1. Human Anatomy & Physiology Ninth Edition C H A P T E R 14 © 2013 Pearson Education, Inc.© Annie Leibovitz/Contact Press Images The Autonomic Nervous System 7/4/20121MDufilho

2. Autonomic Nervous System (ANS) ANS consists of motor neurons that –Innervate smooth and cardiac muscle, and glands –Make adjustments to ensure optimal support for body activities –Operate via subconscious control Also called involuntary nervous system or general visceral motor system 7/4/20122

3. MDufilho Figure 14.1 Place of the ANS in the structural organization of the nervous system. Central nervous system (CNS)Peripheral nervous system (PNS) Sensory (afferent) division Motor (efferent) division Somatic nervous system Autonomic nervous system (ANS) Sympathetic division Parasympathetic division 7/4/20123

4. MDufilho Somatic Versus Autonomic Nervous Systems Both have motor fibers Differ in –Effectors –Efferent pathways and ganglia –Target organ responses to neurotransmitters 7/4/20124

5. MDufilho Figure 14.2 Comparison of motor neurons in the somatic and autonomic nervous systems. Cell bodies in central nervous system Peripheral nervous system Neurotransmitter at effector Effector organs Effect SOMATIC NERVOUS SYSTEM AUTONOMIC NERVOUS SYSTEM SYMPATHETIC PARASYMPATHETIC Single neuron from CNS to effector organs Heavily myelinated axon ACh Skeletal muscle Stimulatory Two-neuron chain from CNS to effector organs Lightly myelinated preganglionic axons Ganglion Nonmyelinated postganglionic axon Epinephrine and norepinephrine ACh Adrenal medulla Blood vessel Lightly myelinated preganglionic axon Ganglion ACh Nonmyelinated postganglionic axon ACh Smooth muscle (e.g., in gut), glands, cardiac muscle Stimulatory or inhibitory, depending on neuro- transmitter and receptors on effector organs Acetylcholine (ACh)Norepinephrine (NE) NE + + – 7/4/20125

6. MDufilho Role of the Parasympathetic Division – D activities Promotes maintenance activities and conserves body energy –Directs digestion, diuresis, defecation As in person relaxing and reading after a meal –Blood pressure, heart rate, and respiratory rates are low –Gastrointestinal tract activity high –Pupils constricted; lenses accommodated for close vision 7/4/20126

7. MDufilho Role of the Sympathetic Division – E activities Mobilizes body during activity; "fight-or- flight" system Exercise, excitement, emergency, embarrassment –Increased heart rate; dry mouth; cold, sweaty skin; dilated pupils During vigorous physical activity –Shunts blood to skeletal muscles and heart –Dilates bronchioles –Causes liver to release glucose 7/4/20127

8. MDufilho Parasympathetic Sympathetic Eye Salivary glands Brain stem Cranial Sympathetic ganglia Salivary glands Heart Cervical Lungs T1T1 Heart Stomach Thoracic Pancreas Stomach Pancreas Liver and gall- bladder L1L1 Liver and gall- bladder Lumbar Adrenal gland Bladder Genitals Sacral Genitals Skin* Figure 14.3 The subdivisions of the ANS. 7/4/20128

9. Application Work as a group on chart MDufilho 7/4/20129

10. MDufilho Neurotransmitters Cholinergic fibers release neurotransmitter ACh –All ANS preganglionic axons –All parasympathetic postganglionic axons at effector synapse Adrenergic fibers release neurotransmitter NE –Most sympathetic postganglionic axons –Exception: sympathetic postganglionic fibers secrete ACh at sweat glands 7/4/201210

11. MDufilho Figure 14.2 Comparison of motor neurons in the somatic and autonomic nervous systems. Cell bodies in central nervous system Peripheral nervous system Neurotransmitter at effector Effector organs Effect SOMATIC NERVOUS SYSTEM AUTONOMIC NERVOUS SYSTEM SYMPATHETIC PARASYMPATHETIC Single neuron from CNS to effector organs Heavily myelinated axon ACh Skeletal muscle Stimulatory Two-neuron chain from CNS to effector organs Lightly myelinated preganglionic axons Ganglion Nonmyelinated postganglionic axon Epinephrine and norepinephrine ACh Adrenal medulla Blood vessel Lightly myelinated preganglionic axon Ganglion ACh Nonmyelinated postganglionic axon ACh Smooth muscle (e.g., in gut), glands, cardiac muscle Stimulatory or inhibitory, depending on neuro- transmitter and receptors on effector organs Acetylcholine (ACh)Norepinephrine (NE) NE + + – 7/4/201211

