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Supplementary Fig.1 Native expression Relative expression ratio vs. HKsRNAs a Relative expression ratio vs. pCMX DAOY Med8A Relative expression ratio vs. pCMX Stable overexpression b D458 Med Relative expression ratio vs. pCMX

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Supplementary Fig.1 Relative expression ratio vs. siCtrl Relative expression ratio vs. siCtrl Transient knockdown DAOY Med8A c Relative expression ratio vs. siCtrl D458 Med

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Supplementary Fig.2

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Supplementary Fig.3

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Molecular subgroup miR-182miR-183 miR-96 Supplementary Fig.4

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Supplementary Fig. 5

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Transient knockdown Day Metabolic activity, ratio vs. Day1 Metabolic activity, ratio vs. Day1 Stable overexpression Day Metabolic activity, ratio vs. Day1 Metabolic activity, ratio vs. Day1 DAOY Med8A * * ** Supplementary Fig. 6

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