1. caTissue Future 1 Feb 2013 Ian Fore, Juli Klemm, Lisa Mahoney, Jose Galvez & Cliff Wong

2. Outline Introduction & NCIP Status/release of caTissue 2.0 Revised support mechanisms NCI funded development of caTissue Open development Code Jamboree 2 User group meetings Discussion Summary

3. National Cancer Informatics Program Announced by Dr Harold Varmus, Director of NCI –April 2012 NCIP Blog –http://ncip.nci.nih.gov/bloghttp://ncip.nci.nih.gov/blog Twitter –@NCI_NCIP LinkedIn Group –NCIP - National Cancer Informatics Program

4. caTissue as a product - Three levels A product for use by end users –Web application A product for use by system integrators –Application Programmers Interface An open source product for customization by coders –Source code

5. caTissue Suite 2.0 - Thanks NCI management –Cliff Wong, Sichen Liu Development managed by SAIC-Frederick –Sreenath Nampally Development work by –Washington University in St Louis –Krishagni –Semantic Bits Contracted requirements and testing –Thomas Jefferson University –Emory University –Yale University Biospecimen Informatics Program Management –Booz Allen Hamiliton –Anna Fernandez, Beth DiGiulian, Lynn Martin caTissue user and developer community –Community Coders tested new build process - gratis

6. caTissue Suite 2.0 features – end user Ability to manage and represent Specimen Processing Procedures (SPPs) associated with individual collection protocols Use unique identifiers across organizations Ability to store and query age at collection Bulk operation enhancements Interoperability with assay systems such as caArray via MAGE-TAB files Integration with the NCI Clinical Trials Report Program (CTRP) data sources for person, organization, and studies Integration with patient registrations applications (e.g. C3PR) Publish summary information via CBM Many legacy bug fixes

7. caTissue Suite 2.0 features - technical Support for caGrid-based authentication and authorization in the Web application and caGrid API Single caGrid data service simplifies both "static" model and dynamic extension queries caGrid service now a full read-write biospecimen service Improved source code organization and build process that uses NCI Build and Deployment Automation (BDA) framework Many security issues addressed

8. Security Vulnerabilities in caTissue 73% of organizations have been hacked at least once in the past two years through insecure Web applications. 1 70% of threats occur with the application. 2 –As opposed to the server or other infrastructure NIH/NCI use a commercial web application scanner to search for vulnerabilities. A scan of caTissue 2.0 found a number of vulnerabilities that need remediation. The vulnerabilities are currently being addressed and testing is scheduled to complete in Feb. 2013 1. State of Web Application Security Survey, Ponemon Institute 2. Gartner Research

9. Status/release of caTissue 2.0 There remain some testing issues which are being resolved Security vulnerability Common Biorepository model export issues Release of caTissue Suite 2.0 will generate a need for support –Some compromises in the new release

10. caTissue Support Prior Support Mechanism –Knowledge Center - Closed May 2012 –Forums – active NCIP Application support –Phone: 240-276-5541 –Email: ncicbiit@mail.nih.govncicbiit@mail.nih.gov Community driven Support –Community support experts Community individuals supported by CBIIT as caTissue experts –Answer community questions from the listserve and forums –Create and maintain knowledge on the Wiki site –caTissue Wiki https://wiki.nci.nih.gov/display/TBPTKC/Tissue- Biospecimen+Banking+and+Technology+Tools+Knowledge+Ce nterhttps://wiki.nci.nih.gov/display/TBPTKC/Tissue- Biospecimen+Banking+and+Technology+Tools+Knowledge+Ce nter –Forums https://cabig-kc.nci.nih.gov/Biospecimen/forums/

11. Knowledge Center forums remain active

12. 2013 NCI funded development of caTissue NCI is working on doing some development through an appropriate mechanism Main objective –Increase suitability for development and contributions by a broad community –Engineering oversight will come from within NCI Expected to commence in second quarter 2013

13. Open development of caTissue Under NCIP Open Development Initiative –http://ncip.nci.nih.gov/blog/tag/open-development/http://ncip.nci.nih.gov/blog/tag/open-development/ NCIP GitHub –https://github.com/nciphttps://github.com/ncip Continue the strong line of caTissue open development