12. MDufilho Cholinergic Receptors Two types of receptors bind ACh 1.Nicotinic – always stimulatory 2.Muscarinic – both stimulatory and inhibitory depending on the organ Named after drugs that bind to them and mimic ACh effects 7/4/201212

13. MDufilho Adrenergic Receptors Two major classes –Alpha (  ) (subtypes  1,  2 ) –Beta (  ) (subtypes  1,  2,  3 ) Effects of NE depend on which subclass of receptor predominates on target organ 7/4/201213

14. 7/4/2012 MDufilho14 Effects of Drugs Epinephrine (adrenaline) –Hormone released or drug –Sympathomimetic effect –Hormone is released during “flight or fight” –Given as drug during heart attacks and anaphylactic shock - improve blood pressure and circulation –Binds to all adrenergic receptors (  1,  2,  1,  2,  3 ) – mimicks effect of NE –Active ingredient in OTC inhalers

15. 7/4/2012 MDufilho15 Effects of Drugs Albuterol – Proventil or Ventolin –Sympathomimetic effects – selective –Binds to  2 receptors – dilation of bronchioles –Given to asthma patients – relieves bronchospasms

16. 7/4/2012 MDufilho16 Effects of Drugs Propanolol (Inderal) –Sympatholytic effects –Rx as a “beta blocker to control hypertension –Vessels of skin and viscera receive constant impulses from sympathetic neurons – sympathetic tone –Action - decrease the number of sympathetic impulses from medulla to blood vessels – vasodilation and reduced blood pressure –Action – Binds and blocks NE receptors to heart – decreases heart rate to reduce cardiac output and BP

17. MDufilho Effects of Drugs Atropine –Anticholinergic; blocks muscarinic ACh receptors –Used to prevent salivation during surgery, and to dilate pupils for examination Neostigmine –Inhibits acetylcholinesterase that breaks down ACh –Used to treat myasthenia gravis 7/4/201217

18. MDufilho Effects of Drugs Over-the-counter drugs for colds, allergies, and nasal congestion –Stimulate  -adrenergic receptors Beta-blockers –Drugs that attach to  2 receptors to dilate lung bronchioles in asthmatics; other uses See Table 14.3 p. 535 7/4/201218

19. MDufilho Sympathetic Tone Sympathetic division controls blood pressure, even at rest Vascular system ~ entirely innervated by sympathetic fibers Sympathetic tone (vasomotor tone) –Keeps blood vessels in continual state of partial constriction 7/4/201219

20. MDufilho Sympathetic Tone Sympathetic fibers fire more rapidly to constrict blood vessels and cause blood pressure to rise Sympathetic fibers fire less rapidly to prompt vessels to dilate to decrease blood pressure Alpha-blocker drugs interfere with vasomotor fibers –Used to treat hypertension 7/4/201220

21. MDufilho Parasympathetic Tone Parasympathetic division normally dominates heart, smooth muscle of digestive and urinary tract organs, activate most glands except for adrenal and sweat glands –Slows the heart –Dictates normal activity levels of digestive and urinary tracts The sympathetic division can override these effects during times of stress Drugs that block parasympathetic responses increase heart rate and cause fecal and urinary retention 7/4/201221

22. MDufilho Control of ANS Function Hypothalamus—main integrative center of ANS activity Subconscious cerebral input via limbic system structures on hypothalamic centers Other controls come from cerebral cortex, reticular formation, and spinal cord 7/4/201222

23. MDufilho Communication at subconscious level Cerebral cortex (frontal lobe) Limbic system (emotional input) Hypothalamus The “boss”: Overall integration of ANS Brain stem (reticular formation, etc.) Regulates pupil size, heart, blood pressure, airflow, salivation, etc. Spinal cord Reflexes for urination, defecation, erection, and ejaculation Figure 14.8 Levels of ANS control. 7/4/201223

24. MDufilho Homeostatic Imbalances of the ANS Hypertension (high blood pressure) –Overactive sympathetic vasoconstrictor response to stress –Treated with adrenergic receptor - blocking drugs Raynaud's disease –Exaggerated vasoconstriction in fingers and toes Pale, then cyanotic and painful Treated with vasodilators 7/4/201224

25. MDufilho Homeostatic Imbalances of the ANS Autonomic dysreflexia –Uncontrolled activation of autonomic neurons in quadriplegics and those with spinal cord injuries above T 6 –Blood pressure skyrockets –Life-threatening 7/4/201225

26. MDufilho Developmental Aspects of the ANS Effects of age on ANS –Constipation –Dry eyes –Frequent eye infections –Orthostatic hypotension Low blood pressure after position change Pressure receptors less responsive to blood pressure changes Cardiovascular centers fail to maintain healthy blood pressure 7/4/201226