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Published byFelicity Lee Modified over 9 years ago
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4% of all female cancers 25% of all gynecologic cancers life time risk: 1/70 ¾ advanced stage most lethal Epithelial Ovarian Cancer:
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serous (75 – 80%) mucinous (10%) endometrioid (10%) Brenner, clear cell, undif. (1%) 15% Borderline Classification of EOC:
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100 % 1344 15.3%206Metastatic 7.2%97Germ 9.2%124 Sex-cord stromal 67.6%908Epithelial %NTYPE Ovarian Malignancies in Hacettepe
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Stage distribution of EOC (Hacettepe) STAGE I II III IV 235 105 385 186 908
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1.4%13Other 2.1%19Brenner 6.2%56Mixed 5.9%54Undifferentiated 3.3%30 Clear Cell 9.0%82Endometrioid 18.7%170Mucinous 53.3%484Serous %NTYPES Histological Subtypes of EOC (Hacettepe)
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Therapy in EOC: age, performance extent of tumor fertility desire histologic subtypes gradegrade othersothers
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Treatment M O D A L I T I E S M O D A L I T I E S SurgerySurgeryAdjuvantAdjuvantSupportiveSupportive Stoma... ComplementaryComplementary Fertility saving CytoreductiveCytoreductive ChemotherapyChemotherapy RadiotherapyRadiotherapy StagingStaging NutritionNutrition Second look Bowel surgery PsychosomaticPsychosomatic Whole abd. 32 P Platin based
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Aim of Surgery AccurateDiagnosisAccurateDiagnosis Extent of tumor tumor Prognostic information Decision for final Treatment
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Goal of Cytoreduction Removal of ALL Primary & Whole metastatic tumors Or at least less than 1cm
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Cytoreduction Primary Cytoreduction Secondary Cytoreduction Interval Debulking Cytoreductive Surgery
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What is the Definition of “OPTIMAL STATUS” and why? 40 months <5mm 18 months 5-10mm 6 months 15mm Median SurvDiameter At least 1gr or 1cm Diameter Griffiths, Hoskins (GOG), Hacker, Berek... At least 1gr or 1cm Diameter Griffiths, Hoskins (GOG), Hacker, Berek...
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For effective Cytoreduction ExperienceExperience UpperabdominaltumorUpperabdominaltumor Inherent factors of tumor itself Retroperitoneal tumor Fixed Pelvic mass
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Cytoreductive Surgery Bowel resection Liver resection SplenectomyLymphadenectomy Diaphragmatic peritoneal resection Bowel resection Liver resection SplenectomyLymphadenectomy Diaphragmatic peritoneal resection TAH+BSOTAH+BSO Total Omentectomy Resection of all metastatic tumor and related organs
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48Splenectomy 10Cystectomy 12 Ileal/Ileachecal resection 57 Sigmoid resection NPROCEDURE Additional Surgical Procedures During Cytoreduction (Hacettepe)
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Bowel Resection For Optimal cytoreduction (%87)For Optimal cytoreduction (%87) To Prevent or treat obstructionTo Prevent or treat obstruction
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Debulking Hacettepe Experience (N=673) SUBOPTİMAL 22.6% 77.4 % OPTİMAL
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What is the Role of Cytoreduction in Stage IV Bristow 1999 Liver (84 pts) Optimal Debulking Liver (84 pts) Optimal Debulking Parenchymal debulking No parenchymal debulking 50 months 25 months
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Lymphadenectomy in Advanced Ovarian Cancer Performed Not performed 59 % 16 % Lymphadenectomy 2yr Survival Scarabelli et al, di Re F et al.
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OUTCOME OF OPTIMAL CYTOREDUCTION Optimal Cytoreduction Median Survival Progression Free Survival + (n=388) 36,7 months 33,5 months (n=200) - (n=537) 16,6 months 15,0 months (n=374) Hoskins et al., Boardman et al.
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CHEMOTHERAPY PLATIN BASED 58 % NON-PLATIN BASED 42 %
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EPITHELIAL OVARIAN CANCER 5-yr OS (%) Stage I-II Stage III-IV % 88 % 38
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5-yr OS (%) with respect to second look laparotomy (n=254)
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Interval Cytoreduction Second look Surgery Second look Surgery Cytoreduction Cytoreduction Suboptimal Surgery Suboptimal Surgery 3 cycle chemotherapy 3 cycle chemotherapy 3 cycle chemotherapy EORTC and Ongoing GOG
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Cytoreduction after Neoadjuvant Chemotherapy 3 cycle chemotherapy Initially inappropriate for Surgery Tissue diagnosis CYTOREDUCTIONCYTOREDUCTION Park et al, Schwartz et al,...
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CONCLUSION Advanced Stage Ovarian Cancer Optimal Cytoreduction Paclitaxel+PlatinPaclitaxel+Platin
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CONCLUSION Advanced Stage Ovarian Cancer Suboptimal surgery: Interval debulking Poor performance or unresectable tumor: Neo-adjuvant chemotherapy
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Thank you...
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