1. 1SpineMatrix

2. Product 2 SMI has developed the Lumbar Matrix System A unique spinal physiology imaging scan used to diagnose disc, facet and chronic LBP pathology SMI is the only company that offers this technology 10 issued US Patents (1 pending) 5 issued foreign patents (1 pending) FDA approved UL approved 4 functional CPT reimbursement codes 10 peer-reviewed published clinical papers SpineMatrix

4. We manufacture our own arrays We will begin manufacturing our hardware/software systems in July Control of vendors and W.I.P., provides as-needed inventory management Adds significant value to the company 4 SpineMatrix

5. Stage of Company Launched the LMS System in February 5 SpineMatrix

6. Customers Neuro and orthopaedic spine surgeons LMS usage cascade of treatment (when and how) 6 SpineMatrix

7. Creation of Company Technology Founder - Mark Finneran, MD Wooster, Ohio Trained neurosurgeon / rehabilitation physician who saw the need 30-40% of L.B. spine surgeries result in “failed back syndrome” Clearly points to the need for improved diagnostic and better defined treatment pathways 7 SpineMatrix

8. Market Demand Large, strong market demographics 21 million LBP hospital visits per year $145 billion spent annually on LBP patients resulting in 1.5 million spinal surgeries 60-65% success rate 8 SpineMatrix

9. Entrepreneur/CEO Market Exposure Twenty-Five Years experience in the ortho/spine marketplace Theken Spine – President Wright Medical Spine, Trauma, Biologics, Sr. VP Medtronic Sofamore Danek, VP 9 SpineMatrix

10. Financing Series A ($9.5 MM) NationWide Insurance (OH) ABL Group (OH) Z2 Ventures (OH) X-Gen (OH) Ohio Innovation Fund (OH) Dan Kellogg (OH) Series B ($8 MM) Psilos Group (NYC) (lead) ODOD (OH) ABL Group (OH) *Follow-on is available 10 SpineMatrix

11. Original Business Plan To outsource development and manufacturing Launch in the rehabilitation/workers’ comp. markets Utilize Independent distribution network 11 SpineMatrix

12. Revised Business Plan In-house manufacturing control Target neuro/ortho spine surgeons Utilize published and defined clinical support data Direct sales organization 12 SpineMatrix

13. Future Large Market Advantage-current cost savings environment for medical procedures Need for outcome-focused reproducible results No current competition for LMS System 13 SpineMatrix

14. Impact Of NE Ohio On Company Governor Strickland, Lt. Governor Fisher and ODOD – very supportive Akron Mayor Donald Plusquellic and his staff – very supportive BioEnterprise Interaction 14 SpineMatrix

15. Challenges Recruiting at the Sr. Management level Medical device vendors and contract Manufacturing base to service small companies Overall economic trends in the Akron region Lack of larger (lead) VC firms in Ohio that focus on medical devices and have significant follow-on capacity 15 SpineMatrix

16. Lessons Learned / Business Plan Never assume that previous device development and manufacturing data has value Adoption curve for something brand new Issues with third-party payers 16 SpineMatrix