1. Clinical trials Virtual tour Draft 2/19

2. Adobe Berdy Medical Carefx CommerceNet DCRI Dictaphone Digital Infuzion Eclipsys Epic GE Medical Systems Heartlab IBM INFINITT Kodak Kryptiq Microsoft Misys Mortara NIST Philips Medical Systems Raining Data Sentillion Siemens SNOMED XIMIS Clinical Trials: Integrating with patient care aECG Arden CCOW CDA CT EUA ODM PIX PSA RID RIM SDM SPL SWF V2 V3 Patients seen at PCP, hospitals ECGs sent to Core Lab; annotated on site or at Core Lab Hospital Core Lab Sponsor FDA PCP Imaging Central Lab

3. Adobe Berdy Medical Carefx CommerceNet DCRI Dictaphone Digital Infuzion Eclipsys Epic GE Medical Systems Heartlab IBM INFINITT Kodak Kryptiq Microsoft Misys Mortara NIST Philips Raining Data Sentillion Siemens SNOMED XIMIS Clinical Trials: Integrating with patient care Imaging aECG Arden CCOW CDA CT EUA ODM PIX PSA RID RIM SDM SPL SWF V2 V3 Patients seen at PCP, hospitals ECGs sent to Core Lab; annotated on site or at Core Lab Hospital Core Lab Sponsor FDA Registry Query broker, trusted 3 rd party Repository PCP Central Lab

4. Adobe Berdy Medical Carefx CommerceNet DCRI Dictaphone Digital Infuzion Eclipsys Epic GE Medical Systems Heartlab IBM INFINITT Kodak Kryptiq Microsoft Misys Mortara NIST Philips Raining Data Sentillion Siemens SNOMED XIMIS Clinical Trials: Integrating with patient care aECG Arden CCOW CDA CT EUA ODM PIX PSA RID RIM SDM SPL SWF V2 V3 Patients seen at PCP, hospitals ECGs sent to Core Lab; annotated on site or at Core Lab

5. Adobe Berdy Medical Carefx CommerceNet DCRI Dictaphone Digital Infuzion Eclipsys Epic GE Medical Systems Heartlab IBM INFINITT Kodak Kryptiq Microsoft Misys Mortara NIST Philips Raining Data Sentillion Siemens SNOMED XIMIS Clinical Trials: Integrating with patient care aECG Arden CCOW CDA CT EUA ODM PIX PSA RID RIM SDM SPL SWF V2 V3 Patients seen at PCP, hospitals ECGs sent to Core Lab; annotated on site or at Core Lab

6. Adobe Berdy Medical Carefx CommerceNet DCRI Dictaphone Digital Infuzion Eclipsys Epic GE Medical Systems Heartlab IBM INFINITT Kodak Kryptiq Microsoft Misys Mortara NIST Philips Raining Data Sentillion Siemens SNOMED XIMIS Clinical Trials: Integrating with patient care aECG Arden CCOW CDA CT EUA ODM PIX PSA RID RIM SDM SPL SWF V2 V3 Intervals for Analysis imported into Clinical Data Management System at Core Lab [sb aECG w/annotations; is ODM]

7. LDM data Adobe Berdy Medical Carefx CommerceNet DCRI Dictaphone Digital Infuzion Eclipsys Epic GE Medical Systems Heartlab IBM INFINITT Kodak Kryptiq Microsoft Misys Mortara NIST Philips Raining Data Sentillion Siemens SNOMED XIMIS Clinical Trials: Integrating with patient care aECG Arden CCOW CDA CT EUA ODM PIX PSA RID RIM SDM SPL SWF V2 V3 Interval Data for Analysis written in CDISC SDM and ODM for delivery to Sponsor

8. Adobe Berdy Medical Carefx CommerceNet DCRI Dictaphone Digital Infuzion Eclipsys Epic GE Medical Systems Heartlab IBM INFINITT Kodak Kryptiq Microsoft Misys Mortara NIST Philips Raining Data Sentillion Siemens SNOMED XIMIS Clinical Trials: Integrating with patient care aECG Arden CCOW CDA CT EUA ODM PIX PSA RID RIM SDM SPL SWF V2 V3 Interval Data for Analysis written in CDISC SDM and ODM for delivery to Sponsor

9. Adobe Berdy Medical Carefx CommerceNet DCRI Dictaphone Digital Infuzion Eclipsys Epic GE Medical Systems Heartlab IBM INFINITT Kodak Kryptiq Microsoft Misys Mortara NIST Philips Raining Data Sentillion Siemens SNOMED XIMIS Clinical Trials: Integrating with patient care aECG Arden CCOW CDA CT EUA ODM PIX PSA RID RIM SDM SPL SWF V2 V3 Patients seen at PCP, hospitals ECGs sent to Core Lab; annotated on site or at Core Lab

10. Adobe Berdy Medical Carefx CommerceNet DCRI Dictaphone Digital Infuzion Eclipsys Epic GE Medical Systems Heartlab IBM INFINITT Kodak Kryptiq Microsoft Misys Mortara NIST Philips Raining Data Sentillion Siemens SNOMED XIMIS Clinical Trials: Integrating with patient care Patients seen at PCP, hospitals ECGs sent to Core Lab; annotated on site or at Core Lab aECG Arden CCOW CDA CT EUA ODM PIX PSA RID RIM SDM SPL SWF V2 V3 Sample SDM

11. Adobe Berdy Medical Carefx CommerceNet DCRI Dictaphone Digital Infuzion Eclipsys Epic GE Medical Systems Heartlab IBM INFINITT Kodak Kryptiq Microsoft Misys Mortara NIST Philips Raining Data Sentillion Siemens SNOMED XIMIS Clinical Trials: Integrating with patient care Patients seen at PCP, hospitals ECGs sent to Core Lab; annotated on site or at Core Lab aECG Arden CCOW CDA CT EUA ODM PIX PSA RID RIM SDM SPL SWF V2 V3 Sample SDM Screen shot of patient profile viewer

12. Adobe Berdy Medical Carefx CommerceNet DCRI Dictaphone Digital Infuzion Eclipsys Epic GE Medical Systems Heartlab IBM INFINITT Kodak Kryptiq Microsoft Misys Mortara NIST Philips Medical Systems Raining Data Sentillion Siemens SNOMED XIMIS Clinical Trials: Integrating with patient care Imaging aECG Arden CCOW CDA CT EUA ODM PIX PSA RID RIM SDM SPL SWF V2 V3 PCP Patients seen at PCP, hospitals ECGs sent to Core Lab; annotated on site or at Core Lab Hospital Core Lab Sponsor FDA Lab

13. Adobe Berdy Medical Carefx CommerceNet DCRI Dictaphone Digital Infuzion Eclipsys Epic GE Medical Systems Heartlab IBM INFINITT Kodak Kryptiq Microsoft Misys Mortara NIST Philips Raining Data Sentillion Siemens SNOMED XIMIS Clinical Trials: Integrating with patient care Imaging Lab aECG Arden CCOW CDA CT EUA ODM PIX PSA RID RIM SDM SPL SWF V2 V3 PCP Patients seen at PCP, hospitals ECGs sent to Core Lab; annotated on site or at Core Lab Hospital Core Lab Sponsor FDA Registry Query broker, trusted 3 rd party Repository Lab