1. Structure and Function of Skeletal Muscle

2. Three Muscle Types Skeletal- striated Cardiac- striated, intercalated discs Smooth- not striated All muscle tissue exhibit: Responsiveness - The ability to receive and respond to a stimulus Conductivity – the ability of the impulse to travel along the plasma membrane of the muscle cell. Contractility - The ability to shorten Elasticity - The ability to recoil and resume original length

3. Skeletal Muscle Human body contains over 400 skeletal muscles 40-50% of total body weight Functions of skeletal muscle Force production for locomotion and breathing Force production for postural support Heat production during cold stress

4. The Neuromuscular Junction Site where motor neuron meets the muscle fiber Separated by gap called the neuromuscular cleft Motor end plate Pocket formed around motor neuron by sarcolemma Neurotransmitter is released from the motor neuron Causes an end-plate potential (EPP) Depolarization of muscle fiber Each axonal terminal forms a junction with a single muscle fiber (cell) Single neuron has several connections and thus stimulate several muscle fibers

5. Motor Unit Consist of one nerve fiber and all the muscle fibers it innervate Behaves as a single functional unit and contract as one

6. Behavior of the whole muscle Threshold – a minimal voltage necessary to produce a muscle contraction Muscle twitch – a single contraction of skeletal muscle. It is composed of latent, contraction and relaxation periods Latent period – the time between stimulation and the beginning of contraction Includes all time required for excitation, excitation-contraction coupling, and stretching of the series elastic components Refractory period – a phase after a twitch during which the muscle can not respond to another stimulus

8. Force Regulation in Muscle 2 ways to stimulate variable contraction strength of a muscle: Multiple motor unit summation - activate more motor units. Increased stimulus force Wave summation - stimulate a muscle at a higher rate of stimuli delivered to the muscle Second stimulus is administered before complete relaxation of muscle Treppe – a response to series of stimuli of the same strength given before the muscle completely relaxed Fatigue – results from a prolonged period of contraction. Muscle loose the ability to contract

9. An initial stimulation and resulting twitch all by itself. Then we have 2 stimuli in somewhat rapid succession. The 2 nd twitch has added on to the first. This is known as wave or temporal summation. It occurs because there is still calcium from the 1 st twitch in the sarcoplasm at the time of the 2 nd twitch.

10. Muscle Fatigue Physiological inability to contract Results primarily from a relative deficit of ATP.

11. Types of Contractions Contractions can be: Isometric Iso= same, metr=measure Isotonic Iso=same, ton=tension

12. Isotonic Contractions In isotonic contractions, the muscle changes in length (decreasing the angle of the joint) and moves the load ( Iso=same, ton=tension) The two types of isotonic contractions are: Concentric contractions – the muscle shortens and does work Eccentric contractions – the muscle contracts as it lengthens Example – someone pulls your arm straight while at the same time you try to keep the arm locked in one position.

13. Isometric Contractions Tension increases to the muscle’s capacity, but the muscle neither shortens nor lengthens (Iso= same, metr=measure); postural muscles Occurs if the load is greater than the tension the muscle is able to develop Example - carrying an object - your hands and arms would be opposing the gravity with equal force going upwards. Since your arms are neither raising or lowering, your biceps will be isometrically contracting.

14. Isotonic and Isometric Contractions