1. 1 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Featuring Demographic, Charge, Pharmacotherapy and Hospital Utilization Data for Diabetes Patients South Carolina Market Brief Diabetes

2. 2 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Sample Managed Care Digest Series ® Data Sets Patient Claims Data (Diabetes, AFib/AFlutter, Oncology): National, Regional, State, MSA Data – 2012 Data Hospital Profile and Discharge Data (59 Disease States): National, Regional, State, MSA, System and Individual Hospital Data – 2011 Data Health Plan Data (HMOs): National, Regional, State and MSA Data – 2012 Data Retail Pharmacy Data (60+ Drug Classes/Subclasses): National, Regional and State Data – Midyear 2012 Data (updated to midyear 2013 in September)

3. 3 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Tracking Patients Across the Continuum of Care LRx Retail Rx Specialty Rx Mail Rx LTC Rx Medical Medical Claims EMR/EHR Datasets Laboratory Values Health Plan Data Hospital Hospital Claims Charge Detail Master Patient Counts by Hospital

4. 4 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Diabetes patient claims data are generated by IMS Health for the Managed Care Digest Series ® using health care professional and institutional insurance claims. In 2012, data represented more than 7.1 million unique patients nationally with a diagnosis of Type 2 diabetes. Data from physicians of all specialties and from all hospital types are included. IMS Health also gathers data on prescription activity from the National Council for Prescription Drug Programs (NCPDP). These data account for some 2 billion prescription claims annually, or more than 50% of the prescription universe. These prescription data represent the sampling of prescription activity from a variety of sources, including retail chains, mass merchandisers and pharmacy benefit managers. Cash, mail order, Medicaid and third-party transactions are tracked. Diabetes Patient Claims Data

5. 5 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Percentage of Type 1 and Type 2 Diabetes Patients, by Payer, 2012 MedicareMedicaidCommercial Insurance 1 MarketType 1Type 2Type 1Type 2Type 1Type 2 Charleston29.6%44.5%11.8%7.8%58.6%45.3% Columbia21.9%43.4%16.5%6.8%58.5%48.4% Florence29.7%49.2%19.0%13.9%51.3%35.9% Greenville22.5%46.7%15.8%8.0%61.7%44.3% Myrtle Beach—52.6%—8.3%—37.5% Sumter—49.2%—10.7%—36.9% South Carolina27.5%47.3%14.9%9.0%55.8%42.3% NATION19.0%39.1%10.9%9.8%69.2%50.5% 1 Includes HMOs, PPOs, point-of-service plans and exclusive provider organizations. NOTE: Throughout this presentation, the Charleston market includes North Charleston, and the Greenville market includes Spartanburg and Anderson. Some demographic data for Type 1 diabetes patients were unavailable for Myrtle Beach and Sumter.

6. 6 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Percentage of Type 1 Diabetes Patients, by A1c Level Range 1 ≤7.0%7.1–7.9%8.0–9.0%>9.0% Market201020112012201020112012201020112012201020112012 South Carolina30.0%29.0%32.9%24.6%24.7%21.7%16.7%18.4%18.8%28.8%27.8%26.7% NATION28.2%27.7%28.1%26.5%26.1%25.5%22.4%22.0% 22.9%24.2%24.4% 1 The A1c test measures how much glucose has been in the blood during the past 2–3 months. Note: A1c level data data were unavailable for Type 1 diabetes patients in Charleston, Columbia, Florence, Greenville, Myrtle Beach and Sumter. Some A1c level data were unavailable for Greenville.

