2. ارائه دهنده : دکتر اکرم جوکار
Case report
ارائه دهنده : دکتر اکرم جوکار

3. بیمار آقای 28 ساله که با شکستگی خودبخودی استخوان بازو به این مرکز مراجعه کرده.شرح حال وی سابقه ای از درد بازو از 4 ماه قبل ذکر می کند به طوری که قادربه حرکت دست خود نبوده از 3 روز قبل از مراجعه بیمار به طور ناگهانی و در حالت استراحت دچار تشدید درد می شود که به ارتوپد مراجعه می کند و طی گرافی انجام شده به علت شکستگی استخوان بازوبرای وی آتل گرفته می شودو به این مرکز ارجاع داده می شود. بیمار سابقه ای از تروما در این مدت اخیر ذکر نمی کند .
همچنین 6 ماه قبل بیمار به علت LAP آگزیلاری دست چپ به پزشک مراجعه می کند که به گفته ی بیمار LAP وی بدون درد ، قرمزی و گرمی بوده که نهایتاً بیمار تحت بیوپسی قرار گرفته و در پاتولوژی وی Kikuchi necrotizing lymphadentis گزارش شده.
در طی این مدت بیمار شکایتی از تب ، لرز ، تعریق و کاهش وزن را ذکر نمی کند. تنها یک درد مختصر پای چپ را از یک ماه پیش تاکنون ذکر می کند.

4. در معاینات بیمار ملتحمه pale نبود. اسکلرا icteric نبود
در معاینات بیمار ملتحمه pale نبود . اسکلرا icteric نبود .LAP گردنی SupraclaVicular. واینگوئینال لمس نشد . ارگانومگالی لمس نشد
.بازوی سمت چپ به علت شکستگی آتل گچی گرفته شده بود.
معاینه سایر اندام ها NI بود .

5. WBC: ESR: WBC: 69000
Hb: uric Acid : Hb: 12.2
Mcv: Cr : MCV : 64
Mch : Ca : MCH : 24
PLT : P : PLT :
AST:73
ESR : ALT:29
LDH: CRP : +++
CRP : ALP:325

6. سی تی اسکن ریه و مدیاستن نرمال گزارش شده
سی تی اسکن شکم و لگن:
کبد و طحال پاراآئورت نرمال گزارش شده تنها ندولی به قطر 3 cm
در قدام عضله پسواس چپ در لگن مشاهده شد که قابل افتراق از سیگموئید نمی باشد.

14. A large tissue mass(7*6 cm)in the proximal left arm with bone marrow edema in the proximal metaphisial of humerous is seen

16. Abnormal increase uptake is seem in upper portion of left humerus-upper portion of left femur.reminder of skeleton is visualized with normal uptake
Imperison:
1-Active lesion inmention region
2- bone scan finding high suggestive with bone metastase or systemic bone disease

17. Pathology :
Malignant lymphoma,diffuse large cell type left arm
IHC
CD20 +
CD3 + Positive In Some Background Lymphocyte
CD 45 +
CD 99 +

18. Differential Diagnosis
Osteosarcoma Osteosarcoma is the most common primary malignant tumor arising in bone (myeloma excluded). Osteosarcoma, which is most common in the second and third decades of life, is usually a high-grade malignancy, . There is usually a mixture of radiodense and radiolucent areas, with periosteal new bone formation, and sometimes formation of Codman's triangl

19. Ewing sarcoma
The characteristic periosteal reaction produces layers of reactive bone, deposited in an "onion peel" appearance .

20. Other tumors
– Other malignant tumors that should be considered in the differential diagnosis of a primary lytic lesion include: fibrosarcoma (spindle cell sarcoma), which tends to resemble osteosarcoma but without ossification, primary lymphoma of bone metastasis from a non-bone tumor

21. .
"Benign" bone tumors that can present as lytic lesions include:
hemangioma,
various types of cysts,
lipomas,
eosinophilic granuloma
giant cell tumor of bone.
Destructive eosinophilic granulomas usually occur at a younger age and are not associated with a sizable soft tissue mass

22. Primary bone lymphoma
Primary bone lymphoma (PBL) is an uncommon tumor accounting for approximately 4-5% of extra nodal lymphoma and less than 1% of all non-Hodgkin's lymphoma.
Disease may be complicated at presentation by pathological fracture or spinal cord compression. Diffuse large-B-cell lymphoma (DLBCL) accounts for the majority of cases of PBL.

23. To be defined as primary bone lymphoma (also known as Coley's criteria), there should be [4] (i) a primary focus in a single bone (ii) positive histological diagnosis (iii) no evidence of distant soft tissue or distant lymph node involvement.
it is recognized that primary bone lymphoma may involve multiple bones, as long as the other two criteria are met

24. PBL occurs commonly between 20 and 50 years of age and shows male preponderance with male to female ratio of 3:2.
The femur (29%) is the most common site followed by (in descending order of frequency): pelvis (19%), humerus (13%), skull (11%) and tibia (10%).

25. Clinical presentation
Clinical presentation includes local pain and swelling. Radiologically bony lesions may be extensive, destructive or infiltrative.
Extensive lesions involve 25-50% of affected bone, sometimes entire bone.
Destructive lesions are radiolucent, mottled, patchy, moth eaten and sometimes the outline of the bone is completely lost

26. Nearly all variants destroy cortical bone and 25% thicken the cortex.
Often large, obvious soft-tissue extension may be present along with bony lesion.
Diagnosis is established by biopsy.

27. Other investigations include
skeletal survey, bone scan, bone marrow biopsy, CT scan of whole abdomen and chest to assess lymph node involvement and serum LDH estimation are done as part of the staging procedure.
MRI is helpful in demonstrating bone marrow and soft tissue involvement.
Lymphoma has an increased uptake on bone scan.

28. treatment
Over the last two decades, chemotherapy (CHOP based) has become the standard treatment with or without consolidative irradiation.
The introduction of rituximab since March 2001 has been accompanied by a remarkable improvement in the PFS for patients with PBL compared with those treated earlier without rituximab (3-year PFS 88% versus 52%).
Role of radiation in advanced stage PBL is controversial.
Surgery is only indicated for pathologic fractures

29. Thus, primary lymphoma of bone should be considered in the differential diagnosis of bony tumors in young patients in second to fourth decade. Chemotherapy followed by radiotherapy is the treatment of choice and is associated with good outcome

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