1. THE CARDIOVASCULAR SYSTEM BLOOD THE HEART BLOOD VESSELS/CIRCULATION LYMPHATIC SYSTEM / IMMUNITY

2. REQUIREMENTS THIS SLIDE SHOW DOES NOT TAKE THE PLACE OF READING THE CHAPTERS AND TAKING NOTES ON YOUR OWN FOR QUIZZES OR THE TEST

3. BLOOD – WHAT IS IT? IT IS ACTUALLY A CONNECTIVE TISSUE (BUT MOVES) IT BRINGS NUTRIENTS AND OXYGEN TO CELLS AND CARRIES AWAY WASTE PRODUCTS (CO2) A THICK FLUID THAT CAN VARY IN THE RED COLOR BASED ON THE AMOUNT OF OXYGEN AN AVERAGE MAN HAS 5 LITERS IN THEIR BODY BLOOD VOLUME IS 8% OF TOTAL BODY WEIGHT

4. FUNCTIONS OF BLOOD TRANSPORTATION REGULATION PROTECTION

5. TRANSPORTATION Air comes into body, sent to all tissues CO2 breathed out Nutrients, electrolytes and vitamins transported Waste products carried to releasing organs such as kidneys and liver Hormones also transported

6. REGULATION PH of fluid kept about 7.4 Amount of fluid regulated by osmotic pressure Heat also transported to parts of the body from muscles.

7. PROTECTION DEFENSE – CARRIES CELLS AND ANTIBODIES FACTORS – HELP START THE CLOTTING PROCESS – CREATE A WEBBING (LIKE SPIDERWEBS) TO STOP THE FLOW OF BLOOD (SOMETIMES KNOWN AS FIBRIN)

8. CONSTITUENTS TWO MAIN COMPONENTS: – PLASMA – LIQUID – FORMED ELEMENTS – CELLS / CELL FRAGMENTS ERYTHROCYTES – RED BLOOD CELLS LEUKOCYTES – WHITE BLOOD CELLS (PROTECT FROM INFECTION – CREATE PUS THROMBOCYTES (PLATELETS) – BLOOD CLOTTING

9. BLOOD PLASMA OVER HALF THE TOTAL BLOOD VOLUME 90% WATER PROTEINS – NEEDED FOR GROWTH AND REBUILDING BODY TISSUES – ALBUMIN – MOST ABUNDANT PROTEIN – CREATED IN LIVER – FOUND IN EGG YOLKS AND PLACENTAS – CLOTTING FACTORS – ANTIBODIES – COMPLEMENT – HELP ANTIBODIES FIGHT INFECTION

10. BLOOD PLASMA (CON’T) Glucose is the main carbohydrate – Supplies energy to the body Amino Acids – Product of protein digestion Lipids (Fats) – small % of plasma Electrolytes – Salts – Ex: Sodium, Potassium, Calcium, and Magnesium – They help form bone, produce hormones, and maintain an Acid – Base balance for PH. – SODIUM POTASSIUM REGULATION IS VERY, VERY IMPORTANT IN BLOOD AND FEELING WELL.

11. ERYTHROCYTES (RED BLOOD CELLS) MATURE FORM IN BLOOD LACKS A NUCLEUS AS NEEDS ROOM TO CARRY OXYGEN OXYGEN BINDS TO HEMOGLOBIN IN THESE CELLS THIS BINDING GIVES THE RED COLOR OF BLOOD HEMOGLOBIN HELPS WITH PH AND CARRIES CO2 FOR WASTE RELEASE HEMOGLOBIN IS BLOCKED BY CARBON MONOXIDE – WHY YOU CAN DIE FROM BREATHING IN SMOKE AND CO.

12. ERYTHROCYTES (CON’T) MOST NUMEROUS OF BLOOD CELLS ERYTHROPOIETIN (HORMONE) – HELPS RELEASE NEW RED BLOOD CELLS INTO THE BODYS BLOODSTREAM

13. LEUKOCYTES (WHITE BLOOD CELLS) HAVE NUCLEI WHICH CHANGE THE SHAPE OF THE CELLS MUCH SMALLER IN NUMBER (700 TO 1) USED FOR MEDICAL DIAGNOSIS DUE TO SIZE, SHAPE, AND APPEARANCE (MAIN METHOD) – NEUTROPHILS – LAVENDAR GRANULES (MOST NUMEROUS) – EOSINOPHILS – BRIGHT PINK GRANULES – BASOPHILS – DARK BLUE GRANULES – WHEN HAVING ALLERGIC REACTION THERE ARE MORE E & B.

