1. Chapter 3 Digestion, Absorption, and Transport

2. Digestion Digestion is the process of breaking down foods into nutrients to prepare for absorption while overcoming 7 challenges.

3. Digestion Anatomy of the Digestive Tract – The gastrointestinal (GI) tract is the flexible muscular tube from mouth to anus. The lumen is the inner space of the tract. –The mouth is the beginning of the digestive system. Digestion in the mouth involves mastication (chewing), the stimulation of taste buds, and swallowing. The epiglottis closes to prevent food from entering the pharynx. After swallowing the food is called a bolus. –The esophagus is the tube that leads the bolus to the stomach. There is a sphincter at the upper and lower (also known as the cardiac sphincter) ends of the esophagus.

4. Choking Food becomes lodged in the trachea. The larnyx cannot make sounds. The Heimlich maneuver may need to be used. Strategies –Small bites –Chew thoroughly. –Don’t talk or laugh with food in the mouth. –Don’t eat when breathing hard.

6. Digestion Anatomy of the Digestive Tract –The stomach adds juices and grinds the bolus to a semiliquid mass called chyme. The pyloric sphincter regulates the flow of partially digested food into the small intestine. –The small intestine receives digestive juices from the gallbladder and the pancreas. The three segments of the small intestine are the duodenum, the jejunum and the ileum. –The large intestine (colon) begins at the ileocecal valve and ends at the rectum and anus. The chyme passes by the opening of the appendix.

8. Digestion The Muscular Action of Digestion – under autonomic control –Peristalsis pushes the digestive contents along. –Stomach action involves circular, longitudinal, and diagonal muscles. –Segmentation is contractions by circular muscles that contract and squeeze contents to promote mixing with digestive juices. –Sphincter contractions open and close passageways. This prevents reflux and controls the passage of contents.

12. Heartburn and “Acid Indigestion” Gastroesophageal reflux is the backward flow of stomach contents into the esophagus. Antacids and acid controllers may help indigestion.

14. Heartburn and “Acid Indigestion” Strategies –Small meals –Liquids between meals –Sit up while eating. –Wait 1 hour after eating before lying down. –Wait 2 hours after eating before exercising. –Refrain from tight-fitting clothing. –Avoid bothersome foods. –Refrain from tobacco use. –Lose weight if overweight.

15. Digestion The Secretions of Digestion –Includes digestive enzymes that act as catalysts in hydrolysis reactions –Saliva from the salivary glands moistens foods –Gastric juice from the gastric glands includes hydrochloric acid. The goblet cells of the stomach wall secrete mucus to protect the walls of the stomach from the high acidity levels that are measured by pH units. –Pancreatic juice contains intestinal enzymes (carbohydrase, lipase, protease) and bicarbonate. –Bile is produced by the liver, stored in the gall bladder, and acts as an emulsifier to suspend fat.

18. Digestion The Final Stage –Energy-yielding nutrients are disassembled for absorption. –Vitamins, minerals and water can be absorbed. –Undigested residues, including some fibers, continue through the digestive tract and form stool. –Recycling of usable materials

20. Fig. 3-7, p. 78 Transverse colon Ascending colon Descending colon Sigmoid colon Anus Rectum Appendix Opening from small intestine to large intestine End of small intestine Stepped Art

22. Absorption The enormous surface area of the small intestine facilitates nutrient absorption. Nutrients can be absorbed through simple diffusion, facilitated diffusion, or active transport.

24. Fig. 3-9, p. 81 Carrier loads nutrient on outside of cell... Outside cell Cell membrane... and then releases it on inside of cell. Inside cell FACILITATED DIFFUSION Some nutrients (such as the water- soluble vitamins) are absorbed by facilitated diffusion. They need a specific carrier to transport them from one side of the cell membrane to the other. (Alternatively, facilitated diffusion may occur when the carrier changes the cell membrane in such a way that the nutrients can pass through.) ACTIVE TRANSPORT Some nutrients (such as glucose and amino acids) must be absorbed actively. These nutrients move against a concentration gradient, which requires energy. Stepped Art Some nutrients (such as water and small lipids) are absorbed by simple diffusion. They cross into intestinal cells freely. SIMPLE DIFFUSION

25. Absorption Anatomy of the Absorptive System –Villi are the fingerlike projections within the folds of the small intestine that move in a wave-like pattern to trap nutrients. –Microvilli are the microscopic hairlike projections on each villi. –Crypts are the tubular glands that lie between the intestinal villi. –Goblet cells are located between the villi and secrete a protective thick mucus.

27. Absorption A Closer Look at the Intestinal Cells –Specialization of the cells to absorb different nutrients –“Food combining” which emphasizes separating food for digestive purposes is a myth. –Preparing Nutrients for Transport Water-soluble nutrients and small products of fat digestion are released to the bloodstream. Fat-soluble vitamins and larger fats form chylomicrons and are released to the lymphatic system.

28. The Circulatory System Water-soluble nutrients and small fats are routed to the liver before being transported to the cells. Fat-soluble nutrients, entering from the lymph, bypass the liver at first and eventually enter the vascular system.

29. The Circulatory System The vascular system consists of arteries, capillaries and veins. –The hepatic portal vein directs blood from the GI tract to the liver. –The hepatic vein takes blood from the liver to the heart. –The liver protects against toxic substances.

32. The Circulatory System The lymphatic system consists of one-way vessels to transport fluid. –Lymph is a clear, yellowish fluid without red blood cells or platelets that moves through the body by muscle contractions. –The thoracic duct is the lymph’s route to the heart. –The subclavian vein provides a return of lymph to the vascular system. –Lacteals are the lymphatic vessels of the intestine that absorb nutrients and pass them to the lymphatic system.