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Vitamin D and Cancer Dorothy Teegarden, Ph.D. Purdue University Professor and Associate Head for Research, Department of Nutrition Science Lead, Cancer.

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Presentation on theme: "Vitamin D and Cancer Dorothy Teegarden, Ph.D. Purdue University Professor and Associate Head for Research, Department of Nutrition Science Lead, Cancer."— Presentation transcript:

1 Vitamin D and Cancer Dorothy Teegarden, Ph.D. Purdue University Professor and Associate Head for Research, Department of Nutrition Science Lead, Cancer Prevention and Control Program, Oncological Sciences Center Director, Interdisciplinary Cancer Prevention Internship Program

2 Vitamin D is Metabolized and Acts Like a Hormone Blood 25 hydroxyvitamin D Status Indicator 1, 25 hydroxyvitamin D Active Hormone Sunlight Visit 1 25OHD levels N = 206

3 Raw Data Sheets Assay Method:LC/MS-MRM Assay Date:10/11 - 10/13/10 Sample volume:250 uL Limit of Results Key:Quantification 25-(OH) VD310pg/mL (0.025nM) 25-(OH) VD210pg/mL (0.024nM) Assay Results: ClientConcentration [nM] Sample #25-(OH) VD325-(OH) VD225-(OH) VD [Total] 0591SE04151.51.8153.4 0261SE0480.81.382.1 0391SE04118.135.8153.8 Assay Notes: 1 Total Samples Assayed:74 2Validation of Results Quality Control (QC) samples NIST Standard Reference Material 972 Name25-(OH) VD325-(OH) VD2 nM SRM 972 Level 347.563.8 SRM 972 Level 351.266.0 SRM 972 Level 351.466.8 SRM 972 Level 352.965.8 SRM 972 Level 347.562.4 average50.165.0 Standard derivation2.471.81 NIST Reference Values; Standard Reference Material 972 Level 3 NIST Level 325-(OH) VD325-(OH) VD2 nM Average assay result50.165.0 Reference value46.2±2.864.1±4.8 % Difference8.4%1.3% Multiple Sheets Does not distinguish between first and second visits Excess information on sheet not needed for analysis Select data, down load, merge for each analysis

4 Results in Format for Analysis Patient Barcode BD1: FileNo BD1: AliquotID BD1: 25- (OH) VD3 (nM) BD1: 25- (OH) VD2 (nM) BD1: 25- (OH) VD (nM) BD2: FileNo BD2: AliquotID BD2: 25- (OH) VD3 (nM) BD2: 25- (OH) VD2 (nM) BD2: 25- (OH) VD (nM) 110011SE04108.24.9113.2----- 210021SE0469.11.770.8----- 310031SE0491.11.492.5----- 410041SE04783.781.7----- 510051SE0460.31.561.8----- 610061SE04171.21.2172.4----- 710071SE04134.84.5139.3----- 910091SE0467.71.569.210092SE0492.91.794.6 -One excel sheet -Linked to clinical data -Formatted for easy analysis

5 Results Data Summary of the First Visit Diagnosis 25-(OH) VD3 (nM) 25-(OH) VD2 (nM) 25-(OH) VD Total (nM) Sample size Colorectal Healthy Polyps 87.9 83.2 81.4 4 8.6 6.7 91.9 91.8 88.1 31 88 87

6 Leveraging CCE HUB and Available Results Vitamin D and metabolomics Breast CCE International Breast Cancer and Nutrition – Global

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