1. Schwamm et al. Circulation. 2010 epub April 6Schwamm et al. Race/Ethnicity, Quality of Care, and Outcomes in Ischemic Stroke Lee H. Schwamm, MD; Mathew J. Reeves, PhD; Wenqin Pan, PhD; Eric E. Smith, MD, MPH; Michael R. Frankel, MD; DaiWai Olson, PhD, RN; Xin Zhao, MS; Eric Peterson, MD, MPH; Gregg C. Fonarow, MD

2. Schwamm et al. Circulation. 2010 epub April 6 Disclosures The Get With The Guidelines– Stroke (GWTG) program is provided by the American Heart Association/American Stroke Association. The data analyzed in this manuscript was collected while the GWTG program was supported in part through an unrestricted educational grant from Boeringher-Ingelheim Pharmaceutical. The individual author disclosures are listed in the manuscript.

3. Schwamm et al. Circulation. 2010 epub April 6Schwamm et al. Background Prior studies suggest differences in stroke care associated with race/ethnicity. We sought to determine whether such differences existed in a population of black, Hispanic, and white patients hospitalized with stroke among hospitals participating in a quality- improvement program. Previous reports have demonstrated that participation in the Get With The Guidelines – Stroke (GWTG-Stroke), a national quality initiative of the American Heart Association, is associated with improved guideline adherence for patients hospitalized with Stroke.

4. Schwamm et al. Circulation. 2010 epub April 6Schwamm et al. Introduction Data supports that race/ethnicity related differences exist in stroke care. These differences could lead to increased risk of recurrent stroke. The burden of stroke is higher in black and Hispanic patients compared to white patients. 1 Several studies have suggested that ethnic/race differences exist in the quality of care and outcomes for hospitalized stroke patients. 2 1. Lloyd-Jones D et al. Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119:480-6. 2. Stansbury JP, Jia H, Williams LS, Vogel WB, Duncan PW. Ethnic disparities in stroke: epidemiology, acute care, and post acute outcomes. Stroke. 2005;36:374-86.

5. Schwamm et al. Circulation. 2010 epub April 6Schwamm et al. Objective The GWTG-Stroke Program has the potential to influence the quality of care and outcomes of ethnic patients hospitalized with stroke. The purpose of the paper was to evaluate whether race/ethnicity related differences exist in stroke care among hospitals participating in the GWTG-Stroke program.

6. Schwamm et al. Circulation. 2010 epub April 6Schwamm et al. Methods Data were collected from 397,257 patients admitted with ischemic stroke to 1181 hospitals participating in the GWTG-Stroke program were evaluated from April 1, 2003- September 30, 2008.  The hospitals were participating in the Get With the Guidelines–Stroke Program (GWTG-Stroke).  3 groups were analyzed: Black, Hispanic and White patients.  7 evidence-based performance measurements were used to evaluate the quality of care of these patients.  Hospital characteristics were evaluated.

7. Schwamm et al. Circulation. 2010 epub April 6 Patient Characteristics By Race Schwamm et al. Circulation. 2010 epub April 6 VariableLevelTotal NOverallWhiteBlackHispanic Total Study Pop397257 3142306356119466 AgeMedian Years (IQR) 74 (61-82)76 (64-83)64 (54-75)68 (56-78) GenderFemale 52.7352.5954.9247.79 Arrival ModeEMS 60.0961.3156.1254.57 Other 39.4138.2243.3244.82 Medical History Atrial Fib/FlutterYes 18.1220.388.8112.09 Stroke/TIAYes 30.6030.0033.9029.63 CAD/Prior MIYes 28.0429.6421.2324.39 Carotid StenosisYes 4.555.171.992.85 Diabetes MellitusYes 29.9526.9540.6843.25 PVDYes 5.205.484.094.18 HypertensionYes 74.2472.4782.5875.57 DyslipidemiaYes 36.1737.3930.5134.99 SmokerYes 19.3418.0826.4816.59

8. Schwamm et al. Circulation. 2010 epub April 6 Results Blacks were 16 percent less likely than whites to receive the clot-busting drug tissue plasminogen activator (tPA) and to receive anticoagulants for atrial fibrillation. Blacks were 12 percent less likely than whites to receive deep vein thrombosis prevention and to be discharged with anti-clotting medications. Blacks were 3 percent less likely than whites to receive early anti-clotting medications. Blacks were 9 percent less likely than whites to receive cholesterol- lowering therapy. Blacks were 15 percent less likely than whites and Hispanics were 18 percent less likely than whites to receive smoking cessation counseling. Overall, blacks were 10 percent less likely than whites to receive “defect free care,” which is defined as the proportion of patients who receive all of the interventions for which they are eligible. Schwamm et al. Circulation. 2010 epub April 6

9. GWTG-Stroke Adherence to Defect- Free Measure by Race/Ethnicity Schwamm et al. Circulation. 2010 epub April 6 Trend of improvement over time was significant within each patient group (black, Hispanic, white; P<0.001)

10. Schwamm et al. Circulation. 2010 epub April 6Schwamm et al. Results Hispanic patients received comparable quality of care and in- hospital mortality to that of white patients after adjustment for patient and hospital level variables, but a greater odds to exceed the median length of stay (OR 1.16; 1.11-1.20) and be discharged home (OR 1.13; 1.08-1.18) Black patients with stroke are at an increased risk of recurrent stroke because they received fewer evidence based care processes than Hispanic or white patients, but over the three time period, the quality of care differences were reduced for all three ethnic groups.

11. Schwamm et al. Circulation. 2010 epub April 6 Results Black (47.9 percent) and Hispanic (52.6 percent) patients were more likely to be discharged to home compared to white patients (44.0 percent), who were more likely to be discharged to a skilled nursing facility compared to black and Hispanic patients. Black (4.37 percent) and Hispanic (4.90 percent) patients were less likely than white patients (6.06 percent) to die in the hospital. Black (6.60 days) and Hispanic (6.34 days) patients had longer hospital stays than whites (5.49 days). Schwamm et al. Circulation. 2010 epub April 6

12. Schwamm et al. Limitations The GWTG-Stroke is a voluntary program and could over- represent high-performing hospitals. Hispanic ethnicity may be under-reported in this registry because of variability between hospitals in the process to establish patient ethnicity. Data were collected by chart review and thus depend on the accuracy and completeness of documentation. The GWTG-Stroke database does not track inpatient provider specialty, and this may influence mortality and quality of care.

13. Schwamm et al. Circulation. 2010 epub April 6Schwamm et al. Conclusion Black patients with stroke received fewer evidence-based care processes than Hispanic or white patients. These differences could lead to increased risk of recurrent stroke. Quality of care improved substantially in the Get With The Guidelines-Stroke Program over time for all 3 racial/ethnic groups.

14. Schwamm et al. Circulation. 2010 epub April 6 “These findings tell us that a focused, systematic quality improvement intervention, such as this, can improve care, regardless of race and ethnicity, what remains is to identify the causes of these differences in care among ethnic groups so we can develop strategies to eliminate that small but persistent disparity.” Lee Schwamm, MD GWTG Steering Committee Chair Schwamm et al. Circulation. 2010 epub April 6