1. Office of Research and Development Photo image area measures 1.5” H x 7” and can be masked by a collage strip of one, two or three images. The photo image area is located 3.19” from left and 3.81” from top of page. Each image used in collage should be reduced or cropped to a maximum of 1.5” high, stroked with a 1.5 pt white frame and positioned edge-to-edge with accompanying images. Framework for Rapid Prioritization Linda Sheldon, Ph.D. Associate Director, National Exposure Research Laboratory April 6, 2010

2. Office of Research and Development 1 The Challenge “Assure chemical safety in a rapidly changing world” Too many chemicals too little data –75,000 chemicals in TSCA inventory –500 – 1000 new chemicals each year Must modernize and strengthen the tools available for testing and prioritization –Based on hazard and exposure –Based on sound science –Must be transparent and understandable

3. Office of Research and Development 2 The Research Goal To develop innovative approaches, tools, and enhanced scientific understanding to rapidly and effectively prioritize chemicals for further safety testing based on exposure

4. Office of Research and Development 3 The Research Approach Develop a framework for chemical exposures Align current databases, data collection protocols, and prioritization tools within the framework Evaluate and compare existing prioritization tools ID crucial gaps in our knowledge, data, approaches, and tools Conduct scientific research to fill these gaps

5. Office of Research and Development 4 Framework Requirements Identify the chemicals and the scenarios associated with the highest exposures to categorize chemicals for further testing –Chemicals once created must go someplace –Evaluate release/exposures for chemicals across their life cycles –Account for physico-chemical properties and stability of Chemical/intermediates Environmental degradates Metabolites – for in vitro assays such as Tox Cast –Incorporate spatial scales –Give special consideration to susceptible populations, especially children

6. Office of Research and Development 5 Life Cycle Stages Recycle Disposal Product Use Product Formulation Chemical Transport Chemical Manufacture

7. Office of Research and Development 6 Chemical Manufacture Chemical Transportation Production/ Formulation (Product or Processing Aid) Workplace Exposure Environmental Release Environmental Disposal Air Water Incineration Recycling Sewage Treatment Production Phases PRODUCT USE SCENARIOS Food Human Exposure RELEASEFATE/TRANSPORTCONCENTRATIONACTIVITYEXPOSURE A C T I V I T I E S Land

8. Office of Research and Development 7 Based on: Uniform System for the Evaluation of Substances v.4.0, 2002 LOCAL ENVIRONMENT REGION COUNTRY background concentrations inflow concentrations GLOBAL exchange Incorporation of Spatial Scales-- Environmental Release

9. Office of Research and Development 8 Product Use Scenarios PRODUCT n PRODUCT … PRODUCT 8 PRODUCT 7 PRODUCT 6 PRODUCT 5 PRODUCT 4 PRODUCT 3 PRODUCT 2 PRODUCT 1 Release Transport Reaction CONSUMER USE Disposal Location Frequency Timing Population Market Share RELEASEFATE/TRANSPORTCONCENTRATIONACTIVITYEXPOSURE Water Outdoor Air Surface Dust Human Exposure A C T I V I T I E S Soil Indoor Air Food

10. Office of Research and Development 9 NEAR-FIELD Cleaning, Personal Care, Hobby products Near- and Mid Field Exposures

11. Office of Research and Development 10 Environmental Release Food Water Land Human Exposure Product Disposal Air RELEASE FATE / TRANSPORT CONCENTRATION ACTIVITY EXPOSURE A C T I V I T I E S Product Disposal

12. Office of Research and Development 11 PRODUCT n PRODUCT … PRODUCT 8 PRODUCT 7 PRODUCT 6 PRODUCT 5 PRODUCT 4 PRODUCT 3 PRODUCT 2 PRODUCT 1 Release Reaction Product Use Disposal Location Frequency Timing Population Market Share Water Outdoor Air Surface Dust A C T I V I T I E S Soil Indoor Air Food Chemical Manufacture Chemical Transportation Production/ Formulation Workplace Exposure Environmental Release Environmental Disposal Air Water Incineration Recycling Sewage Treatment Food A C T I V I T I E S Land Transport Human Exposure Environmental Release Food Water Land Human Exposure Product Disposal Air A C T I V I T I E S RELEASE FATE / TRANSPORT CONCENTRATION ACTIVITY EXPOSURE FRAMEWORK Intermediates Degradates Chemical

13. Office of Research and Development 12 Summary Framework is critical –Understand what we need, what we have, and identify gaps –Provides a basis for communications –Provides a systematic approach for developing and evaluating tools, databases, and protocols –Supports screening and higher tier models –Allows an evaluation of trade off – energy, land use, etc.