1. BRCA2 Clark Cunningham March 26, 2015 BIOL445 American Cancer Society, http://www.cancer.org/involved/participate/makingstridesagainstbr eastcancer/make-a-pink-ribbon-lapel-pin, Science 13 September 2002: Vol. 297 no. 5588 pp. 1837-1848

2. BRCA2 mutations increase risk of breast and ovarian cancers BRCA1 and BRCA2: Cancer Risk and Genetic Testing, National Cancer Institute, Reviewed: January 22, 2014 http://www.cancer.gov/cancertopics/genetics/brca-fact-sheet

3. BRCA2 functions in double strand break repair BRCA2 acts here Cabimer Andalusian center for molecular biology and regenerative medicine, http://www.cabimer.es/web/en/dept/ctrm/dna- double-strand-break-repair-and-human-disease/, Accessed 3.25.15

4. BRCA2 is necessary for homology-directed repair Oxford University Press, http://carcin.oxfordjournals.org/content /31/6/961/F1.expansion.html

5. BRCA2 loads RAD51 onto DNA Nat Struct Mol Biol. 2010 October ; 17(10): 1260–1262.

6. BRCA2 sequence supports DNA and RAD51 binding, nuclear localization Carcinogenesis vol.31 no.6 pp.961–967, 2010 Human BRCA2 is found on the long arm of chromosome 13 and encodes 10,254 base pair of cDNA, 27 exons, and 3418 amino acids.

7. BRC repeats are key to BRCA2 function Oncogene (2006) 25, 5864–5874

8. Double strand break repair is nonconservative in BRCA2 mutants Carcinogenesis vol.31 no.6 pp.961–967, 2010 BRCA2 deficient V-C8 cells show increased total recombination and upregulated SSA, resulting in deletions of genetic material.

9. BRCA2 mutants show genomic instability, embryonic lethality, and radiation sensitivity Molecular Cell, Vol. 1, 347–357, February, 1998,

10. Estrogen-induced breast epithelial proliferation suggests mechanism for BRCA2 tumorigenesis Human Molecular Genetics, 2001, Vol. 10, No. 7, pp705-713

11. Treatment of BRCA2 mutant cancers with synthetic lethality Elizabeth A. Comen and Mark Robson, Inhibition of Poly(ADP)-Ribose Polymerase as a Therapeutic Strategy for Breast Cancer, Oncology, January 15, 2010 Karen Honey, FDA Approvals Bring New Hope for Patients With BRCA-mutant Ovarian Cancer, January 6, 2015, http://blog.aacr.org/fda-approval-olaparib/ PARP Inhibitor Olaparib

12. References H. Yang et al., BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure, Science 13 September 2002: Vol. 297 no. 5588 pp. 1837- 1848 American Cancer Society, http://www.cancer.org/involved/participate/makingstridesagainstbreastcancer/make-a-pink-ribbon-lapel-pin, Accessed 3.25.15 BRCA1 and BRCA2: Cancer Risk and Genetic Testing, National Cancer Institute, Reviewed: January 22, 2014 http://www.cancer.gov/cancertopics/genetics/brca-fact- sheet Cabimer Andalusian center for molecular biology and regenerative medicine, http://www.cabimer.es/web/en/dept/ctrm/dna-double-strand-break-repair-and- human-disease/, Accessed 3.25.15 Defais et al., Deficiency in BRCA2 leads to increase in non-conservative homologous recombination, Carcinogenesis vol.31 no.6 pp.961–967, 2010 BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair, Oxford University Press, http://carcin.oxfordjournals.org/content/31/6/961/F1.expansion.html, 2015 Heyer et al., Human BRCA2 protein promotes RAD51 filament formation on RPA-covered ssDNA, Nat Struct Mol Biol. 2010 October ; 17(10): 1260–1262. K Gudmundsdottir and A Ashworth, The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability, Carcinogenesis vol.31 no.6 pp.961–967, 2010 Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2, Bradley et al., Molecular Cell, Vol. 1, 347–357, February, 1998 Piri L. Welsch and Mary-Claire King, BRCA1 and BRCA2 and the genetics of breast and ovarian cancer, Human Molecular Genetics, Vol. 10, No. 7, pp705-713, 2001 Elizabeth A. Comen and Mark Robson, Inhibition of Poly(ADP)-Ribose Polymerase as a Therapeutic Strategy for Breast Cancer, Oncology, January 15, 2010 Karen Honey, FDA Approvals Bring New Hope for Patients With BRCA-mutant Ovarian Cancer, January 6, 2015, http://blog.aacr.org/fda-approval-olaparib/