1. 2002 ISHLT LUNG TRANSPLANTATION Overall

2. 2002 ISHLT NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND PROCEDURE TYPE 13 1547 80 185 408 686 902 1069 1204 13411337 1416 1413 1408 1508 1554 * Numbers may be low due to delayed reporting.

3. 2002 ISHLT NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND LOCATION * Numbers may be low due to delayed reporting.

4. 2002 ISHLT LUNG TRANSPLANTS: Donor Age by Year of Transplant

5. 2002 ISHLT AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS (1985-2001)

6. 2002 ISHLT AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS BY ERA 1985-19961997-2001

7. 2002 ISHLT LUNG TRANSPLANTATION Actuarial Survival (1990-2000) Double lung: 1/2-life = 4.9 Years; Conditional 1/2-life = 7.9 Years Single lung: 1/2-life = 3.7 Years; Conditional 1/2-life = 5.9 Years All lungs: 1/2-life = 4.1 Years; Conditional 1/2-life = 6.5 Years

8. 2002 ISHLT LUNG TRANSPLANTATION Adult Recipients

9. 2002 ISHLT ADULT LUNG TRANSPLANTATION: Indications (1995-2001) DIAGNOSISSLT (N = 4,663)BLT (N = 4,118)TOTAL (N = 8,781) COPD/Emphysema2,53654.4%92622.5%3,46239.4% IPF1,11023.8%3769.1%1,48616.9% CF521.1%1,36033.0%1,41216.1% Alpha-14088.7%4079.9%8159.3% PPH611.3%3408.3%4014.6% Sarcoidosis1262.7%1062.6%2322.6% Bronchiectasis140.3%1764.3%1902.2% Congenital Heart Disease80.2%952.3%1031.2% LAM420.9%531.3%951.1% Re-TX: OB440.9%431.0%871.0% OB (Non-ReTX)320.7%501.2%820.9% Re-TX: Non-OB330.7%360.9%690.8% Connective Tissue Disorder 200.4%180.4%380.4% Cancer70.2%280.7%350.4% Histiocytosis X110.2%8 190.2% Other1593.4%962.3%2552.9%

10. 2002 ISHLT ADULT LUNG TRANSPLANTATION: Indications (1995-2001) Single Lung Transplants Bilateral/Double Lung Transplants

11. 2002 ISHLT ADULT LUNG TRANSPLANTATION Indications By Year

12. 2002 ISHLT ADULT LUNG TRANSPLANTATION Actuarial Survival by Era (1988-2001) Survival comparisons by era 1988-1992 vs. 1993-1997: p = 0.007 1988-1992 vs. 1998-2001: p < 0.0001 1993-1997 vs. 1998-2001: p = 0.003

13. 2002 ISHLT ADULT LUNG TRANSPLANTATION Actuarial Survival by Age Group (1990-2001) Survival comparisons by age group 18-34 vs. 50-64: p < 0.0001 18-34 vs. 65+: p = 0.0009 35-49 vs. 50-64: p < 0.0001 35-49 vs. 65+: p = 0.0004

14. 2002 ISHLT ADULT LUNG TRANSPLANTATION Actuarial Survival By Diagnosis (1990-2001)

15. 2002 ISHLT ADULT LUNG TRANSPLANTATION Actuarial Survival By Procedure Type Diagnosis: Alpha-1 Antitrypsin Deficiency (1990-2001) P = 0.03

16. 2002 ISHLT ADULT LUNG TRANSPLANTATION Actuarial Survival by Procedure Type Diagnosis: Emphysema/COPD (1990-2001) P < 0.0001

17. 2002 ISHLT ADULT LUNG TRANSPLANTATION Actuarial Survival by Procedure Type Diagnosis: IPF (1990-2001) P = 0.2

18. 2002 ISHLT ADULT LUNG TRANSPLANTATION Actuarial Survival by Procedure Type Diagnosis: PPH (1990-2001) P = 0.4

19. 2002 ISHLT ADULT LUNG TRANSPLANTS (1996-2001) Risk Factors for 1 Year Mortality In Descending Order of Magnitude N=5,242

20. 2002 ISHLT ADULT LUNG TRANSPLANTS (1996-2001) Risk Factors for 1 Year Mortality In Descending Order of Magnitude N=5,242

21. 2002 ISHLT ADULT LUNG TRANSPLANTS (1996-2001) Risk Factors for 1 Year Mortality Continuous Factors N=5,242

22. 2002 ISHLT ADULT LUNG TRANSPLANTS (1996-2001) Risk Factors for 1 Year Mortality Continuous Factors N=5,242

23. 2002 ISHLT ADULT LUNG TRANSPLANTS (1996-2001) Risk Factors for 1 Year Mortality Continuous Factors N=5,242

