1. Living without Pain DE-KA TITAN ® – The intelligent Pain Reliever 1 Manfred Lehnert www.dekamed.com 3.11.2008

2. 2 www.dekamed.com 3.11.2008 The pain  Pain influences the quality of life  Pain conditions are one of the most frequent and burdensome forms of sickness  DeKa-Titan ® - Pain Reliever can be used to treat all types of pain  T he stronger the pain, the higher the effect of DeKa-Titan ® - Pain Reliever

3. 3 Manfred Lehnert www.dekamed.com 3.11.2008 Function of DeKa-Titan  Pain is transmitted by an electrical Signal, which is called Action Potential.  This signal is sent by Axon to brain in order to transform or translate the pain level. Basic information on pain transmission (I)

4. 4 Manfred Lehnert www.dekamed.com 3.11.2008 Function of DeKa-Titan  Excitable cells, noziceptors possess a rest potential.  The interior of an excitable cell in the rest state is at a negative potential between -60 to -100 mV to the external surface of the Axon tissue. This is caused by the different distribution of the ions in the two spaces. Basic information on pain transmission (II)

5. 5 Manfred Lehnert www.dekamed.com 3.11.2008 Function of DeKa-Titan  A stimulus causes an exceeded threshold potential. Induced by a by a briefly (< 1 ms) opening of the membrane channals for the small sodium ions. The membrane potential suddenly reduces, the nerve interior even becomes temporarily positive. Basic information on pain transmission (III)

6. 6 Manfred Lehnert www.dekamed.com 3.11.2008 Function of DeKa-Titan  After this „Relaxation-Time“ for repolarisation the cell has reached its ground potential (-60 to –100 mV) and a subsequent process begins again  The stimulus process of a receptor cell (noziceptor) centralized: Basic information on pain transmission (IV) rest potential activated potential Potential Difference Process- and Repolarisation time

7. 7 Manfred Lehnert www.dekamed.com 3.11.2008 Function of DeKa-Titan  The nerve fibre is excitable at the earleast after 2 ms. So the pain stimulus is transmitted by potential waves.  The maximum frequency action potentials can be triggered and conducted over the nerve fibres is 500 1/s. Basic information on pain transmission (V)

8.  The calculated maximum possible frequency at which action potentials can be triggered of 500 1/s does not comply with realistic in vivo-systems. Explanation  In addition to the upstream pain-initiating system, a downstream pain- inhibiting system exists, whose fibres originate from various levels of the central nervous system and which regulates the flow of noziceptive stimuli.  As the upstream pulse current is controlled by the pain-inhibiting system – like passing through a gate, this is also referred to as the gate control theory. Endorphines and enkephalines have been identified as physiological activators of the pain-inhibiting system. 8 Manfred Lehnert www.dekamed.com 3.11.2008 Function of DeKa-Titan Gate control theory

9.  Pharmaceutical products use the downstream pain-inhibiting system of the Gate Control Theory (Endorphines and enkephalines as physiological activators).  The pulsating DC voltage from this system can be measured in the peripheral nerve lines externally, i.e. through the skin and tissue.  DeKa-Titan ® - Pain Reliever uses the upstream pain-initiating system.  Like a RC element in an electrical circuit, a special capacitor circuit of DeKa- Titan ® - Pain Reliever placed on the skin makes it possible to smoothen the potential differences leading to an attenuation of the signal current of pain to the brain by nerves.  Thus a reduced level or no pain at all are reported to the brain. 9 Manfred Lehnert www.dekamed.com 3.11.2008 Function of DeKa-Titan The Idea

10. 10 Manfred Lehnert www.dekamed.com 3.11.2008  The DE-KA Titan Pain Reliever is basically suitable for handling any kind of pain. A definite pain pulse is important for stimulating the Pain Reliever.  Good results have been achieved especially for: Headache, migraine, trigeminal neuralgia, painful joints, tennis elbow, sciatica and back pain, general muscle pain and muscle cramp, rheumatism, post- operative pain and weather sensitivity. Application DeKa-Titan ® - Pain Reliever

11.  Scientific tests conducted by recognized and neutral institutions proved the effectiveness of the DE-KA Titan.  Tests conducted by a German University Result: Significant reduction of pain duration  Pain Clinic Just placing the sensor housing against the forearm veins produced a test success rate of of 54 % after only 30 minutes  Chang An Hospital, Xian Test period 2 months; 75% of the patients have experienced pain relief  Own experiences with patients led to a success rate of over 80% 11 Manfred Lehnert www.dekamed.com 3.11.2008 DeKa-Titan ® - Pain Reliever Medical Test