7. 7 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 ≤7.0%7.1–7.9%8.0–9.0%>9.0% Market201020112012201020112012201020112012201020112012 Charleston46.5%48.0%44.8%22.5%20.5%21.8%13.7%13.0%13.6%17.3%18.6%19.9% Columbia47.2%49.2%45.8%20.9%19.9%21.0%14.5%12.6%13.4%17.4%18.3%19.9% Florence48.5%47.3%45.9%21.9%19.5%18.9%13.3% 13.9%16.3%19.8%21.3% Greenville50.2%54.1%51.3%22.1%19.5%19.2%13.2%12.3%13.6%14.5%14.1%15.9% Myrtle Beach50.3%51.5%48.8%23.3%21.9%21.3%13.8%12.0%14.2%12.6%14.6%15.7% Sumter50.2%50.7%47.2%23.6%19.7%19.4%12.4%13.4%12.6%13.8%16.1%20.9% South Carolina48.5%50.7%47.4%22.0%20.1%20.4%13.7%12.4%13.7%15.8%16.8%18.6% NATION50.2%51.1%50.6%22.0%20.7%20.6%13.3%12.6%12.9%14.6%15.6%15.9% Percentage of Type 2 Diabetes Patients, by A1c Level Range 1 1 The A1c test measures how much glucose has been in the blood during the past 2–3 months.

8. 8 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Percentage of Type 1 Diabetes Patients, by Actual Complication, 2012 1 Market Cardiovascular Disease HypoglycemiaNephropathyNeuropathyRetinopathy Charleston45.3%9.4%25.5%28.3%41.5% Columbia58.7%—22.8%30.4%35.9% Florence44.1%—49.2%20.3%22.0% Greenville36.0%13.7%26.6%38.1%27.3% South Carolina46.0%13.5%31.3%32.6%28.1% NATION35.9%16.5%27.3%28.7%32.8% 1 A complication is defined as a patient condition caused by the Type 1 diabetes of the patient. These conditions are a direct result of having Type 1 diabetes. Complications of Type 1 diabetes include, but are not limited to, cardiovascular disease, hypoglycemia, nephropathy, neuropathy and retinopathy. Note: Some complications data were unavailable for Columbia and Florence.

9. 9 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Percentage of Type 2 Patients, by Actual Complication, 2012 1 Market Cardiovascular Disease HypoglycemiaNephropathyNeuropathyRetinopathy Charleston52.6%9.0%27.7%32.5%29.7% Columbia63.9%4.8%21.2%30.0%19.8% Florence67.9%6.3%33.8%30.5%11.3% Greenville61.4%7.7%29.7%35.5%12.5% Myrtle Beach66.6%8.9%23.2%37.3%15.9% Sumter57.8%9.5%36.6%42.2%20.5% South Carolina61.7%7.4%28.0%33.6%16.3% NATION58.1%7.3%29.6%31.3%18.5% 1 A complication is defined as a patient condition caused by the Type 2 diabetes of the patient. These conditions are a direct result of having Type 2 diabetes. Complications of Type 2 diabetes include, but are not limited to, cardiovascular disease, hypoglycemia, nephropathy, neuropathy and retinopathy.

10. 10 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Percentage of Type 2 Diabetes Patients, Using Various Insulin Therapies Long-Acting Insulin Rapid-Acting Insulin Short-Acting Insulin Market201020112012201020112012201020112012 Charleston21.3%21.8%22.0%13.9%14.4%14.0%15.6%15.8%15.0% Columbia20.1%21.6%23.1%14.2%14.9%16.5%15.3%16.1%17.3% Florence26.0%27.8%27.2%17.6%18.4%18.2%18.6%19.1%18.7% Greenville21.6%22.3%23.0%13.4%13.7% 14.8%14.9%14.6% Myrtle Beach20.9%21.9%22.8%12.8%13.2%14.0%14.5%14.7%15.4% Sumter25.3%24.7%24.6%18.8%19.4%19.2%19.7%20.3%19.7% South Carolina21.6%22.5%23.2%14.1%14.5%14.8%15.5%15.7%15.8% NATION23.0%23.6%24.9%14.9%15.3%16.0%17.0%17.1%17.6%

11. 11 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Percentage of Type 2 Diabetes Patients, Using Various Therapies Intermediate-Acting Insulin Mixed Insulin 2+ Non-Insulin Products Market201020112012201020112012201020112012 Charleston2.7%2.5%2.1%7.9%7.1%6.5%24.8%25.1%22.6% Columbia2.1% 1.6%8.1%7.5%6.9%26.3%26.4%23.9% Florence2.2%1.8%1.5%9.9%9.3%9.2%23.5%23.0%22.5% Greenville2.8%2.3%1.8%7.5%6.5%5.8%26.5%26.4%24.1% Myrtle Beach2.5%2.1%2.2%6.4%6.0% 7.5%7.4%6.2% Sumter2.3%1.9%1.6%8.3%6.9% 7.1%7.8%6.2% South Carolina2.5%2.2%1.8%7.7%6.9%6.4%26.3% 24.1% NATION2.7%2.3%2.0%6.7%6.0%5.7%29.3%28.4%26.7%

