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Ontology of Sensors: Some Examples from Biology

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Presentation on theme: "Ontology of Sensors: Some Examples from Biology"— Presentation transcript:

1 Ontology of Sensors: Some Examples from Biology
Barry Smith National Center for Ontological Research (NCOR) University at Buffalo

2 An Introduction to "Beyond Semantic Sensor Network Ontologies (SSNO)“
Gary Berg-Cross Ontology Summit 2015 Track B Internet of Things: Toward Smart Networked Systems and Societies 1

3 The Stimulus-Sensor-Observation Ontology
Design Pattern

4 Semantic Sensor Network Ontology:
Ontology Summit 2015: Internet of Things: Toward Smart Networked Systems and Societies Semantic Sensor Network Ontology: Past, Present, and Future Cory Henson Sr. Research Scientist Bosch Research and Technology Center

5 Semantic Sensor Network Ontology

6 RELATION TO TIME GRANULARITY CONTINUANT OCCURRENT INDEPENDENT DEPENDENT ORGAN AND ORGANISM Organism (NCBI Taxonomy) Anatomical Entity (FMA, CARO) Organ Function (FMP, CPRO) Phenotypic Quality (PaTO) Biological Process (GO) CELL AND CELLULAR COMPONENT Cell (CL) Cellular Component (FMA, GO) Cellular Function MOLECULE Molecule (ChEBI, SO, RnaO, PrO) Molecular Function Molecular Process Open Biological and Biomedical Ontologies (OBO) Foundry (

7 Extension Strategy + Modular Organization
top level mid-level domain level Basic Formal Ontology (BFO) Information Artifact Ontology (IAO) Ontology for Biomedical Investigations (OBI) Ontology for General Medical Science (OGMS) Anatomy Ontology (FMA*, CARO) Environment Ontology (EnvO) Infectious Disease Ontology (IDO*) Biological Process Ontology (GO*) Cell Ontology (CL) Cellular Component (FMA*, GO*) Phenotypic Quality Ontology (PaTO) Subcellular Anatomy Ontology (SAO) Sequence Ontology (SO*) Molecular Function (GO*) Protein Ontology (PRO*) * = dedicated NIH funding Extension Strategy + Modular Organization

8 Basic Formal Ontology (BFO)
top level mid-level (generic hub) domain level (spokes populating downwards) Basic Formal Ontology (BFO) Information Artifact Ontology(IAO) IAO-Science IAO-Intel IAO-Computing IAO-Biology IAO-Physics IAO-Intel-Navy IAO-Intel-Army IAO-Intel- AirForce IAO-Software EMO- Ontology * = dedicated NIH funding Each module built by downward population from its parent

9 Measuring the glucose concentration in blood

10 Ontology for Biomedical Investigations

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12 OBI: Overview Core terms

13 Ontology for General Medical Science,
OGMS Ontology for General Medical Science,

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15 Big Picture

16 Nociceptive System

17 Pain Ontology Pain Canonical Pain
PCI: Pain with concordant tissue damage Variant Pain PNT: Pain without tissue damage Neuropathic nociception PRP: Pain-related phenomenon without pain PBWP: Pain behavior without pain TWP: Tissue damage without pain

18 PRP: Pain-Related Phenomena Without Pain
Symptoms Signs Physical Basis Examples Canonical Pain PCT: Pain with concordant tissue damage Pain Manifestation of tissue damage Signals sent to nociceptive system Activation of emotion- generating brain centers, which can produce increased heart rate, blood pressure, galvanic skin response. Peripheral tissue damage Intact nociceptive system Primary sunburn Pain from strained muscle Pain from fracture Pulpitis Variant Pain PNT: pain without concordant tissue damage Manifestation of some disorder in the patient Patient reports of pain are either exaggerated or muted relative to disorder Activation of emotion generating brain centers Physical disorder of amplitude control mechanisms associated with the nociceptive system Intact nociceptive system Myofascial pain disorder Tension-type headache Chronic back pain NN: neuro- pathic nociception Neurological test confirming nerve damage Disorder in the nociceptive system Trigeminal neuralgia Post-herpetic neuralgia Diabetic neuropathy Central pain PRP: Pain-Related Phenomena Without Pain PBWP: pain behavior without pain Aaargh! Report of pain Sick role behaviors accompanied by normal clinical examination Grossly exaggerated pain behaviors Identified external incentives Mental states such as anxiety, rather than peripheral tissue locus Disordered emotional or cognitive systems misinterpreting sensory signals Factitious pain Malingering Anxiety-induced pain report TWP: tissue- damage without pain No pain Manifestation of tissue damage normally of the sort to cause pain Suppression of pain system by one or other mechanism Stress associated with sudden emergencies Physiological damping of the pain process caused by endorphins Placebo-induced opioid analgesia Genetic insensitivity to pain

19 The Pain Ontology as subtype of Sensing Ontology
Canonical sensing Canonical sensing with concordant signal Variant sensing Sensing with non-concordant signal Hallucinating (sensing but no signal) Sensing-related phenomena with no sensing Sensing report but no sensing Signal but no sensing

20 Four types of (pain) sensor failure
Canonical Pain PCI: Pain with concordant tissue damage Variant Pain PNT: Pain without tissue damage Neuropathic nociception PRP: Pain-related phenomenon without pain PBWP: Pain behavior without pain TWP: Tissue damage without pain triggered by design inputs not triggered by design inputs triggered without inputs generates ungrounded outputs triggered by self

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