1. Importance of Vitamin D Where is your level at on the scale? Presented by Andrea Fennell Kaplan University HW499 April 18, 2011

2. Introduction  Vitamin D Overview  Medical Importance  Are you deficient?  Reasons many are deficient  Video discussing Chronic disease prevention  Vitamin D and Cancer  Role in Heart Disease

3. Vitamin D Overview  Steroid – structured hormone  Is produced photochemcically or consumed via dietary or supplementation  Fat Soluble/found naturally but not in many foods  Exists in 2 forms that matter to humans: Vitamin D2 & Vitamin D3  Can be obtained from sun exposure(sunlight produces syntheisis)  Needed for bone growth/cell growth/ proper immune function  Reduces inflammation Ruxton, C. H., & Derbyshire E. (2009). Health impacts of vitamin D: are we getting enough? Nutrition Bulletin, 34 (issue 2), 185- 197. Retrieved from http://web.ebscohost.com.lib.kaplan.edu/ehost/detail?vid=15&hid=15&sid=abb95248-5822-4a78-864e- 600e6e40a877%40sessionmgr115&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=aph&AN=40120409Nutrition Bulletinhttp://web.ebscohost.com.lib.kaplan.edu/ehost/detail?vid=15&hid=15&sid=abb95248-5822-4a78-864e- 600e6e40a877%40sessionmgr115&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=aph&AN=40120409

4. Medical Importance Why we should maintain adequate levels  Less chance of Cancers  Decreased Cardiovascular Disease  Better Osteoarthritis/Skeletal Health  Less Falls in Seniors  Lowered Autoimmune Disease risks  Decrease in Diabetes Type 1 & Type 2  Reduces inflammation  Less risks in Pregnancy  Must supplement with Lactation Avalier, E., & Delanaye, P., & Chapelle, J., Souberbielle J. (2009). Vitamin D current status and perspectives. Clinical Chemistry & Laboratory Medicine, 47(2), 120-127. Retrieved from http://web.ebscohost.com.lib.kaplan.edu/ehost/detail?vid=17&hid=15&sid=abb95248-5822-4a78-864e- 600e6e40a877%40sessionmgr115&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=aph&AN=36354806Clinical Chemistry & Laboratory Medicine http://web.ebscohost.com.lib.kaplan.edu/ehost/detail?vid=17&hid=15&sid=abb95248-5822-4a78-864e- 600e6e40a877%40sessionmgr115&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=aph&AN=36354806

5. Are you Deficient? nmol/L** ng/mL*Health status <30<12 Associated with vitamin D deficiency, leading to rickets in infants and children and osteomalacia in adults 30–5012–20 Generally considered inadequate for bone and overall health in healthy individuals ≥50≥20 Generally considered adequate for bone and overall health in healthy individuals >125>50 Emerging evidence links potential adverse effects to such high levels, particularly >150 nmol/L (>60 ng/mL) Office of Dietary Supplement National Institutes of Health Fact Sheet: Vitamin D. Retrieved from http://ods.od.nih.gov/factsheets/VitaminD-HealthProfession http://ods.od.nih.gov/factsheets/VitaminD-HealthProfession

6. Video: Vitamin & Prevention of Chronic Disease Speaker is Michael F. HolickPHD, MD from Boston University http://www.youtube.com/watch?v=Cq1t9Wq OD-0&feature=related Discussion post video

7. Role in Heart Disease Framingham Heart Study has reinforced the idea that vitamin D is good for the heart (study conducted over a 30 year period) 1,700 middle-aged men chosen initially w/o heart disease. Those with low vitamin D levels were more likely to develop cardiovascular problems Those with normal vitamin D levels were less likely to have heart disease Vitamin D deficiency and risk of cardiovascular disease http://www.ncbi.nlm.nih.gov/pubmed/18180395

8. Vitamin D & Cancer Breast Prostate/Ovarian ColonPancreas Lung Epidemiologic data suggest that vitamin D status could affect cancer risk National Cancer Institute Fact Sheet (2011). Vitamin D and Cancer Prevention: Strengths and Limits of the Evidence Retrieved from http://www.cancer.gov/cancertopics/factsheet/prevention/vitamin-Dhttp://www.cancer.gov/cancertopics/factsheet/prevention/vitamin-D

9. Conclusion Vitamin D is just not to needed to make bones stronger. It is a hormone that does many things in tissues to different parts of the body. The new ongoing evidence is that vitamin D has numerous benefits. Are you deficient? If you are not sure ask you health provider to check your levels. New research is linking low vitamin D levels with many disease don’t put your health at risk.

10. RESOURCES Avalier, E., & Delanaye, P., & Chapelle, J., Souberbielle J. (2009). Vitamin D current status and perspectives. Clinical Chemistry & Laboratory Medicine, 47(2), 120-127. Retrieved from http://web.ebscohost.com.lib.kaplan.edu/ehost/detail?vid=17&hid=15&si d=abb95248-5822-4a78-864e- 600e6e40a877%40sessionmgr115&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d %3d#db=aph&AN=36354806Clinical Chemistry & Laboratory Medicine http://web.ebscohost.com.lib.kaplan.edu/ehost/detail?vid=17&hid=15&si d=abb95248-5822-4a78-864e- 600e6e40a877%40sessionmgr115&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d %3d#db=aph&AN=36354806 Miller J., & Gallo R. L. (2010). Vitamin D and innate immunity. Dermatologic Therapy, 23, 13-22. Retrieved from http://web.ebscohost.com.lib.kaplan.edu/ehost/detail?vid=25&hid= 15&sid=abb95248-5822-4a78-864e- 600e6e40a877%40sessionmgr115&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d %3d#db=aph&AN=47657480Dermatologic Therapy

11. RESOURCES COUNTINUED National Cancer Institute Fact Sheet (2011). Vitamin D and Cancer Prevention: Strengths and Limits of the Evidence Retrieved form http://www.cancer.gov/cancertopics/factsheet/prevention/vitamin-Dhttp://www.cancer.gov/cancertopics/factsheet/prevention/vitamin-D Office of Dietary Supplement National Institutes of Health Fact Sheet: Vitamin Retrieved from http://ods.od.nih.gov/factsheets/VitaminD-HealthProfession http://ods.od.nih.gov/factsheets/VitaminD-HealthProfession Ruxton, C. H., & Derbyshire E. (2009). Health impacts of vitamin D: are we getting enough? Nutrition Bulletin, 34 (issue 2), 185-197. Retrieved from http://web.ebscohost.com.lib.kaplan.edu/ehost/detail?vid=15&hid=15&sid=abb95248- 5822-4a78-864e- 600e6e40a877%40sessionmgr115&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=aph&AN= 40120409Nutrition Bulletinhttp://web.ebscohost.com.lib.kaplan.edu/ehost/detail?vid=15&hid=15&sid=abb95248- 5822-4a78-864e- 600e6e40a877%40sessionmgr115&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=aph&AN= 40120409

12. Questions and answers