1. Infertility in Men and Women with CF Julia Broaddus March 15, 2006

2. Infertility Inability to conceive after a year of trying Inability to conceive after a year of trying 33% -33%-15% 33% -33%-15%

3. Female Infertility Lower one-third of the uterus Lower one-third of the uterus Thicker cervical mucus Thicker cervical mucus

4. Male infertility Abnormal Vas Deferens Abnormal Vas Deferens CBAV CBAV

5. Successful Pregnancies Microsurgical epididymal sperm aspiration (MESA) Microsurgical epididymal sperm aspiration (MESA) Intracytoplasmic sperm injection Intracytoplasmic sperm injection 70% Successful 70% Successful

6. References Cystic Fibrosis and Infertility. http://www.3.nbnet.nb.ca/normap/cfinfertility.htm Cystic Fibrosis and Infertility. http://www.3.nbnet.nb.ca/normap/cfinfertility.htm http://www.3.nbnet.nb.ca/normap/cfinfertility.htm http://www.3.nbnet.nb.ca/normap/cfinfertility.htm Developmental Biology. Gilbert, Scott F., Sinauer Associates, Inc, Sutherland, Massachusetts. 6 th ed. 2000. pg.185-88 Developmental Biology. Gilbert, Scott F., Sinauer Associates, Inc, Sutherland, Massachusetts. 6 th ed. 2000. pg.185-88 Human Anatomy & Physiology. Shier, David., et al. WCB publishers, 7 th ed.1996. pg.859 Human Anatomy & Physiology. Shier, David., et al. WCB publishers, 7 th ed.1996. pg.859 Male Fertility.md. www.malefertility.md/diagnosis.html Male Fertility.md. www.malefertility.md/diagnosis.htmlwww.malefertility.md/diagnosis.html Pregnancy and Infertility. http://www.cysticfibrosismdicin.com/htmldocs/CText /pegancy.htm Pregnancy and Infertility. http://www.cysticfibrosismdicin.com/htmldocs/CText /pegancy.htm http://www.cysticfibrosismdicin.com/htmldocs/CText /pegancy.htm http://www.cysticfibrosismdicin.com/htmldocs/CText /pegancy.htm The Boomer Esiason Foundation-Cystic Fibrosis Infertility. http://esiason.org/newsResourcInfert.html The Boomer Esiason Foundation-Cystic Fibrosis Infertility. http://esiason.org/newsResourcInfert.html http://esiason.org/newsResourcInfert.html