1. Iatrogenic Anemia in the ICU Anh Nguyen, MD, MPH, PGY2

2. Background Patients who were admitted to the ICU need to have a lot of blood tests related to their illness and for further treatment. However, that can cause decrease Hgb/Hct or iatrogenic anemia. Conflicting evidence of the association between anemia among ICU patients and excessive diagnostic blood draws. The increased laboratory use leads to increasing other costs such as electrolyte repletion, blood transfusion (in patients with anemia attributable to laboratory testing). These higher costs did not have significant different ICU lengths of stay or hospital mortality.

3. Methodology Cross-sectional study, patient charts review Inclusion criteria: ICU stay > 3 days Exclusion criteria: ICU stay < 3 days, GI bleed, trauma bleeding, pancytopenia, pulmonary hemorrhage Main variables: baseline Hgb/Hct, Hgb/Hct when leave the ICU, length of stay in the ICU Effect modification variable: Anemia of chronic disease

4. Methodology Reviewed 33 ICU charts Included 15 charts in the study Excluded 18 charts based on exclusion criteria

5. Analysis Using SAS Student t-tests

6. Results

7. Conclusion This cross-sectional study showed that iatrogenic blood loss for laboratory investigation is one of the causes of anemia in the ICU. Physicians should only order phlebotomy for necessary investigation and for the most effective of diagnosis and treatment.

8. Discussion Lack of evidence of benefit of the current practice of frequent laboratory testing in the ICU. Excessive costs, potential risks, and no proof of benefit which mandates a re-evaluation of the current approach to routine laboratory testing in the ICU Unknown whether normalization of abnormal routine laboratory values compared to reference range among patients in the ICU confers net benefit. In addition to correcting abnormal laboratory values, there is a tendency to recheck laboratory tests after the intervention

9. Discussion Risks associated with transfusion: transmission of infectious agents, an increased risk of nosocomial infections, transfusion-related acute lung injury, transfusion-associated circulatory overload, and transfusion-related graft-versus-host disease Admission laboratory tests are valuable to establish baseline values for comparisons with later values Routine, undirected, daily laboratory evaluation (eg. homeostatic laboratory testing) is a practice of questionable utility, and efforts to reduce it are warranted

10. Plan for Improving Current Practice Small volume collection tubes Transfuse to maintain Hgb 7-9 g/dL Decrease the number of daily ABG’s, CMP’s, and CBC’s if possible Increase the intervals at which homeostatic laboratory tests are obtained (decrease from daily to every 3 days)

11. Plan for Improving Current Practice The practice of bundling multiple lab tests together (eg. BMP) should be abandoned Laboratory testing should be pursued as a part of therapeutic response to a clinical problem rather than as a search for abnormal values to be corrected. Testing in the context of higher pretest probabilities of disease should be emphasized Train ICU house officers to be thoughtful in ordering routine ICU laboratory tests during first-year orientation

12. References Ezzie ME, Aberegg SK, O’Brien JM. Laboratory testing in the intensive care unit. Crit Care Clin 2007;23:435-465. Shander A. Anemia in the critically ill. Crit Care Clin 2004;20(2):159-78 Tarpey J, Lawler PG. Iatrogenic anaemia? A survey of venesection in patients in the intensive therapy unit. Anaesthesia 1990;45(5)396-8. Tosiri P, Kanitsap N, Kanitsap A. Approximate iatrogenic blood loss in medical intensive care patients and the cause of anemia. J Med Assoc Thai 2010;93(7):S271-6.