1. Neuroimage Analysis Center An NCRR National Resource Center http://nac.spl.harvard.edu Viewing essentials GE Research § Isomics ¥ Surgical Planning Laboratory, Brigham and Womens Hospital James Miller, Ph.D.. James Ross, M.Sc., Xi Wang, Ph.D., Steve Pieper, Ph.D. §, Wendy Plesniak, Ph.D. ¥

2. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Requisites, expectations and adaptations Clinicians and researchers need and expect imaging platforms to provide stock capabilities Window/level Pan/zoom Annotation Probe Measurement Oblique reformat Volume rendering Lightbox How do we adapt these concepts to a Slicer experience?

3. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Lightbox http://www.brighamandwomens.org/excellence/neuroscience.a spx ?

4. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Standard lightbox viewing http://www.brighamandwomens.org/excellence/neuroscience.a spx

5. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center … with overlays

6. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center … with annotations

7. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center … with fiducials

8. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center … with multiple reformations

9. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center … with an editor X

10. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Oblique reformat Anatomy is rarely predominantly aligned axially, sagitally, or coronally Oblique reformation allows image display planes to be aligned to an anatomys principal axes Axial Oblique

11. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Standard oblique reformat CTRL-Right Button to manipulate reformation

12. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center … with lightbox

13. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Comparing series and studies Longitudinal analysis Cross-sectional analysis

14. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Standard comparison of studies

15. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center … with overlays

16. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center … with annotations

17. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center … with fiducials

18. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center … after registration

19. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center … with lightbox

20. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center … with oblique reformation

21. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Applications Atlas construction Manual delineation Quality control Cross-sectional comparison of atlas subjects before and after aligning to common coordinate frame Cross-sectional comparison of atlas subjects to constructed atlas Atlas application Comparison of atlas to new subject Cross-sectional comparison of new subjects aligned with atlas Longitudinal analysis Response to therapy

22. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Image viewing is still predominantly 2D Native format of acquisition Precision dimensional measurements Multiplanar reformat (axial, sagittal, coronal) provides a natural (perhaps comfortable) navigation paradigm Lightbox provides a mechanism to display 3D relationships Oblique reformats provide a mechanism to mitigate 3D effects (improve accuracy of dimensional measurements) Longitudinal and cross-sectional comparisons build on the same framework of linked controls and coordinate frames Slicer3 allows all these capabilities to be layered due incorporation of coordinate frames at a fundamental level of the viewing pipeline