1. Change in longest diameter = -19%

2. Change in sum of perpendicular diameters = -21%

3. Change in CT Volume = -37%

4. Change in PET SUVmax = -18%

5. Comparison of Response Measures Change in longest diameter = -19% Change in sum of perpendicular diameters = -21% Change in CT Volume = -37% Change in PET SUVmax = -18%

6. Standardized Uptake Value Under certain circumstances, 18 FDG SUV correlates with metabolic rate of glucose and/or the number of viable tumor cells Simplified semi-quantitative measure that can be routinely performed in clinical PET studies Adjusts for differences in patient size and injected activity SUV (time) = Radioactive Concentration x Weight Injected Activity

7. EORTC PET metabolic response criteria Complete response (CR): Complete resolution of all lesions Partial Response (PR): Greater than or equal to 25% decrease in SUVmax. Stable Disease (SD): Less than 25% change Progressive Disease (PD): Greater than or equal to 25% increase in SUVmax