1. Muscle Physiology Summer Prematriculation Program Summer 2004 Rahul Dave Rdave2@uic.edu (312) 996-7610 Rm 206 CMW

2. Muscles act in many organ systems

3. Muscles need a signal to contract

4. Muscle Anatomy

5. Motor Unit Nerve branch Muscle Main Nerve

6. Skeletal Muscle

7. Smooth Muscle

8. Cardiac Muscle 1

9. Cardiac Muscle 2 Intercalated Disc

10. 3 Fiber Types FuelATPFatigues? Fast WhiteGlycHighHard Fast RedOxidHighMedium Slow RedOxidLowEasy Motor Unit Size Recruitment Order Use Fast WhiteLargeThirdPower Lift Fast RedMediumSecondJogging Slow RedSmallFirstPostural mm

11. Z-disc H-zone M-line A-band I-band Sarcomere Structure

12. Sliding Filament Theory

13. BrownTropomyosin YellowTroponins BlueActin BlackMyosin Head Bind Site Other Muscle Proteins PinkMyosin

14. Smooth Muscle Structure

15. Muscle Structure Describe the hierarchy of organization in muscle Distinguish smooth, skeletal and cardiac muscle based on histology Understand and rationalize the differences between fiber types Know the skeletal muscle sarcomere structure cold.

16. Nerve- Muscle Interface

17. Excitation-Contraction Coupling

18. Cross Bridge Cycle

19. Smooth Muscle Nerve-Muscle Interface

20. E-C Coupling (Smooth) G Neurotransmitter SR IP3 PIP2 Ca 2+

21. Crossbridge Cycle (Smooth)

22. Muscle Contraction Know each step in transmission across the neuromuscular junction Know each step in E-C Coupling for striated muscle Know each step in the cross-bridge cycle for striated muscle Know the differences between smooth and striated (skeletal + cardiac) muscle

23. Preload and Afterload Preload The force (load) a muscle exerts prior to contraction. Pre-contraction Afterload Force muscle exerts during contraction. After [the start of] contraction Demonstration

24. Frank-Starling Law

25. Force-Velocity Curve

26. Exercise Physiology These are all adaptations Learning new motor patterns Strength exercises: muscle hypertrophy Endurance exercises: changes in muscle metabolism

27. Muscle Diseases Metabolism Lactic Acidosis Glycogen Storage Diseases Muscle Function Dilated Cardiomyopathy Muscular Dystrophy Malignant Hyperthermia Neurologic Hirschsprungs disease Myesthenia Gravis Multiple Sclerosis Parkinsons Disease Polio