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Published byRhoda Joseph Modified over 8 years ago
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Connective Tissue(C.T.) The mesodermal ………………. to mesenchymal tissue(undifferentiated mesenchymal cells&hemogenous intercellular substance of proteins The mesenchymal tissue are differentiated in the embryo into 1-connective tissue C.T. 2-vascular tissue 3-smooth muscle
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The connective tissue formed of A-C.T. cells B-C.T. fibers C-C.T.matrix
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Types of C.T. According to the nature of intercellular matrix we have 3 types of connective tissue 1-C.T. proper( soft matrix) 2-cartilage (rubbery matrix) 3-Boney ( solid matrix)
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1-Connective tissue proper It is called connective because is support,binds&connection various tissue and organs
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The C.T. is formed of 1-C.T. cells 2-C.T.fibers 3-Soft matrix or ground substance
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Types of connective tissue proper The cells &C.T. fibers are present in the soft C.T.
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6 (Six)Types of C.T. Proper 1-areolar C.T. 2-yellow elastic C.T. 3-Mucoid C.T. 4-White collagen C.T. 5-Adipose C.T. 6-Reticular C.T.
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Types of Connective tissue cells 1-Fixed C.T. cells as 2-Free C.T.Cells
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1-Fixed C.T. cells as: 1-fibroblast, 2-fixed macrophages, 3-fat cells, 4-mesenchymal cells, 5-pericyte cells, 6-endothelial cells 7-reticular cells
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Fibroblast&Fibrocytes Cells -develop from mesenchymal cells&pericytes -It is very numerous in areolar C.T. -basophilic cytoplasm -The cytoplasm is rich in RNA,ER,GA,Mitochondria -fibroblast can divide -Fibroblast can changes into myofibroblast
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Function of Fibroblast - Form collagen,elastin&reticulin substances in order to form C.T.fibers -Form the mucoprotein of the C.T. matrix increase number during healing of wounds Fibroblast change into myofibroblast which close wounds
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Fibrocytes === mature fibroblasts - Small spidle shaped cells with dense nuclei - Acidophilic cytoplasm -can not divide
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LM of fibroblasts (arrows)
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SEM of fibroblasts
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2-Fixed macrophages or histocytes cells -dervied from blood monocytes - more present in the damaged C.T. -have irregular cell membrane -cytoplasma is not clear-rich in lysosomes -the nucleus is small,kidney shape -Histiocytes cells can be stained with vital stain as trypan blue
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Function: -Defence mechanism of the body -can engulf(eat)foreign bodies,bacteria and old blood cells -can clean wound from foreign bodies&debris -can transport antigens -macrophage………multinucleatd gint cells…..enclose large foreign bodies in order to destroy them
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3-Adipose cell or fat cells or adipocytes -derived from mesenchymal cells - flat peripheral nucleus -there are 2 types of fat cells 1-unilocular white fat cells 2-multilocular brown fat cells -Fat cells can not divide Stained : orange with sudan III,black sudan black
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Function -brown fat responsible for energy reservoir&heat production -white fat cells release energy during starvation - support organs as kidney -they act as heat insulator
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4-The Mesenchymal Cells(UMC) -embryonic branched cells called(UMC) -has large oval nucleus&basophilic cytoplasma -present in the embryonic tissue Function: Can differentiate into other types of C.T.
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5-The Pericyte cells -pale branched cells(peri= around) -present immediate external to the endothelium of blood vessels capillaries&small venules -persistent in adult life
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Function: Give rise to both fibroblast&smooth muscle cells -role in the process of healing of connective tissue -modified to form myoepithelial cells which can contract
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6-The Endothelial Cells Present in the surface of blood capillaries&blood vessels -develop from the embryonic mesenchymal cells
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Function: 1-synthesise collagen(type 4 collagen) 2-can form the basal lamina of the endothelium 3-divide rapidly.. give rise..endothelial cells of lung capillaries to secret angiotensin converting enzyme
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7- Reticular Cells -present in mainly in the reticular C.T. -modified fibroblast which are specialized to secrete reticular fibres -reticular cells are found in the stroma of bone marrow,lymph nodes,spleen,liver,pancreas
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Function: Supportive&phagocytic cells -form the stroma of glands&bone marrow -removal cellular debris from the lymphatic tissue
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2-Free C.T. Cells 1-Mast Cells 2-Plasma Cells 3-Free Macrophages, 4-Blood Leucocytes 5-Melanophore Cells
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1-Mast Cells 2-Histamine secretory mast cells Present under mucosa of respiratory &digestive tract Histamine…………….contract smooth muscle Dilated blood vessels capillaries Increased the capillary permeability
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-Small cells,round,irregular in shape -present in groups blood vessels Types of mast cells 1-Heprin secretory mast cells Present in the C.T. of skin,secret heprin which is an anticoagulant
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TEM of a Mast Cell
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LCT – M = mast cell; P = plasma cells; F = fibroblasts; Eo = eosinophils, N = neutrophils
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Function: -Secrete heparin or histamine (paracrine cells) -release chemical mediators as immediate hypersensitivity Factors which may cause of anaphylactic shock
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2-Plasma Cells Present peritoneum, submucosa of digestive respiratory tract, lymph nodes&spleen -originate from plasmablast cells which develop from B-lymphocytes -small&round with hemogenous basophilic cytoplasm
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Function: -secrete specific antibodies against organisms&foreign bodies antibodies circulate in the blood termed(humoral antibodies)&processes is called humoral immunity -Can not divide -Have no phagocytic activity
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3-Free Macrophages -derived from blood monocytes after their migration to C.T. -their cytoplasma is rich in lysosomes&RER -they have oval eccentric nuclei
