extubation:
The patient is able to ventilate The patient is able to oxygenate The patient is able to protect his/her airway

Suitability for Weaning
Criteria Description Objective measurements Adequate oxygenation (eg, PO2 >60 mm Hg on FIO2 > 0.4; PEEP <5–10 cm H2O; PO2/FIO2 >150–300); Stable cardiovascular system (eg, HR <140; stable BP; no (or minimal) pressors) Afebrile (temperature < 38°C) No significant respiratory acidosis Adequate hemoglobin (eg, Hgb >8–10 g/dL) Adequate mentation (eg, arousable, GCS >13, no continuous sedative infusions) Stable metabolic status (eg, acceptable electrolytes) Subjective clinical assessments Resolution of disease acute phase; physician believes discontinuation possible; adequate cough

INTOLERENCE TO WEANING
Increased HR Increasrd RR (>30/mt) Increased work breathing Sweating (Hypercapnia) Hypertension Hypoxia

Weaning / Discontinuation of Mechanical Ventilation
I wish to evaluate the patient for discontinuation from the ventilator Place the patient on a Spontaneous Breathing Trial Watch for 5 or 10 minutes If acute distress does not occur, continue for a maximum of 2 hours Weaning / Discontinuation of Mechanical Ventilation Does the patient meet criteria? How do I know if the patient is tolerant intolerant of the trial? Is the patient suitable for extubation?

Weaning / Discontinuation of Mechanical Ventilation
Other Factors Is the patient suitable for extubation? Rest the patient on the ventilator Ensure optimal analgesia and sedation Reassess failure to wean/discontinue Attempt Spontaneous Breathing Trial ONCE every 24 hours Recurrent Failure Consider Tracheostomy: requiring excessive sedation to tolerate ETT marginal mechanics psychological dependence on ventilator mobility airway trauma. Weaning / Discontinuation of Mechanical Ventilation No Yes Sit the patient up in the bed, suction out the endotracheal tube, explain what you are going to do and extubate the patient. Failure to Ventilate Failure to Oxygenate Other Factors

Partial Ventilation Support
Weaning & Extubation Partial Ventilation Support Normalization of inspiratory times Driving pressure is targeted to a tidal volume of 4 - 6ml/kg. Mean airway pressure, the CPAP level and the FiO2 are reduced to targeted PaO2 As PaCO2 reduces reduce the controlresp.rate

Failure to Wean

Failure to Wean: Is the patient able to ventilate?
I wish to evaluate the patient for discontinuation from the ventilator Does the patient meet criteria? Place the patient on a Spontaneous Breathing Trial Watch for 5 or 10 minutes How do I know if the patient is tolerant /intolerant of the trial? If acute distress does not occur, continue for a maximum of 2 hours Is the patient suitable for extubation? Yes No Sit the patient up in the bed, suction out the endotracheal tube, explain what you are going to do and extubate the patient. Rest the patient on the ventilator Ensure optimal analgesia and sedation Failure to Ventilate Failure to Oxygenate Reassess failure to wean/discontinue Other Factors Attempt Spontaneous Breathing Trial ONCE every 24 hours Recurrent Failure Consider Tracheostomy: requiring excessive sedation to tolerate ETT marginal mechanics psychological dependence on ventilator mobility airway trauma Failure to Wean: Is the patient able to ventilate? Is the patient able to oxygenate? What other factors influence weaning?

Is the patient able to ventilate?
FACTORS THAT MAY INTERFERE WITH WEANING Neurological Anatomical Problems

Is the patient able to oxygenate?
Diffusion abnormalities, ventilation-perfusion mismatch, dead space and shunt. Certain factors may limit successful weaning - persistent lower respiratory tract infection, -alveolar edema, -airway/lobar collapse, -lung fibrosis.

What other factors influence weaning?
Cardiovascular – pulmonary edema,fluid overload Gastroinestinal – recurrent aspiration pneumonitis, ascites or abdominal wounds leading to diaphgramatic splinting Nutrition -protein malnutrition leading to muscular atrophy, which affects the diaphragm and intercostals Acid base – metabolic alkalosis reduces respiratory drive. Conversely, muscles perform poorly in an acidic environment Electrolytes– hypophosphatemia, hypomagnesemia, hypokalemia, hypocalcemia: these all affect muscular function and protein metabolism. Endocrine – muscle weakness due to hypothyroidism or steroid induced myopathy. Oxygen delivery capacity – the circulating hemoglobin concentration: anemia increases respiratory drive and cardiac output Pain control – it is very difficult to wean patients who are in pain

Weaning & Discontinuation Algorithm
Removing a patient from a ventilator involves discontinuation of mechanical ventilation and extubation. There are two parts to weaning: weaning to partial ventilator support and weaning to discontinuation. The single most traumatic event for the patient is conversion from positive pressure to negative pressure ventilation. To extubated a patient, they need to be awake, able to cough and protect their airway. If it is possible to wean a patient to extubation, but the patient cannot protect his/her airway, it is best to perform tracheotomy.