12. 12 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Any Insulin Products Long-Acting Insulin Rapid-Acting Insulin VialsPensVialsPens Market%$%$%$%$%$ Charleston32.3%$1,8958.4%$1,04615.2%$1,2746.9%$1,4608.4%$1,156 Columbia33.0%$2,1578.2%$1,22016.6%$1,3667.0%$1,47610.7%$1,188 Florence38.2%$2,25111.3%$1,23118.1%$1,4457.7%$1,21012.1%$1,476 Greenville31.9%$2,10010.0%$1,34014.5%$1,4146.7%$1,5488.0%$1,301 Myrtle Beach32.6%$2,0609.1%$1,37515.1%$1,4546.8%$1,2648.0%$1,287 Sumter34.5%$2,0938.9%$1,09317.1%$1,2337.5%$1,54013.0%$1,190 South Carolina32.8%$2,0799.4%$1,25215.3%$1,3737.0%$1,4559.0%$1,261 NATION33.9%$2,07911.3%$1,25615.3%$1,3348.0%$1,4139.2%$1,303 Percentage of and Average Annual Payments 1 for Type 2 Diabetes Patients Using Various Insulin Therapies, 2012 1 Figures reflect the per-patient yearly payments for Type 2 diabetes patients receiving a particular type of therapy. These are the actual amounts paid by the insurer and patient for such prescriptions. Costs mainly include copayments, but can also include tax, deductibles and cost differentials where applicable.

13. 13 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Percentage of and Average Annual Payments 1 for Type 2 Diabetes Patients Using Various Insulin Therapies, 2012 Short-Acting Insulin Mixed Insulin Intermediate-Acting Insulin VialsPensVialsPensVialsPens Market%$%$%$%$%$%$ Charleston8.1%$1,4178.4%$1,1563.8%$1,2463.1%$1,8961.7%$6070.4%$936 Columbia7.8%$1,43310.7%$1,1883.8%$1,4063.7%$2,1101.4%$7210.3%$1,366 Florence8.6%$1,23012.1%$1,4765.7%$1,2754.2%$2,2531.5%$684—— Greenville7.8%$1,4558.0%$1,3013.6%$1,3682.5%$1,8791.6%$9720.3%$1,021 Myrtle Beach8.4%$1,1658.0%$1,2873.7%$1,3542.5%$2,1911.9%$8630.3%$1,351 Sumter8.1%$1,55813.0%$1,1904.5%$1,3333.1%$1,9821.5%$834—— South Carolina8.1%$1,3949.0%$1,2613.9%$1,3442.9%$1,9951.6%$8160.3%$1,027 NATION9.8%$1,3339.2%$1,3033.5%$1,3452.6%$1,9561.8%$7820.3%$1,164 1 Figures reflect the per-patient yearly payments for Type 2 diabetes patients receiving a particular type of therapy. These are the actual amounts paid by the insurer and patient for such prescriptions. Costs mainly include copayments, but can also include tax, deductibles and cost differentials where applicable. Note: Some pharmacotherapy data were unavailable for the selected markets.

