1. It is time to stop ignoring male fertility Gedis Grudzinskas UK www.grudzinskas.co.uk

2. Are these sperm all normal ?

3. Origins of DNA damage in the spermatozoa Externally or internally produced reactive oxygen species Aitken 2004, Kelton Tremellen, 2008 Default in apoptosis process

4. It is time to stop ignoring male fertility

5. Sterility as a social problem How has the modern woman responded to the liberties afforded by choice in our progressive societies? They have done so by becoming engaged fully in the workplace, become a more potent force in commerce and government but also delayed age at marriage, pregnancy and motherhood.

6. Supported by grants from UMCG and ZonMW, the Netherlands

7. Modified natural cycle IVF Natural cycle IVF

8. Modified natural cycle IVF

9. It is time to stop ignoring male fertility Fewer oocytes: Minimal stimulation/natural cycle IVF Delayed age at pregnancy and motherhood.

10. It is time to stop ignoring male fertility Fewer oocytes: Failed fertilisation Embryonic arrest No implantation Repeated IVF failure

11. It is time to stop ignoring male fertility

12. Are these sperm all normal ?

13. It is time to stop ignoring male fertility 2007

14. It is time to stop ignoring male fertility 1)Life style 2) Trauma 3) Preventative maintenance: anti-oxidants 4)Counselling 5)AOB

15. It is time to stop ignoring male fertility Life style Weight Cigarettes Alcohol Drugs

16. Origins of DNA damage in the spermatozoa Externally or internally produced reactive oxygen species Aitken 2004, Kelton Tremellen, 2008 Default in apoptosis process

17. It is time to stop ignoring male fertility Trauma Sauna Bicycle riding

18. It is time to stop ignoring male fertility 1) Preventative maintenance: anti-oxidants

19. It is time to stop ignoring male fertility Counselling http://www.mensfe.net/

20. It is time to stop ignoring male fertility

21. Society and advances in ART Solution is not more women in government or elsewhere behaving like men !!!!!! Changing behaviour of men after 7 years of age is not possible Change attitudes in society ? How

22. It is time to stop ignoring male fertility 2010

24. It is time to stop ignoring male fertility 1)AOB

25. It is time to stop ignoring male fertility Gedis Grudzinskas UK www.grudzinskas.co.uk