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Function: -Immun system of the body -they are highly phagocytic cells -secrete collagenase&elastasa enzymes&lysozome -kill certain viruses through secretion of interferon
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4-Bolood Leukocytes Appear normaly in the C.T.of the following body organs -Eosinophils&basophils Found in C.T. of respiratory intestinal&female genital tract -they increase in allergic condition
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-Lymphocytes&monocytes Present in many organs -increased in number in chronic infections -Neutrophils: -They migrate from blood vessels of C.T. -where acute infection is present in order to phagocytose microorganism
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5-Melanophore pigment cells -They are C.T.macrophages which phagocytose melanin Pigments are formed by the melanocytes -melanophores are branched cells with small round nuclei -melanophore are rich in melanin pigments
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Function: -They carry melanin pigments
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Types of C.T.Fibers There are three(3) types of C.T. 1-white collagennous fibers 2-yellow elastic fibers 3-reticular fibers
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1-White Collagenous Fibers Shape: colourless wavy branching bundles,the fibers run paralled to each other Charcter: soft,strong&flexible but not elastic fibers
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Structures: formed of protein known as (collagen) which can be digested by pepsin&trypsin enzymes Staining: collagenous fibers are acidophilic,stainpink with eosin,red in van-Gison&blue with Mallory stain
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Types of collagen There are five(5) types of collagen 1-Type I collagen: Present: losse C.T.,White fibro-cartilage,bone&teeth this type is formed by fibroblast,osteoblast,odontoblast 2-Type II collagen: hyaline&elastic cartilage&formed by chondroblast
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3-Type III collagen: skin,smooth muscle&reticular fibers formed by fibroblast&by smooth muscle cells 4-Type IV collagen: present in the basement membrane of epithelial tissue&lenes of eye,It formed by fibroblast&by endothelial cells 5-Type V collagen: in placenta,it is formed by fibroblast
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2-Elastin fibers Shape: fine,straight branching fibers Carachter: the fibers branched&anastomose with each other They run singly¬ in bundles Appear yellow in fresh state
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Structures: formed of protein known as elastin which is resistant to chemical and to boiling Can digested by the pancreatic elastase enzyme Staining: brown with orcein,black with verhoeff and yellow with van-Gison
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Orecin Stain for Elastin – purple “ribbon candy”
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3-Reticular Fibers Shape: they are thin,branched anastomose to form anetwork or reticulum Strucures: -formed of protein known as collagen type III -Staining: Black with silver
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Sliver Stain for Reticular Fibers
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PAS stain of epithelial basement membranes (BM)
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TEM of collagen fibers with 64 nm periodicity
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TEM of extracellular collagen fibers (Cl)
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Masson’s Trichrome Stain – blue = collagen
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Areolar Tissue Pink = collagen Purple = elastin
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TEM of a Plasma Cell
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TEM of a Macrophage
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Types of C.T. Proper 6 types of C.T.proper The 12 types of c.t. cells and the 3 types of c.t. fibers are present in soft matrix of mucopolysacchrids to form the
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following 6 types of C.T. proper 1-Areolar C.T. 2-Adipose tissue 3-Yellow elastic C.T. 4-White Collagenous C.T. 5-Reticular C.T. 6-Micoid C.T.
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1-Areolar C.T. Commone type in the human body contain all types of C.T.fibers&C.T. cells Function:packaging material for other tissue Structures: formed of aloose matrix formed of mucopolysacchids contain areolar(spaces)filled with air or fluid C.T. cells&C.T. fibers are embedded in the loose matrix C.T. cells are mainly fibroblasts,macrophages,fat &mast cells C.T. fibers are mainly collagenous which are found in dermis of skin
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Sites: 1-submucosa of digestive tract 2-Present in all over the body except brain tissue&under dermis of skin 3-pleura,peritoneum&pericardium 4-under epithelial lining of organs 5-around the organs&blood vessels
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2-Adipose C.T. The fat cells develop from(UMC) transformed in lipoblast then into fat cells
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There are 2 types of adipose C.T. A.White Adipose Tissue B.Brown Adipose tissue
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A-White adipose tissue Composed of large fat cells These fat cells have eccentric flat nuclei -the rim of cytoplasm around the nuclei contain few cell organelles These fat cells can form fatty acids from glucprotien processes is regulate by hormones as insulin This type affect by hormones&by the restriction of diet(regime)
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Function of White Adipose C.T. -Heat insulator&fat storge areas Gives the body normal shape Sites: 1-under the skin(im female)present in mammary glands&gluteal region 2-Around the kidney&blood vessels 3-in mesentry,omentum,abdominal wall
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B-Brown adipose C.T. Formed of small fat cells filled with many droplets of pigmented lipid Develops mainly in the emroyo from UMC.persist for few months after birth,supplies new born infant with heat to protect them from cold
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Function: Heat generator,gives,heat to the different body organs Site: Interscapular region,axillary region,mediastinal around the thoracic aort Present: Eyelid,lung
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Present: Eyelid,lung 3-Elastic C.T. Appears yellow when present in afresh condition -stained brown with orecin stain -elastic fibers separated with areolar C.T. -elastic tissue stretchable -elastic tissue is present in the form of elastic membranes as in aorta Site: -aorta&large arteries -bronchi,bronchiles&around alveoli of lung -ligment nuchae(in the back of the neck)to facilitate movments of trunk&neck
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