1. Study flow diagram BB=blockers; HTN=hypertension; RCT=randomized controlled trial Bangalore S. et al. Am J Cardiol. 2007;100:1254-62

2. Clinical trials comparing ß-blockers with placebo or diuretics Bangalore S. et al. Am J Cardiol. 2007;100:1254-62

3. Blood pressure response: ß-blockers versus placebo or diuretics

4. Bangalore S. et al. Am J Cardiol. 2007;100:1254-62 Clinical trials comparing ß-blockers with nondiuretic antihypertensive agents

5. Bangalore S. et al. Am J Cardiol. 2007;100:1254-62 Blood pressure response: ß-blockers versus nondiuretic antihypertensive agents

6. Bangalore S. et al. Am J Cardiol. 2007;100:1254-62 Effect of ß-blockers on the risk for new-onset DM when compared to nondiuretic antihypertensive agents (CCBs, ACE inhibitors [ACEi], and ARBs)

7. Bangalore S. et al. Am J Cardiol. 2007;100:1254-62 Effect of different ß-blocker types on the risk for new-onset DM compared with other agents

8. Bangalore S. et al. Am J Cardiol. 2007;100:1254-62 Meta-regression analysis

9. Bangalore S. et al. Am J Cardiol. 2007;100:1254-62 RR for new-onset DM (NODM) as a function of systolic blood pressure (SBP) difference between ß-blockers and nondiuretic antihypertensive agents

10. Bangalore S. et al. Am J Cardiol. 2007;100:1254-62 RR for new-onset DM as a function of baseline fasting blood glucose levels

11. Bangalore S. et al. Am J Cardiol. 2007;100:1254-62 RR for new-onset DM as a function of baseline BMI

12. Bangalore S. et al. Am J Cardiol. 2007;100:1254-62 RR for new-onset DM as a function of length of follow-up

13. Bangalore S. et al. Am J Cardiol. 2007;100:1254-62 ß-blockers for primary hypertension: pathogenesis for increased risk. BP=blood pressure SM=smooth muscle