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I. Pavlik Mycobacterium tuberculosis in animal and human populations and bovine tuberculosis in human population in Central European countries during the.

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Presentation on theme: "I. Pavlik Mycobacterium tuberculosis in animal and human populations and bovine tuberculosis in human population in Central European countries during the."— Presentation transcript:

1 I. Pavlik Mycobacterium tuberculosis in animal and human populations and bovine tuberculosis in human population in Central European countries during the years 1990 to 1999 Veterinary Research Institute, Brno, Czech Republic

2 Mycobacterium tuberculosis complex: M. tuberculosis M. africanum M. bovis M. bovis BCG M. bovis subsp. caprae (M. caprae) M. canettii M. microti M. pinnipedi Dvorska et al., Vet. Med.-Czech, 46, 2001, 309-328. http://www.vri.cz/docs/vetmed/46-12-309.pdf http://www.vri.cz/docs/vetmed/46-12-309.pdf

3 M. tuberculosis H37Rv M.africanum M. tuberculosis Manila genotype M. tuberculosis Beijing genotype M. bovis BCG M. bovis M. bovis subsp. caprae M. tuberculosis seal genotype M. microti type vole M. microti type Ilama M. canetti M. bovis Spoligotypes of members of M. tuberculosis complex Dvorska et al., Vet. Med.-Czech, 46, 2001, 309-328. http://www.vri.cz/docs/vetmed/46-12-309.pdf http://www.vri.cz/docs/vetmed/46-12-309.pdf

4 Pavlik et al., Vet. Med. Czech, 2002, 45-51. http://www.vri.cz/docs/vetmed/47-3-45.pdf http://www.vri.cz/docs/vetmed/47-3-45.pdf

5 Pavlik et al., Vet. Med. Czech, 2002, 45-51. http://www.vri.cz/docs/vetmed/47-3-45.pdf http://www.vri.cz/docs/vetmed/47-3-45.pdf

6 (10.3 mil.) Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf http://www.vri.cz/docs/vetmed/48-4-90.pdf

7 Pavlik et al., Vet. Med. Czech, 2003, 90-98. (5.4 mil.) Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf http://www.vri.cz/docs/vetmed/48-4-90.pdf

8 Pavlik et al., Vet. Med. Czech, 2003, 90-98. (4.5 mil.) Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf http://www.vri.cz/docs/vetmed/48-4-90.pdf

9 Pavlik et al., Vet. Med. Czech, 2003, 90-98. (2.0 mil.) Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf http://www.vri.cz/docs/vetmed/48-4-90.pdf

10 Pavlik et al., Vet. Med. Czech, 2003, 90-98. Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf http://www.vri.cz/docs/vetmed/48-4-90.pdf

11 Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf http://www.vri.cz/docs/vetmed/48-4-90.pdf

12 M. tuberculosis v tuberculous lesions in pigs Norway 1970-1975: 3 004/+ 3 (0.1%), Flesja et al., 1978 England 1953-1968: 626/+67 (10.7%), Lesslie and Birn, 1970 USA 1973-1977: 2 036/+ 1 (0.01%), Thoen et al., 1981 BRD 1961-1970: 2 055/+ 10 (0.49%), Schliesser, 1976 Slovakia 1972: 1 421/+ 1 (0.07%), Popluhar et al.,1974 Total: 9 142/+ 82 (0.90%) Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf http://www.vri.cz/docs/vetmed/48-4-83.pdf Cited references see in paper:

13 M. tuberculosis v tuberculous lesions in cattle BRD 1961-1970: 1 135/ + 2 (0.20%) Schliesser, 1976 Slovakia 1970: 553/ + 1 (0.18%) Popluhar et al., 1970 England 1953-1968: 14 439/ +13 (0.09%) Lesslie and Birn, 1970 USA 1973-1977: 7 007/ + 1 (0.01%) Thoen et al. 1981 Total: 23 134/ +82 (0.90%) Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf http://www.vri.cz/docs/vetmed/48-4-83.pdf Cited references see in paper:

14 M. tuberculosis v tuberculous lesions in wild animals USA: 29 (6.1%) from 474 nonhuman primates and wild ruminants (Thoen et al., 1981). Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf http://www.vri.cz/docs/vetmed/48-4-83.pdf Cited reference see in paper:

15 Sources of infection for animals Old visitors Purchased infected animals

16 13 17 1990-199913 Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf http://www.vri.cz/docs/vetmed/48-4-83.pdf

17 Animals in zoological garden Gdansk in Poland infected with M. tuberculosis (1990-1999) African elephant (Loxodonta africana)11997 Agouti (Dasyprocta aguti)11997 Tapir (Tapirus terrestris)11999 Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf http://www.vri.cz/docs/vetmed/48-4-83.pdf

18 Sources of infection for animals Infected man excreting causal agent of human tuberculosis by: sputum, less often urine, or faeces. (Thoen and Steele, 1995; Grange, 1996). Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf http://www.vri.cz/docs/vetmed/48-4-83.pdf Cited references see in paper:

19 External environment – source of infection? In Slovakia M. tuberculosis was isolated from river water with waste water from tuberculosis hospital (Laktis et al., 1970). Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf http://www.vri.cz/docs/vetmed/48-4-83.pdf Cited reference see in paper:

20 Thank you for your attention


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