2. Patients and professionals need, and have a right to, clean, clear knowledge just as they need clean clear knowledge

5. Better Decisions User needs assessment Production & Procurement Organisation Localisation & Mobilisation Utilisation National Knowledge Service Question Answering Service

6. Best Current Knowledge Service National Library for Public Health National Public Health Knowledge Network Public and professionals

7. The aim of the Best Current Knowledge Service is to ensure that a common core of knowledge from research, data and experience based on explicit quality standards and user needs is collected and regularly updated

8. What we know - 3 types of generalisable knowledge Knowledge from research - Evidence Knowledge from measurement of healthcare performance-Statistics Knowledge from experience-Of patients and clinicians These need to be linked to 2 types of particular knowledge Knowledge about this population Knowledge about this public health service

9. For 28,737 original and review articles published in 110 journals in 2004 [ 556 (1.93%)] met critical appraisal criteria and were rated…for relevance most articles in clinical journals are not appropriate for direct application by individual clinicians Haynes RB et al (2006) Second order peer review of the medical literature for clinical practitioners JAMA 295:1801-1808

10. 40% [of 186 trials that were published in 10 prestigious journals] neglected to declare the nature and success of follow-up of patients Hall JC et al (1998) Surgery on trial; an account of trials evaluating surgical operations Surgery 124;22-27

11. our data suggest that reported applications [of molecular genetics] in clinical journals often have troubling omissions, deficiencies and lack of attention to the different but necessary, principles of clinical epidemiological science Bogardus ST et al (2006) Clinical epidemiological quality in molecular genetic research JAMA 281; 1919-1926

12. reliability and relevance of current systematic reviews of diagnostic tests is compromised by poor reporting and review methods Mallett S et al (2006) Systematic reviews of diagnostic tests in cancer; review of methods and reporting Brit Med J doi;10.1136/bmj.38895.467130.55 18 july

13. 50% of efficacy and 65% of harm outcomes were incompletely reported.86% of survey respondents (42/49) denied the existence of unreported outcomes despite evidence to the contrary…Published articles, as well as the reviews that incorporate them, may therefore be unreliable and over estimate the benefits of an intervention Chan AW et al (2004) Empirical evidence of selective reporting for outcomes in controlled trials JAMA 291; 2457-65

14. our data suggest that 40 reported [medical] applications [of molecular genetics] in [4 general] clinical journals often have troubling omissions, deficiencies and lack of attention to the different,but necessary, principles of clinical epidemiological science Bogardus ST et al (1999) Clinical epidemiological quality in molecular genetic research; the need for methodological standards JAMA 281; 1919-1926

15. Study (research) protocols Study reports (journal articles) Systematic reviews & Guidelines based on systematic reviews Synopses (structured abstracts) Summaries Systems: clinical tools

16. Study (research) protocols Study reports (journal articles) Systematic reviews & Guidelines based on systematic reviews Synopses (structured abstracts) Summaries Systems: clinical tools Procured Produced

17. The National Knowledge Management Network + The National Digital Knowledge Base + the community of readers = National Library for Health. The NLH consists of 3 key resources:

18. The aim National Clinical Decision Support Service is to ensure that any computer based decision support system for clinicians and patients not only use best current knowledge but also have been demonstrated as doing more good than harm in ordinary service settings

19. The false positive rate [for Hepititis C] is especially important in low prevalence settings where the number of false positives may exceed the number of true positives Booth JCL et al (2001) Gut 49 (Suppl 1) i4 column 1 Section 3.1 lines 23-27

20. What it really looks like

21. Royal Cornwall Lab Service Muir Gray 21/06/1944 NHS number 400 186 6897 ELISA25.5 Hepatitis C is of low prevalence in Cornwall. National guidance is that diagnosis should be confirmed by PCR test in low prevalence populations For PCR test click here For access to full text of guidance click here To test your knowledge in one minute click here

22. The National Knowledge Service will organise National Knowledge Weeks which will deliver Annual Reviews of Evidence, Process, Outcome and Configuration

23. The Annual Evidence Analysis will be prepared by the relevant National Specialist Library and will present the knowledge produced in the preceding year which conforms to explicit quality standards, priority will be given to a National Library of Systematic Reviews

26. Ignorance is like cholera; it cannot be controlled by the individual alone it requires the organised efforts of society; ensuring equal access to pure knowledge is a public health responsibility