14. 14 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Any Non-Insulin Antidiabetic Product Insulin Sensitizing Agents (TZDs) GLP-1 Receptor Agonists DPP-4 Inhibitors Market%$%$%$%$ Charleston85.0%$7605.6%$1,5307.0%$1,98111.5%$1,418 Columbia82.8%$7476.4%$1,5355.9%$1,89112.0%$1,452 Florence81.6%$7359.0%$1,5114.3%$1,90611.9%$1,540 Greenville85.7%$6317.0%$1,6563.6%$1,89310.3%$1,495 Myrtle Beach84.6%$7528.1%$1,6465.6%$2,13011.3%$1,465 Sumter83.5%$8825.0%$1,4707.5%$2,01215.0%$1,604 South Carolina84.6%$7046.8%$1,6045.0%$1,93611.4%$1,473 NATION84.6%$7457.1%$1,6504.9%$1,96412.8%$1,525 Percentage of and Average Annual Payments 1 for Type 2 Diabetes Patients Using Various Non-Insulin Antidiabetic Therapies, 2012 1 Figures reflect the per-patient yearly payments for Type 2 diabetes patients receiving a particular type of therapy. These are the actual amounts paid by the insurer and patient for such prescriptions. Costs mainly include copayments, but can also include tax, deductibles and cost differentials where applicable.

15. 15 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 1 Figures reflect the per-patient yearly payments for Type 2 diabetes patients receiving a particular type of therapy. These are the actual amounts paid by the insurer and patient for such prescriptions. Costs mainly include copayments, but can also include tax, deductibles and cost differentials where applicable. Average Annual Payments per Type 2 Diabetes Patient, by Type of Therapy, 2012 1

16. 16 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 EndocrinologyPrimary Care 1 Internal Medicine Market Long- Acting Insulin Rapid- Acting Insulin Short- Acting Insulin Inter- mediate -Acting Insulin Long- Acting Insulin Rapid- Acting Insulin Short- Acting Insulin Inter- mediate -Acting Insulin Long- Acting Insulin Rapid- Acting Insulin Short- Acting Insulin Inter- mediate -Acting Insulin Charleston34.2%41.4%43.3%8.0%17.9%8.1%8.8%5.8%20.9%12.0%12.8%6.1% Columbia43.7%50.0%51.2%4.4%19.3%11.6%12.3%7.7%21.9%13.1%14.0%6.1% Florence35.9%49.2%50.8%11.6%23.5%12.8%13.3%8.9%29.0%18.7%19.8%6.1% Greenville44.8%50.4%53.0%4.3%20.3%10.0%10.7%4.8%21.9%11.9%12.8%6.9% Myrtle Beach29.1%32.1%32.9%4.0%18.8%9.4%10.6%6.3%21.7%11.4%10.6%5.9% Sumter42.9%47.2% —19.3%13.4%13.9%5.0%20.0%8.8%15.1%8.8% South Carolina38.7%43.8%45.7%5.4%19.5%10.1%10.9%6.0%22.2%12.7%13.6%6.6% NATION37.0%36.0%38.1%7.1%21.0%10.7%12.0%4.8%22.0%12.4%13.9%5.5% Percentage of Type 2 Diabetes Patients Using Various Insulin Therapies, by Prescribing Specialist, 2012 1 “Primary care” consists of both general and family practitioners.

17. 17 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Persistency: Various Insulin Products, South Carolina, 2012

18. 18 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Persistency: Various Non-Insulin Antidiabetic Products, South Carolina, 2012

19. 19 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Persistency: Various Insulin Therapies, Charleston, 2012

20. 20 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Persistency: Various Non-Insulin Antidiabetic Therapies, Charleston, 2012

21. 21 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Persistency: Various Insulin Therapies, Greenville, 2012

22. 22 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Persistency: Various Non-Insulin Antidiabetic Therapies, Greenville, 2012

23. 23 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Readmission Rates for Patients Diagnosed with Type 2 Diabetes, by Type of Therapy, 2010–2012 1

24. 24 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Professional Charges per Year for Type 2 Diabetes Patients, 2012 1 Market Ambulatory Surgery Emergency Room Hospital Inpatient Hospital Outpatient Office/Clinic Charleston$3,321$730$3,747$1,269$2,154 Columbia$2,539$1,228$3,088$1,312$2,039 Florence$2,421$722$4,080$1,240$2,010 Greenville$2,208$652$2,664$973$2,172 Myrtle Beach$3,544$557$2,629$1,093$2,019 Sumter$3,462$884$3,152$1,995$3,898 South Carolina$2,713$749$2,987$1,182$2,068 NATION$2,475$946$2,769$1,096$1,846 1 Professional charges are those generated by the providers delivering care to Type 2 diabetes patients in various settings.

