1. Welcome to TypeOneNation 2014

2. The Plan for a World without T1D Presented by: Carol Oxenreiter Saturday, May 31, 2014

3. JDRF’s Vision for the Future 3 FOR A WRLD WITHOUT TYPE 1 DIABETES

4. 4 LESS UNTIL NONE

5. 5 LESS UNTIL NONE LESS LESS UNTIL NONE Burden Invasive Complexity Danger

6. 6 Delivery of Continuous Therapeutic Improvements Side-Effects Complications Patient Burden Glycemic Control Safety Normal Physiology Restored TherapiesCure Easier, Safer, Less Worry, Better Life

7. The Plan: Work the Pipeline 7 DELIVERY TO PATIENTS

8. 8

9. Artificial Pancreas A series of systems that will automate insulin dosing and additional hormone delivery

10. Artificial Pancreas A series of systems that will automate insulin dosing and additional hormone delivery Smart Insulin Single dose of insulin that delivers insulin only where and when needed

11. Artificial Pancreas Single dose of insulin that delivers insulin only where and when needed Smart Insulin Encapsulation Implantable, beta cell replacement therapies restoring insulin independence without the need for intensive immune suppression

12. Artificial Pancreas Smart Insulin Encapsulation Encapsulation Implantable, beta cell replacement therapies restoring insulin independence without the need for intensive immune suppression Prevention Slow or stop the progression of T1D before insulin dependence and ultimately eliminate the possibility of ever developing T1D

13. Artificial Pancreas Smart Insulin Encapsulation Prevention Prevention Slow or stop the progression of T1D before insulin dependence and ultimately eliminate the possibility of ever developing T1D Restoration Beta cell growth protected from immune attack restoring insulin independence without immune suppression

14. Artificial Pancreas Smart Insulin Encapsulation RestorationPrevention Restoration Beta cell growth protected from immune attack restoring insulin independence without immune suppression

15. Artificial Pancreas Smart Insulin Encapsulation RestorationPrevention

16. Continuous Therapeutic Improvements NEAR TERM Complications Diabetic Eye Disease Predictive Diagnostics Artificial Pancreas Low Glucose Suspend Treat-to-Range MID TERM Encapsulation Treat-to-Target Multihormone Encapsulation Implantable Islets Smart Insulin Control Prevention Secondary Prevention LONG TERM Prevention Primary: Vaccine Complications Comprehensive Prevention Therapy Restoration New Beta Cell Growth Protected from Immune Attack

17. DELIVERY TO PATIENTS

18. Capabilities Across All Stages of the Pipeline DELIVERY TO PATIENTS $500 Million Research Portfolio Broad and Diverse Portfolio Artificial PancreasRestorationSmart InsulinEncapsulationPrevention

19. DELIVERY TO PATIENTS Capabilities Across All Stages of the Pipeline Research and Development Expertise

20. DELIVERY TO PATIENTS Capabilities Across All Stages of the Pipeline Volunteer Engagement

21. Capabilities Across All Stages of the Pipeline International Reach DELIVERY TO PATIENTS

22. Capabilities Across All Stages of the Pipeline Partnership DELIVERY TO PATIENTS

23. Your Support Capabilities Plan Vision

24. 24