1. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Slicer Workflow Engine: Aim Supplement 3D Slicer with Workflow Management System. Provide integration and interoperability between 3D Slicer and NA-MIC supported products – XNAT (structured image repository) and Grid Wizard Enterprise (high performance computing system), as well as non-Slicer image processing tools Implement it as within currently developed Structural Planning and Implementation in Neurological Exploration (SPINE) System. Workflow Management System for Image Processing Orchestrates automated and human activities required to complete an image processing experiment Supports short and long running processes. Tracks all activities. Provides standard and scalable solutions for Research and Clinical Trials

2. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Slicer Workflow Engine: Progress to date  Implemented Workflow Scenarios (Since Feb 2010)  Manual Lesion Segmentation with automated MRI image preprocessing steps and semi-automated brain anatomy segmentation steps. Practical use: MS Studies  PET/CT Image Processing for Longitudinal Biomarkers Analysis of Physiological Brain Activity. Practical use: chemotherapy follow-up, TBI assessment and follow-up  Preprocessing of MRI images for brain atrophy analysis with EM Segmentation. Practical use: Aging, HIV, TBI longitudinal studies, MS longitudinal studies  Integrated Novel Slicer Modules into Workflows  BRAINSFit, BRAINSResample for registration  N4ITK MRI Biasfield Correction for preprocessing  ComputeSUVBodyWiegh for PET scans biomarkers analysis  ROI and Volume Cropping for human activity steps

3. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Slicer Workflow Engine: Progress to date (Continued)  Created Workflow Rich Client GUI Modules  Data Organizing and Processing Status Monitoring  Computation Pipelines Launching  Human Activity Support:  Image and Reconstruction Data Exchange with Xnat Repository  User Friendly Modules for Deploying and Upgrading Workflow Services on Application Server  Two Deployment Scenarios  Processing on Local Workstations (larger end user pool, easier to install and support)  Server Side / Computational Cluster Processing (higher performance)  Workflow Clients Porting into Slicer4 (Prototype)  Slicer4 QT Widget Displaying Available Workflows. Part of Slicer4 Wizards Library  Deploying of Workflow GUIs as Slicer4 Thin Client (or Slicelet)  Distribution of Workflow GUIs with Slicer

4. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Slicer Workflow Engine: Progress to date (Continued) Research Projects Utilizing Slicer WF and SOA Solutions -EM Segmentation (Slicer3 / Slicer2’s Segmenter Module): -Social Cognition Study for MS Patients. PECS University, Hungary (Completed) -EM Segmentation (Slicer3): -Brain Atrophy Study for Aging Patient. Jewish Hospital/ BWH (In progress) -Brain Atrophy Study for HIV Patients. National HIV Consortium (In progress) -Traumatic Brain Injury. Dept. of Defense (Under evaluation) -Brain Atrophy for Pediatric MS Patients. MGH/BWH (Currently Testing) -PET/CT Biomarker Activity Assessment Workflow: -Post-chemotherapy follow-up. BWH (In progress) -Tractography : -DTI Image processing. Psychiatry Neuroimaging Lab/BWH (Under Evaluation)

5. Neuroimage Analysis Center http://nac.spl.harvard.edu An NCRR National Resource Center Slicer Workflow Engine: Conclusion Plan 2011 Migrate existing WF Clients into the Slicer4 Wizards Collection as QT Slicelets Build and distribute new WF Wizards as QT Modules as part of Slicer4 distribution Utilize QT technology advantage by making QT WF Wizards compatible with Slicer3 as Stand-Alone clients QT Widgets and Services for Xnat browsing and Project Organizing New Workflows to be added Automated EM Segmentation Workflows: Brain Anatomy, MS Lesions, WM Hyperintensity Universal multi-modal image registration suite for longitudinal studies. User-driven registration planning and preview scenarios Upgraded PET/CT biomarker activity pipeline: MRI Images registration and automated segmentation, incorporation of various methods of SUV computations Pediatric MS Image Processing