25. 25 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 InpatientOutpatient Market Charleston$17,019$3,777 South Carolina$19,518$3,366 NATION$33,161$6,750 Facility Charges per Year for Type 1 Diabetes Patients, 2012 1 1 Figures reflect the charges generated for Type 2 diabetes patients by the facilities that delivered care. Facility charge data include charges for all services rendered, including prevention and charges associated with the treatment of other diseases. The data also reflect the average amounts charged in Type 2 diabetes patient claims, not the amount the claims paid. Note: Facility charges data were unavailable for Type 1 diabetes patients in Columbia, Florence, Greenville, Myrtle Beach and Sumter.

26. 26 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 InpatientOutpatient Market2011201220112012 Charleston$40,935$46,177$8,560$8,199 Columbia$43,724$48,111$8,499$7,932 Florence$47,617$49,623$8,121$11,791 Greenville$43,347$48,325$11,417$9,514 Myrtle Beach$40,591$40,881$7,995$8,077 Sumter$40,887$36,450$7,632$9,106 South Carolina$40,178$44,463$8,218$8,109 NATION$49,150$52,156$10,061$10,647 Facility Charges per Year for Type 2 Diabetes Patients 1 1 Figures reflect the charges generated for Type 2 diabetes patients by the facilities that delivered care. Facility charge data include charges for all services rendered, including prevention and charges associated with the treatment of other diseases. The data also reflect the average amounts charged in Type 2 diabetes patient claims, not the amount the claims paid.

27. 27 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Hospital Discharges

28. 28 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 InpatientOutpatient MarketAverageTotalAverageTotal Charleston1,717.115,4547,466.959,735 Columbia2,881.814,40911,681.258,406 Florence2,798.08,3947,729.723,189 Greenville1,559.421,8318,244.298,930 Myrtle Beach1,257.85,0317,763.723,291 South Carolina1,425.695,5186,064.2382,043 NATION1,282.86,382,1335,251.425,574,123 Total and Average Number of Inpatient and Outpatient Diabetes Mellitus Cases per Hospital, 2011 Note: For slides 25–29, diabetes mellitus hospital discharge data were unavailable for Sumter.

29. 29 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 MarketMedicareMedicaidCommercial Insurance 1 Charleston59.3%9.6%18.1% Columbia54.4%12.7%22.6% Florence70.0%9.2%15.3% Greenville66.7%9.6%16.8% Myrtle Beach64.3%9.9%16.6% South Carolina63.8%10.3%17.8% NATION60.1%11.9%19.8% Percentage of Inpatient Diabetes Mellitus Cases, by Payer, 2011 1 Includes HMOs, PPOs, point-of-service plans and exclusive provider organizations.

30. 30 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 MarketPrimarySecondary Charleston8.0%92.0% Columbia8.4%91.6% Florence9.3%90.7% Greenville8.2%91.8% Myrtle Beach7.6%92.4% South Carolina8.7%91.3% NATION8.5%91.6% Percentage of Inpatient Diabetes Mellitus Cases, by Primary vs. Secondary Diagnosis, 2011

31. 31 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Market Home/Routi ne Short Term Hospital Skilled Nursing Facility Intermediate Care Facility Other Facility 1 Home Health Against Advice DiedOther 2 Charleston71.1%0.7%8.5%0.6%0.4%14.0%0.2%1.0%3.5% Columbia69.2%0.8%10.7%0.7%0.4%14.2%0.3%1.1%2.7% Florence73.4%1.1%7.1%0.7%0.4%11.2%0.5%1.3%4.4% Greenville68.6%0.9%10.8%1.2%0.6%13.9%0.3%1.0%2.6% Myrtle Beach68.5%1.4%9.9%0.8%0.2%14.9%0.6%1.6%2.1% South Carolina68.3%1.5%10.4%0.8%0.4%14.1%0.3%1.2%2.9% NATION63.3%2.0%12.9%1.0%1.2%15.0%0.9%1.2%2.5% Percentage of Inpatient Diabetes Mellitus Cases, by Discharge Destination, 2011 1 “Other Facility” represents patients discharged or transferred to federal health care facilities, Medicare-certified long-term hospitals or critical-access hospitals. 2 “Other” represents mental health/rehabilitation, shelters, hospice (home) and hospice (medical facility).

