1. How many stages of cell division do you see in this image?

2. Cells reproduce by a cycle of growing and dividing called the cell cycle.

3. ) Cell Cycle Mitosis will be our main focus. First, we will look at Interphase… This graph is NOT to scale!!

4. Interphase ) Longest stage of cell cycle (90%) Nucleus is visible Cell is growing during G 1 and G 2 and DNA is being replicated (copied) during S.

5. Interphase: 3 Phases ) 1.G 1 : Cell is Growing 2.S: DNA is Synthesized (DNA Replication) 3.G 2 : Cell growth; Organelles duplicate in preparation for division Most of these cells are in Interphase

6. Limits to Cell Growth 6150750 1125 661.2 Total Surface Area: Height x Width x Number of sides x Number of boxes Total Volume: Height x Width x Length x Number of boxes Surface-to-volume ratio: Surface Area/ Total Volume

7. What’s the problem with a low surface-to-volume ratio? 1.There are not enough materials entering the cell to meet its demands 2.Materials have trouble leaving the cell. 3.The cell can’t make enough mRNA or proteins to meet the demands of the cell. O2O2 O2O2 CO 2

8. What are the key roles of cell division? Cell division functions in: –Reproduction for some organisms –Growth of an organism from a fertilized egg –Repair of cells that die from normal wear and tear or accidents Cell division distributes identical sets of chromosomes to daughter cells

9. Key Vocabulary DNA molecules are packaged into. –Human (body cells) have 46 –Human (sperm or eggs) have 23 Chromosomes are made of a material called. chromosomes somatic cells gametes chromosomes. chromatin

10. Key Vocabulary Chromatin is composed of and. DNA is supercoiled around proteins called. Together the DNA and histone proteins form bead-like structures called DNA proteins histones nucleosomes Histones DNA Chromosome

11. Key Vocabulary sister chromatids centromere S interphase The chromosome is duplicated during ___ in _____________. Each duplicated chromosome consists of two. These are connected by a.

12. Mitosis (M Phase) The M Phase consists of: Mitosis and Cytokinesis Four Stages of Mitosis: P rophase M etaphase A naphase T elophase

13. Late Interphase: G 2 Centrosomes (with centriole pairs) Preparing for Division 1.Nuclear membrane still visible Nucleolus 2.Chromatin has been replicated

14. Late Interphase: G 2 Preparing for Division 4.Chromosome consisting of two sister chromatids Centromere Early Spindle Apparatus Prophase 3.Nuclear membrane disappears

15. Metaphase 5. Chromosomes line up at an imaginary line between the centrosomes at opposite ends of the cell. 6.The spindle attaches to the centromeres.

16. Anaphase 7.Spindles pull the “daughter” chromosomes appart

17. Telophase & Cytokinesis Telophase 8. Two nuclei become visible In animal cells, a cleavage furrow is visible In plant cells, a cell plate is now visible Cytokinesis 9.The cytoplasm and organelles divide.

18. Interphase: 3 Phases ) 1.G 1 : Cell is Growing 2.S: DNA is Synthesized (DNA Replication) 3.G 2 : Organelles duplicate in preparation for division RE-identify the stages of Mitosis

19. What’s the end product? Two identical daughter cells ready to start the cycle again… or not. Some cells (like your nerve and muscle cells) do not undergo division. For those that do (your skin and the lining of your intestinal tract) how would you know how quickly division takes place?