24. 2002 ISHLT ADULT LUNG TRANSPLANTS (1996-2001) Factors Not Significant for 1 Year Mortality Steroid dependency Ischemia time % Predicted FeV1 % Predicted FVC Transfusions Diabetes Weight (donor) Height (donor) Donor clinical infection Donor history of hypertension Donor given steroids

25. 2002 ISHLT ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality In Descending Order of Magnitude N=3,098

26. 2002 ISHLT ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality In Descending Order of Magnitude N=3,098

27. 2002 ISHLT ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality Continuous Factors N=3,098

28. 2002 ISHLT ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality Continuous Factors N=3,098

29. 2002 ISHLT ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality Continuous Factors N=3,098

30. 2002 ISHLT ADULT LUNG TRANSPLANTS (April 1994-December 1996) Factors Not Significant for 5 Year Mortality Steroid dependency Ventilator Ischemia time % Predicted FeV1 % Predicted FVC Transfusions Diabetes Weight (donor) Height (donor) Donor clinical infection Donor history of hypertension Donor given steroids

31. 2002 ISHLT ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year In Descending Order of Magnitude N=2,285

32. 2002 ISHLT ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year Continuous Factors N=2,285

33. 2002 ISHLT ADULT LUNG RECIPIENTS Functional Status (April 1994 – December 2001)

34. 2002 ISHLT ADULT LUNG RECIPIENTS Employment Status (U.S.: April 1994 – December 2001)

35. 2002 ISHLT ADULT LUNG RECIPIENTS: Rehospitalization Post-transplant (April 1994 - December 2001)

36. 2002 ISHLT ADULT LUNG RECIPIENTS Induction Immunosuppression For follow-ups between October 1999 and December 2001

37. 2002 ISHLT ADULT LUNG RECIPIENTS Maintenance Immunosuppression At Any Time During Follow-up Period For follow-ups between October 1999 and December 2001

38. 2002 ISHLT ADULT LUNG RECIPIENTS Maintenance Immunosuppression At Time of Follow-up For follow-ups between October 1999 and December 2001

39. 2002 ISHLT ADULT LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001 1 Year Follow-up (N = 1,177)5 Year Follow-up (N = 547)

40. 2002 ISHLT ADULT LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001

41. 2002 ISHLT POST-LUNG TRANSPLANT MORBIDITY For Adult Recipients (April 1994-December 2001)

42. 2002 ISHLT Freedom from Bronchiolitis Obliterans For Adult Lung Recipients (April 1994-December 2000)

43. 2002 ISHLT Freedom from Renal Dysfunction* For Adult Lung Recipients (April 1994-December 2000) * Renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant

44. 2002 ISHLT MALIGNANCY POST-LUNG TRANSPLANTATION FOR ADULTS Cumulative Incidence for Survivors (April 1994-December 2001) Malignancy/Type1-Year Survivors5-Year Survivors No Malignancy4,583 (96.0%)731 (87.2%) Malignancy (all types combined)189 (4.0%)107 (12.8%) Malignancy Type Skin3754 Lymph9115 Other3921 Lymph + Skin3 Lymph + Other4 Skin + Other2 Type Not Reported228

45. 2002 ISHLT Freedom from Malignancy For Adult Lung Recipients (April 1994-December 2000)

46. 2002 ISHLT ADULT LUNG TRANSPLANT RECIPIENTS: Cause Of Death (1982-2001) 0-30 Days (N = 962) 31 Days - 1 Year (N = 1,230) >1 Year - 3 Years (N = 953) >3 Year - 5 Years (N = 479) CAD121.2%100.8%111.2%71.5% Cardiac899.3%443.5%202.1%153.1% Malignancy, Other00.0%241.9%394.1%387.9% Lymphoma10.1%403.2%232.4%81.7% CMV50.5%514.0%161.7%30.6% Acute Rejection575.9%554.4%202.1%40.8% Infection, Non-CMV23724.6%48438.3%23724.9%9018.8% Bronchiolitis70.7%755.9%28630.0%15833.0% Primary Graft Failure15816.4%755.9%555.8%194.0% Graft Failure - Other14114.7%14011.1%9710.2%6613.8% Technical858.8%383.0%90.9%10.2% Other17017.7%22718.0%14014.7%7014.6% Total962100.0%1263100.0%953100.0%479100.0%

47. 2002 ISHLT ADULT LUNG TRANSPLANT RECIPIENTS: Cause Of Death (1982-2001) Timing of Death

48. 2002 ISHLT ADULT LUNG TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in 0-30 Days Year of Transplant

49. 2002 ISHLT ADULT LUNG TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in 31 Days – 1 Year Year of Transplant

50. 2002 ISHLT ADULT LUNG TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in >1 Year – 3 Years Year of Transplant

51. 2002 ISHLT ADULT LUNG TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in >3 Years – 5 Years Year of Transplant

52. 2002 ISHLT ADULT LUNG TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in >5 Years Year of Transplant