32. 32 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 ALOSAverage Charges 1 Market2010201120102011 Charleston5.14.7$44,250$42,209 Columbia6.46.8$44,338$43,340 Florence5.05.5$40,005$53,399 Greenville—4.8$36,810$36,537 Myrtle Beach5.24.4$30,416$27,724 South Carolina5.34.6$34,089$35,614 NATION4.3 $34,505$36,624 Average Length of Stay (Days) and Total Average Charges per Inpatient Diabetes Mellitus Case 1 Data reflect the average amounts charged, not the amounts paid. Charges include the treatment of other diseases besides diabetes mellitus. Note: Some average length of stay data were unavailable for Greenville.

33. 33 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Most Common Concomitant Diagnoses for Patients With a Primary Diagnosis of Diabetes Mellitus, 2011 South Carolina Hospitals ICD-9 CODEDescriptionOverall 401.9Unspecified Essential Hypertension 21.1% 272.4Other and Unspecified Hyperlipidemia 12.4% 584.9Unspecified Acute Renal Failure 11.0% 276.51Dehydration 8.3% 707.15Ulcer of Other Part of Foot 7.7% 305.1Nondependent Tobacco Use Disorder 6.9% 357.2 Polyneuropathy in Diabetes 6.7% 403.90 Hypertensive Chronic Kidney Disease, Unspecified, with Chronic Kidney Disease, Stage I through Stage IV, or Unspecified 6.5% NOTE: Most common concomitant diagnoses data are available down to the state level only.

34. 34 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 Most Common Procedures for Patients With a Primary Diagnosis of Diabetes Mellitus, 2011 NOTE: Most common procedures data are available down to the state level only South Carolina Hospitals ICD-9 CODEDescriptionOverall 39.95Hemodialysis 7.5% 38.93Venous Catheterization, Not Elsewhere Classified 7.0% 99.04Transfusion of Packed Cells 6.5% 86.22Excisional Debridement of Wound, Infection or Burn 3.0% 38.97Central Venous Catheter Placement with Guidance 2.1% 88.48Ateriography of Femoral and Other Lower Extremity Artery 1.7%

35. 35 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013

36. 36 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S., A SANOFI COMPANY Data source: IMS Health © 2013 Claims Data (slides 5–26) Data for this presentation were generated by IMS Health for the Managed Care Digest Series ® using health care professional and institutional insurance claims. Data for this presentation represent more than 7.2 million unique patients nationally in 2012 with a diagnosis of Type 1 or Type 2 diabetes. Data from physicians of all specialties and from all hospital types are included. IMS Health also gathers data on prescription activity from the National Council for Prescription Drug Programs (NCPDP). These data account for some 2 billion prescription claims annually, or more than 50% of the prescription universe. These prescription data represent the sampling of prescription activity from a variety of sources, including retail chains, mass merchandisers and pharmacy benefit managers. Cash, mail order, Medicaid and third-party transactions are tracked. Hospital Procedure/Diagnosis (HPD) Discharge Data (slides 28–34): Demographic, utilization and charge data are derived from IMS Health’s HPD database. This database contains an extensive set of hospital inpatient discharge records, including actual diagnosis and procedure data for about 75% of all discharges nationwide (including 100% of Medicare-reimbursed discharges). IMS Health uses Medicare procedure counts and additional hospital-level information to estimate procedure counts for the remaining 25% of discharges—the non-Medicare hospital discharge information in non-reporting states. The HPD inpatient database also reports the numbers of procedures performed on patients discharged from a hospital. The hospital inpatient data provided are current as of calendar year 2011. Methodology

37. 37 Managed Care Digest Series ®, © 2013 sanofi-aventis U.S. LLC, A SANOFI COMPANY Data source: IMS Health © 2013 MarketType 1 DiabetesType 2 Diabetes Charleston, SC24820,911 Columbia, SC30224,505 Florence, SC17010,980 Greenville, SC49942,406 South Carolina1,690155,833 NATION141,6207,139,402 Claims Data Sample Sizes