14. LEUKOCYTES (CON’T) CERTAIN NEUTROPHILS INDICATE INFECTION FUNCTION IS TO DESTROY ANY PATHOGEN THAT ENTERS YOUR BODY LEUKOCYTES SURROUND PATHOGENS THROUGH PHAGOCYTOSIS AND CREATE PUS

15. THROMBOCYTES (PLATELETS) TINY STRUCTURES THAT ARE FRAGMENTS OF CELLS ESSENTIAL FOR BLOOD COAGULATION THEY STICK TOGETHER AND FORM A PLUG THAT SEALS A WOUND THEY ALSO RELEASE CHEMICALS THAT START A CLOT

16. LIFE SPAN ERYTHROCYTES – 120 DAYS LEUKOCYTES – 6 TO 8 HOURS IN BLOOD, LONGER IN ORGANS AND TISSUES THROMBOCYTES – 10 DAYS

17. HEMOSTASIS PROCESS THAT PREVENTS LOSS OF BLOOD AFTER AN INJURY – CONTRACTION OF SMOOTH MUSCLES IN THE BLOOD VESSEL WALL – PLATELET PLUG CREATED – FORMATION OF BLOOD CLOT READ ABOUT BLOOD CLOTTING

18. BLOOD TYPES HEMORRHAGE IS WHEN THERE IS EXCESSIVE BLEEDING DUE TO INJURY TRANSFUSION IS BLOOD ARTIFICALLY GIVEN TO A PATIENT WHEN BLOOD CELLS BREAK AND RELEASE CONTENTS, THAT IS CALLED HEMOLYSIS THERE ARE 4 TYPES OF BLOOD WHICH IS DETERMINED BY WHICH ANTIGEN (REACTS TO OTHER PROTEINS IN BLOOD) IS INVOLVED.

19. BLOOD TYPES SEE CHART ON PG 188 IN PURPLE BOOK

20. BLOOD TYPES (CON’T) IF HAVE A ANTIGEN, HAVE TYPE A BLOOD B ANTIGEN, TYPE B BLOOD AB ANTIGEN, HAVE AB BLOOD NO ANTIGENS AT ALL – TYPE O BLOOD O BLOOD CAN BE GIVEN TO ANYONE CANNOT GIVE BLOOD THAT THE BODY WILL NOT TAKE – CAN CAUSE DEATH THROUGH SEVERE ALLERGIC SHOCK – WHY BLOOD BANKS DO SO MUCH TESTING.

21. BLOOD TYPES HOW DO THEY TEST THE BLOOD? – USE BLOOD SERUM (CLEAR) CONTAINING ANTIBODIES TO THE A OR B ANTIGENS ON THE BLOOD CELLS – THESE ANTIBODIES REACT WHEN THEY COME INTO CONTACT WITH A BLOOD CELLS, B BLOOD CELLS, OR AB BLOOD CELLS – THEY DO NOT REACT TO O BLOOD CELLS AT ALL – SEE CHART PG 189 IN PURPLE BOOK

22. Rh FACTOR THIS IS AN ANTIGEN GROUP IN MOST PEOPLE THAT WAS NAMED FOR THE RHESUS MONKEY, AS IT WAS FIRST FOUND IN THE BLOOD OF THAT ANIMAL. ALSO CALLED THE D ANTIGEN IF HAVE D ANTIGEN, YOU ARE Rh POSITIVE IF DO NOT HAVE ANTIGEN, ARE Rh NEGATIVE CAN DESTROY OTHER BLOOD CELLS IN A TRANSFUSION

23. Rh FACTOR (CON’T) PROBLEM FOR PREGNANCIES, AS IF THE MOTHERS AND FATHERS BLOOD DO NOT AGREE, THE REACTION TO THE DIFFERENT CELLS MAY START TO DESTROY THE CHILD’S RED BLOOD CELLS WHILE IN THE WOMB OR IN EARLY CHILDHOOD HOSPITALS NOW GIVE Rho-GAM TO THE MOTHER DURING PREGNANCY AND AFTER DELIVERY TO CLEAR PRE-FORMED ANTIBODIES FROM THE BLOOD

24. Rh FACTOR

25. BLOOD STUDIES Please read on your own