6. For a patient to self ventilate, many body systems must be functioning:
-the cardiopulmonary apparatus, -the central nervous system, -the nerves that supply the diaphragm (including the neuromuscular junctions), -the muscles themselves. -Moreover the patient must be willing to breath and maintain their own functional residual capacity (not if there is diaphragmatic splinting due to pain). -There must be room in the abdomen for the diaphragm and lungs to move into. -There must be adequate hemoglobin to deliver oxygen to the tissues. 7. Difficult to wean a patient if ongoing inflammatory processes persist in the lungs: consolidation, fibrosis, auto-PEEP, diffusion defects 8. Muscles must be trained and nourished, and patient-ventilator interaction encouraged 9. most effective method of weaning to discontinuation is spontaneous breathing trials (SBT). SBTs should not be performed more than once daily.

Methods of weaning

There are three primary methods T piece/CPAP trials,
Methods of weaning There are three primary methods T piece/CPAP trials, Synchronized Intermittent Mandatory Ventilation (SIMV), Pressure Support Ventilation (PSV). PSV is often used with SIMV to decrease the work of breathing.

T-piece/CPAP trials CPAP
-T-piece trials consist of alternating intervals of time on the ventilator with intervals of spontaneous breathing. -T-shaped tube is attached - endotracheal or tracheostomy tube tubing is attached to an oxygen flowmeter -the other end is open -watch for signs of hypercapnia Tachycardia Tachypnoea Sweating Hypertension CPAP - With CPAP, the patient breathes spontaneously, but has the benefit of the ventilator alarms if he or she has difficulty. - CPAP maintains constant positive pressure in the airways, which facilitates gas exchange in the alveoli.

SIMV -SIMV is a ventilator mode that delivers a preset number of breaths to the patient but coordinates them with the patient’s spontaneous breaths. -The ventilator may be set to deliver 12 breaths per minute, but the patient’s respiratory rate may be 16 (12 ventilator breaths plus 4 patient-initiated breaths). -The ventilator rate is usually decreased by one to three breaths at a time and an arterial blood gas (ABG) is obtained 30 minutes after the change Pressure support - Placing the patient on the pressure support mode at a level that allows the patient to achieve a spontaneous tidal volume of ml/kg. - During weaning, the level of PS is decreased by 3-5 cm H2O as long as the patient maintains the desired tidal volume.

Weaning criteria Simple bedside pulmonary function tests
Vital capacity (VC) -The vital capacity is the maximal amount of air that can be exhaled after a maximal inhalation. -The patient’s vital capacity should be at least cc/kg. Negative inspiratory force (NIF) -Negative inspiratory force is the ability to take a deep breath and to generate a cough strong enough to clear secretions. -The patient’s NIF should be at least –20 cm H20. Tidal volume (VT) -Tidal volume is the volume of air inspired and expired during a normal respiratory cycle. -The patient’s tidal volume should be at least 5 ml/kg

Minute volume (VE) -Minute volume is the total volume of air inhaled and exhaled in one minute. -The patient’s minute volume should be less than 10 liters per minute. Respiratory rate (RR) -The respiratory rate is the number of breaths per minute. The patient’s RR should be less than 25 breaths/minute. Arterial blood gas (ABG) -An ABG should be done before the patient is extubated. The PaO2 should be at least 50 mmHg on less than 50% oxygen and with no more than 5 cm H20 PEEP.

Post - Extubation Care

Post-Extubation Care Humidified oxygen -Supplemental oxygen requires humidification to prevent drying and irritation of the respiratory tract and to facilitate removal of secretions. -oxygen delivered through a mask for a few hours after extubation. Respiratory exercises -coughing and deep breathing. -incentive spirometry exercises. IPPB -is used in some institutions to assist patients to take deeper breaths, especially after surgery. -The IPPB machine is a pressure-cycled ventilator that delivers compressed gas under positive pressure into the patient’s airway. -It’s triggered when the patient inhales, but it allows passive expiration.

-10-20 breaths are given every 1-2 hours for 24 hours.
-Benefits of IPPB -prevention of atelectasis, -promotion of full-lung expansion, -improved oxygenation, and -administration of nebulized medications Assessment and monitoring - Breath sounds, pulse oximetry, and vital signs should be assessed and recorded every 15 minutes x 1 hour, every 30 minutes x 1 hour, then every hour until stable - ABG to be done minutes after extubation -Don’t forget to ask the patient how his or her breathing feels

Thanks to your expert nursing care

VENTILATOR THE BASIC- COURSE.

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