12. 12 Manfred Lehnert www.dekamed.com 3.11.2008  The DE-KA Titan is usually worn on the left wrist with the flat side of the housing in contact with the inside of the wrist. The wriststrap should not be too loose.  For severe pain in the lower extremities, it is advisable to attach an adhesive electrode in the area of the lumbar vertebrae, and for severe back pain or general pain an electrode should be attached as an alternative to the uppermost cervical vertebra. Way of usage DeKa-Titan ® - Pain Reliever

13. 13 Manfred Lehnert www.dekamed.com 3.11.2008 Suitable for immediate use – anytime, anywhere  Suitable for immediate use – anytime, anywhere  Needs no power supply  Small and handy – European Design  Effective  Without side effects  Simple to use  Worn like a wristwatch  Direct, discret connection to position of pain via electrodes  Low cost  No battery, no power supply  100 % - made in Germany Advantages DeKa-Titan ® - Pain Reliever

14. 14 Manfred Lehnert www.dekamed.com 3.11.2008 Patents DeKa-Titan ® - Pain Reliever Germany / EUUSA

15. 15 Manfred Lehnert www.dekamed.com 3.11.2008 Certificates DeKa-Titan ® - Pain Reliever USAEUEgyptAustralia

16. 16 Manfred Lehnert www.dekamed.com 3.11.2008 Patient feedback DeKa-Titan ® - Pain Reliever Nuremberg, 29.5.2008 Report on my Experience with the DE-KA-Titanium Bracelet I am happy to report on my positive experience with the DE-KA-titanium bracelet. After the birth of my 2nd son in 1987, I started suffering from migraines. The attacks were initially hormone-induced and cycle-dependent. The hormonal therapies available at the time were, however, successful only in the beginning, as the syndrome became independent and was no longer cycle-dependent. Accordingly, starting menopause did not bring any advantages for me, and the strong headaches teamed up with an ever increasing nausea. My husband is an established gynaecologist in a big practice, I myself am a member of a private medical aid insurance, which is certainly a favourable opportunity to make all therapeutic possibilities accessible to me. Helene Schaudig (I)

17. 17 Manfred Lehnert www.dekamed.com 3.11.2008 Patient feedback DeKa-Titan ® - Pain Reliever Everything imaginable had been tried, including all and any orthodox-medicine therapies of a medicine-based nature, relaxation exercises and psychotherapy. Alternative medicine, naturopathy, acupuncture and homeopathy were, of course, given a go too. None of the methods was successful. It must be said that the continuous intake of anti-depressants and whenever necessary, the additional dose of strong pain killers brought about a certain partial success. I, however, had to discontinue this treatment, as my personal effectiveness in my manifold tasks was no longer given: I felt as if I had been wrapped in cotton wool and my natural mental alertness was totally suppressed. In February 2008, I was introduced to the so-called “pain bracelet”, i.e. DE-KA-Titan. At first I was taken aback by the success and of course I was very happy. As recommended, I put on the titanium bracelet at the beginning of a migraine attack, connected it through cables with the correctly placed electrodes and went about my normal activities. To my absolute delight, up to 90 to 100 percent of the pain was no longer perceived. I did not have to take any pain killers. In many cases, when the additional feeling of nausea was not totally gone, I took a simple Vomex A suppository. Apart from the truly gained quality of life, I thought it was wonderful that I did not suffer any interference or reduction whatsoever in my effectiveness. My success prompted my husband to introduce the titanium bracelet to his patients now. Helene Schaudig (II)

18. 18 Manfred Lehnert www.dekamed.com 3.11.2008 Contact information DeKa-Titan ® - Pain Reliever Germany DE-KA Medizinprodukte GmbH & Co. KG Buchenschlag 85 D-90469 Nürnberg Hong Kong DE – KA Titan Medical (Asia) HK Ltd. Flat A, 1/F 155c Tong Fuk Village Lantau Island Tel. +852 2980 4914 Web-Site www.dekamed.de Telefon + 49 911 / 48 68 46 Mobil + 49 172 / 4 62 90 27 E-mail info@dekamed.com Ukraine Representative office: DE –KA Titan Medizinprodukte Gmbh & CO., KG in Ukraine, Kiev 38-B, Heroyev Dnipra Street, App. 38 Kiev, Ukraine Anya Slipenchuk ( Managing Director ) Tel: + 380 (50) 4465549 E-Mail:slipenchuk@dekamed.com

19. Thank you for your attention! DeKa-Titan ® The intelligent Pain Reliever Manfred Lehnert www.dekamed.com 3.11.2008