1. Combating the Opioid Abuse Epidemic with Evzio ® (naloxone) Baely Crockett, PharmD Eskenazi Health Internal Medicine PGY2 This speaker has no actual or potential conflicts of interest to disclose in relation to this presentation.

2. 43,982 Drug Overdose Deaths in 2013 Centers for Disease Control and Prevention. CDC’s top ten: 5 health threats in 2014. Centers for Disease Control and Prevention. Injury prevention & control: prescription drug overdose.

3. Drug Overdose Deaths in Indiana Indiana State Department of Health. Special emphasis report: drug overdose deaths. 2014.

4. Opioid Mechanism of Action and Abuse University Of Florida. Opioids: mechanism of action.

5. Treatment of Opioid Overdose Naloxone and overdose prevention education program of Rhode Island.

6. Naloxone Routes of administration Intravenously Intramuscularly Subcutaneously Intranasally Nebulizer Naloxone. LexiComp. 2015 Kaleo, Evzio. 2015.

7. What is Evzio®? Hand-held, single-use naloxone auto-injector Intramuscularly or subcutaneously Outer thigh Holds 0.4 mg of naloxone User-friendly with audio instruction on appropriate administration Does not replace need for emergency medical assistance Kaleo, Evzio. 2015.

8. Audience Participation Who can administer Evzio? A.Patients prescribed high doses of opiates B.Family members of patients who are prescribed high doses of opiates C.Health care professionals working at a pain management clinic D.All of the above Kaleo, Evzio. 2015.

9. How to use Evzio ® 1.Remove cap 2.If ready to use, pull off red safety guard 3.To inject, place black end against outer thigh then press firmly and hold in place for five seconds 4.Counts down from five to one Kaleo, Evzio. 2015.

10. How to use Evzio® (cont’d) 5. Injection complete 6.Seek emergency medical attention 7.This device has been used and should be taken to your physician for proper disposal and a prescription refill Kaleo, Evzio. 2015.

11. Increased Access to Naloxone Kaleo, Evzio. 2015. ProsCons Frontline personnel would be able to treat patients faster to save lives Abusers may try higher doses, knowing reversal is at their fingertips

12. Combating the Opioid Abuse Epidemic with Evzio ® (naloxone) Baely Crockett, PharmD Eskenazi Health Internal Medicine PGY2 This speaker has no actual or potential conflicts of interest to disclose in relation to this presentation