14. Center Name Washington UnivLouisiana Cancer Research Consortium Christiana Health Care Systems Indiana UnivJohn Hopkins Univ.Emory Univ. Dana Farber Cancer Institute Accelerated Community Oncology Research Network Univ. of Edinburgh Loma Linda Univ.Ohio State Univ.Univ. of Nebraska Huntsman Cancer Institute University of California, Davis Vrije Universiteit, Amsterdam Yale Univ.Univ. of MichiganC-DAC, Pune Washington Univ Louisiana Cancer Research Consortium Christiana Health Care Systems Indiana Univ John Hopkins Univ. Emory Univ. Dana Farber Cancer Institute Accelerated Community Oncology Research Network Univ. of Edinburgh Loma Linda Univ. Ohio State Univ. Univ. of Nebraska Huntsman Cancer Institute University of California, Davis Yale Univ. Univ. of Michigan caTissue Suite Community Development

15. Examples of recent community development Krishagni –caTissue Plus Vrije (Free) Universiteit – Amsterdam –Modifications to CBM export

16. Governance How will the future direction of caTissue be set? Establish a governance team –Not a single institution or company –An evolution of the caTissue Community Code group Identify community leadership for that group caLIMS 2 is already doing something similar –Some different considerations apply for caTissue

17. caTissue within NCIP NCI’s continuing interest includes –caTissue as a tool to improve biospecimen management and support best practices –caTissue as an interoperable application To enable cross disciplinary and cross institutional research Interoperability - the past –caTissue dynamic extensions is a unique example of the integration of an application with the caBIG infrastructure Interoperability - the future –Wish to see that continue as NCIP moves to Revised semantic infrastructure Revised interoperability framework –E.g. Make easier what was done by the Prostate SPOREs

18. Some mechanics Migration of caBIG source code to GitHub –From Subversion at NCI Timing to be determined for caTissue Opportunity for revising code modularization –Again! Issues to be addressed by the community code group

19. Community Code teleconference Items up for the agenda –SVN check in Review of request mechanism –GitHub migration –caTissue Plus code management Krishagni –CBM ETL revisions Vrije Universiteit Amsterdam –Security fixes SAIC team Please make other suggestions

20. The Code Jamboree It’s about the code –i.e. the third level It’s about the situations where… –There wasn’t enough money –There wasn’t enough time –We didn’t think about it –We got it “wrong” …and you want to change the code yourself Code Jamboree 2 In planning for 2013

21. User group meetings Goal –Learning about caTissue –Provide user feedback Program committee (as in 2011) –Drawn from users –Biobankers! Material –From the user community –Community Support Experts Location –To be determined

22. Putting the above together Community development alongside NCI development Jamboree and code community calls –Parallel threads of continued activity

23. Future meetings Biospecimen Informatics calls –Monthly User Group meeting –Annual Community code contributions –Monthly caTissue Code Jamboree –Annual/biannual

24. Discussion – the floor is yours But some possible topics… Some sites will not be comfortable with open source –Sceptical IT departments? –How can we help? How much does application security matter to you? Thoughts about revised support mechanisms Level of interest in code Jamboree Level of interest in User Group Meeting Other concerns/questions? This call is recorded unless you object –Please say so

25. Summary of links caTissue –Wiki https://wiki.nci.nih.gov/display/TBPTKC/Tissue- Biospecimen+Banking+and+Technology+Tools+Knowledge+Centerhttps://wiki.nci.nih.gov/display/TBPTKC/Tissue- Biospecimen+Banking+and+Technology+Tools+Knowledge+Center –Forums https://cabig-kc.nci.nih.gov/Biospecimen/forums/ –NCIP Application support Phone: 240-276-5541 Email: ncicbiit@mail.nih.govncicbiit@mail.nih.gov National Cancer Informatics Program –NCIP Blog http://ncip.nci.nih.gov/blog –Twitter @NCI_NCIP –LinkedIn Group –NCIP - National Cancer Informatics Program