1. Training Residents in Genomics (TRIG) Working Group Update: March 2013 Richard L. Haspel, MD, PhD Director, Laboratory Medicine Residency Training Program Beth Israel Deaconess Medical Center Chair, TRIG Working Group

2. Coming to a clinic near you…

3. 69% 31% 9/2010; N=42 PRODS Genomics Survey: We Need Training! YES NO 91% want to teach their residents genomic medicine

4. Training Residents in Genomics (TRIG) Working Group Goal: Help ensure implementation of a genomics curriculum in every pathology residency program by July 2012 Revise the BIDMC curriculum and develop tools for national implementation Utilize outreach resources of participant organizations including meetings/courses/resident forums to promote curricula. Develop questions for the RISE.

5. July: Present objectives/lectures at APC/PRODS Annual Meeting September: Submit RISE questions/survey Conferences: ACLPS, ASCP, NSGC, NCHPEG, USCAP March: Present lectures at USCAP Annual Meeting June: Possible R25 grant funding, $300,000 per year for 5 years 20112012 TRIG on track for 2012! March: Genomics appears on RISE March: Objectives/ structure completed 2010 December: First conference call May: Publication of TRIG review in Personalized Medicine

6. http://www.pathologytraining.org/trig_lecture.htm

8. Cancer Education Grants Program (R25/PAR-08-120) Purpose: This Funding Opportunity Announcement (FOA), issued by the National Cancer Institute (NCI), encourages applications for the development of: – Innovative cancer education programs; and – Cancer research dissemination projects that can be completed within 5 years.

9. R25: Specific Aims 1)To develop a pathology resident genomic medicine curriculum, with a major focus on cancer care, as well as tools for national implementation. – The TRIG Working Group will collaborate with the ASCP Continuing Professional Development (CPD) team. – Both instructional guides and online education modules will be developed. 2)To evaluate the curriculum using a pre/post-test design at four pathology residency programs using validated assessment tools. – Assessment tools will be created to evaluate knowledge, communication skills and attitudes related to genomics. – The residency directors at the four sites are Dr. Richard Haspel, Dr. Karen Kaul, Dr. Debra Leonard and Dr. Henry Rinder. All are TRIG Working Group members and are key personnel on the grant.

10. R25: Specific Aims 3)To promote curriculum implementation using the resources of major national pathology organizations so that >90% of pathology residency programs nationwide have high- quality training in cancer genomics by the end of year 5. – Build on the current success of the TRIG Working Group in promoting genomics education through major pathology organizations. 4)To assess the degree of nationwide implementation and efficacy of curricula in genomic medicine using the pathology resident in-service exam (RISE). – This aspect of the grant will build on the current success of the TRIG Working Group in developing exam and survey questions for the RISE. 10/2012: Awarded $1.3 million over 5 years

11. Lectures and instructional guide completed, made available Year 2Year 3 Year 1 Online modules completed, deployed Year 4Year 5 Online modules tested at five residency programs Assessment tool completed Questions on RISE Cancer genomics training in >90% of US pathology residency programs, assessed by RISE Dissemination at conferences, Year 3: Begin “Train-the-Trainer” sessions Funding: A new TRIG timeline

12. Training Residents in Genomics (TRIG) Working Group

13. TRIG Still On Track New TRIG members – ACMG Representative: Madhuri Hedge, PhD – Andrew Beck, MD – John Pfeifer, MD, PhD – Iris Schrijver, MD, PhD 2013 RISE: survey and knowledge questions submitted Workshops/Courses at major meetings – ASCP Annual Meeting (9/2013): Day-long resident workshop – CAP Annual Meeting (10/2013): Half-day course – USCAP Annual Meeting (2014): Submitted for resident workshop – ACLPS Annual Meeting (2014): Possible train-the-trainer session Curriculum: – Survey-based review completed (11) – Day-long meeting today – Designing exercises related to annotation and report generation

14. TRIG: Continuing to Evolve Achieved several major goals – Lectures – Dissemination Presentations Abstracts Articles – RISE survey and knowledge questions The future: R25 funding – Resident workshops – Online modules – Design assessment tools – Evaluate curriculum Need your help to spread the word!

15. www.genomicmedicineinitiative.org http://www.pathologytraining.org/trig_lecture.htm Thanks! TRIG Working Group PRODS Council Suzanne Ziemnik, Eric Parks and the ASCP Mark Sobel, MD, PhD ICPI BIDMC Faculty and Residents – Jeffrey Saffitz, MD, PhD

16. Food for Thought As with the practice of medicine, the best hope for understanding the quality of current educational techniques and for evaluating proposed new approaches is by conducting and disseminating research based on sound principles. Robert M. Golub, MD JAMA. 2009;301(9):972