1. Disorders associated with a positive test for Rheumatoid Factor
Autoimmune Disorders
RA, Primary Sjogrens, MCTD, PM/DM, Scleroderma, ANCA-Associated vasculitis, PAN, Primary Biliary Cirrhosis.
Chronic Infections
Subacture bacterial endocarditis, TB, Leprosy, Syphilis, Hep C, Hep B, Other viral infections, Parasitic Infections
Miscellaneous Conditions
Sarcoidosis, Idiopathic Pulm Fibrosis, Silicosis, Asbestosis, Malignancy, Age >65.
(from: CURRENT Rheumatology, Chapter 3: Laboratory Diagnosis. McGraw-Hill Companies ). Available at Himmelfarb’s Library Website.

2. Conditions Associated with positive ANA detected by Indirect Immunofluorescence
Rheumatic Disease
SLE, MCTD, Scleroderma, Sjogren, RA, PM/DM, Discoid Lupus.
Organ-Specific Autoimmune Disease
Autoimmune thryoid disease, autoimmune hepatitis, Primary biliary cirrhosis, Autoimmune cholangitis.
Other
Drug-induces lupus, asymptomatic drug-induced ANA, chronic infections, idiopathic pulmonary fibrosis, primary pulmonary hypertension, lymphoproliferative disorders.
(from: CURRENT Rheumatology, Chapter 3: Laboratory Diagnosis. McGraw-Hill Companies ). Available at Himmelfarb’s Library Website.

3. Selected Antinuclear Antibodies with High Sensitivity or Specificity
Conditions High Sensitivity High Specificity
SLE ANA Anti-dsDNA, Anti-Sm
Drug-Induced Lupus ANA, antihistone --
Neonatal Cutaneous Lupus Maternal anti-Ro/SS-A --
Congenital complete heart block Maternal anti-Ro/SS-A --
MCTD ANA, anti-RNP --
Primary Sjogren Anti-Ro/SS-A (75%) --
Scleroderma (limited and Difuse) ANA (>85%) Anticentromere, anti-Scl-70
High sensitivity: >95% except where noted. High specificity: >95% except where noted.
(from: CURRENT Rheumatology, Chapter 3: Laboratory Diagnosis. McGraw-Hill Companies ). Available at Himmelfarb’s Library Website.