1. Copyright 2010, John Wiley & Sons, Inc. Chapter 11 Autonomic Nervous System (ANS)

2. Copyright 2010, John Wiley & Sons, Inc. Comparison: SomaticNS vs AutonomicNS SNS  Controls skeletal muscle  Conscious, voluntary control  Motor pathway: one neuron from CNS to effector  Does include sensory neurons (from skin, skeletal muscles, and special sense organs)  All release the neurotransmitter ACh ANS  Controls viscera: smooth and cardiac muscle, and glands  Unconscious, involuntary  Motor pathway: series of two neurons from CNS to effector  Does include sensory neurons (monitors viscera)  Two divisions: sympathetic, parasympathetic  Release either ACh or NE

3. Copyright 2010, John Wiley & Sons, Inc. Somatic Nervous System

4. Copyright 2010, John Wiley & Sons, Inc. Introduction to the ANS Somatic nervous system (SNS) + ANS  peripheral nervous system (PNS) ANS  Is regulated by hypothalamus, brainstem The ANS supplies nerves to viscera  Smooth muscle (stomach, blood vessels)  Cardiac muscle (heart)  Glands (sweat and digestive glands)

5. Copyright 2010, John Wiley & Sons, Inc. ANS Motor Pathways Autonomic motor pathway includes two motor neurons  CNS  (Autonomic ganglion) Preganglionic  Postganglionic neuron  to effector

6. Copyright 2010, John Wiley & Sons, Inc. 11-61 Autonomic Nerve Fibers

7. Copyright 2010, John Wiley & Sons, Inc. 11-60 Two Divisions sympathetic – prepares body for fight or flight situations parasympathetic – prepares body for resting and digesting activities Autonomic Nervous System

8. Copyright 2010, John Wiley & Sons, Inc. Divisions of the ANS Sympathetic (S) + parasympathetic (P) Most viscera supplied with nerves of both S and P divisions: dual innervation S and P have opposite (antagonistic) effects  Heart rate: S stimulates, P inhibits  Digestive organs: S inhibit, P stimulate Some viscera receive only S (not P) nerves:  Sweat glands, many blood vessels, hair muscles

9. Copyright 2010, John Wiley & Sons, Inc. 11-70 Largely CNS 1. Medulla oblongata cardiac, vasomotor and respiratory activities 2.Hypothalamus regulates balance between sympathetic and parasympathetic activity visceral functions 3.Limbic system & cerebral cortex emotional responses Control of Autonomic Activity

10. Copyright 2010, John Wiley & Sons, Inc. ANS Motor Pathways

11. Copyright 2010, John Wiley & Sons, Inc. Sympathetic (S) Preganglionic Cell bodies located in lateral gray of spinal cord segments T1-T12 + L1-L2 called “thoracolumbar” Axons pass through ventral roots of spinal nerves May branch many times May ascend or descend (from cervical to sacral) Can synapse with 20 or more postganglionic cell bodies Results: widespread effects (viscera respond with one another)

12. Copyright 2010, John Wiley & Sons, Inc. 11-62 Sympathetic Division

13. Copyright 2010, John Wiley & Sons, Inc. Sympathetic (S) Postganglionic cell bodies located “Trunk ganglia”  2 long chains lateral to vertebrae “Prevertebral ganglia”  anterior to 3 large abdominal arteries

14. Copyright 2010, John Wiley & Sons, Inc. “Trunk ganglia” From cervical to sacral regions  widespread effects Many axons pass back into spinal nerves to reach skin  sweat glands, hair muscles, blood vessels

15. Copyright 2010, John Wiley & Sons, Inc. “Prevertebral ganglia” Named celiac, superior and inferior mesenteric ganglia  Supply abdominal viscera: stomach, intestine, kidneys, liver, spleen Axons pass from ganglia to viscera in S nerves

16. Copyright 2010, John Wiley & Sons, Inc. 11-63 Sympathetic Division

17. Copyright 2010, John Wiley & Sons, Inc. 11-64 Sympathetic Division

18. Copyright 2010, John Wiley & Sons, Inc. Parasympathetic (P) Preganglionic Cell bodies located in brainstem + in spinal cord segments S2-S4  “craniosacral”

19. Copyright 2010, John Wiley & Sons, Inc. Parasympathetic Preganglionic  Axons in cranial nerves III, VII, IX and X and in pelvic nerves from S2-S4 Vagus nerves (cranial nerves X) carry 80% of all P nerve impulses. Vagus nerves carry both motor and sensory neurons to/from viscera within the thorax and most of the abdominal cavity. axons do not branch or pass though S trunk ganglia but pass directly almost to viscera

20. Copyright 2010, John Wiley & Sons, Inc. 11-66 Parasympathetic Division

21. Copyright 2010, John Wiley & Sons, Inc. Parasympathetic (P) Postganglionic Cell bodies lie in terminal ganglia  Located within or near the innervated organ  cause precise, localized (not widespread) effects  S nerves supply all viscera but P nerves do not reach some sweat glands, arrector pili muscles, kidneys, spleen, adrenal medullae, and the walls of most blood vessels. Axons pass from ganglia to viscera in P nerves

22. Copyright 2010, John Wiley & Sons, Inc. Parasympathetic (P) Division

23. Copyright 2010, John Wiley & Sons, Inc. ANS Neurotransmitters: Comparison Acetylcholine (ACh) more common released by:  All S and P preganglionic axons  All P postganglionic axons  Some S postganglionic axons (to sweat glands) destroyed by enzyme ACh-ase short-lived response Norepinephrine (NE) less common released by:  Almost all S postganglionic axons longer lasting effects enhanced by epinephrine + NE from adrenal medullae

24. Copyright 2010, John Wiley & Sons, Inc. Sympathetic Effects Fight-or-flight activities  Increase heart rate and contraction, and blood pressure (BP)  Dilate pupils  Dilate airways  Dilate vessels to skeletal muscles, heart, liver and adipose tissue  Constrict blood vessels to nonessential organs: skin, GI tract, kidneys  Mobilize nutrients for energy: glucose and fats

25. Copyright 2010, John Wiley & Sons, Inc. Parasympathetic Effects Rest-and-digest activities  SLUDD Salivation Lacrimation Urination Digestion Defecation  Decrease heart rate, airway diameter, pupil diameter

26. Copyright 2010, John Wiley & Sons, Inc. End of Chapter 11 Copyright 2010 John Wiley & Sons, Inc. All rights reserved. Reproduction or translation of this work beyond that permitted in section 117 of the 1976 United States Copyright Act without express permission of the copyright owner is unlawful. Request for further information should be addressed to the Permission Department, John Wiley & Sons, Inc. The purchaser may make back-up copies for his/her own use only and not for distribution or resale. The Publishers assumes no responsibility for errors, omissions, or damages caused by the use of theses programs or from the use of the information herein.