1. University of Guanajuato Campus Celaya Salvatierra Division of Health Sciences and Engineering Department of Nursing and Obstetrics Dr. Nicolas Padilla Raygoza

2. Medical Doctor, University Autonomous of Guadalajara and University National Autonomous of Mexico, 1984 Pediatrician, Mexican Council of Certification of Pediatrics, N° 2870, 1986 Postgrade in Epidemiology. University of London, 2002 Master and Doctorate in Sciences in focus in Epidemiology, Atlantic International University, 2006 Professor Associate C and Coordinator of Support to Research and Postgraduate Studies, Department of Nursing and Obstetrics, Division of Health Sciences and Engineering, Campus Celaya Salvatierra University of Guanajuato

3. To describe main characteristics of rotavirus To identify susceptible people to rotavirus To identify the symptoms and signs from rotavirus infection To describe laboratory studies to diagnosis of rotavirus infection To identify and describe the treatment

4. Rota= wheel Family Reoviridae Discovery in 1973 by Dra. Ruth Bishop It appear as a bicycle wheel Seven groups: A, B, C, D, E, F, G. Only A, B. C cause enteritis. Resistant They will survive in the environment

5. Unwrapped Double capsule Measure 70 nm Genome 11 RNA segments Encode six structural proteins and five non-structural. Group A 14 serotypes accord to VP7 protein (G) 20 serotypes accord protein VP4 (P) G and P have multiple combinations

6. Cause more severe and acute diarrhea in children: 111 millions of cases require ambulatory care 25 millions of medical consultations 2 millions of hospitalized patients From 352,000 to 592,000 deaths of children.

7. Children from 6 months to 2 years Pre term newborns Elderly Immunocompromised Traveler diarrhea or sub clinic disease in adults

8. World wide distribution

9. Peaks in winter and summer November - December April-May

10. Fecal oral Person to person, Foods, Food handlers, Fomites Airway

11. Infectiousness period 1 – 3 días Contagiousness 8 days >30 days in immunocompromised Sudden onset with (6 days): Vomit, disappear in 24-48 hours Fever, disappear suddenly Profuse watery diarrhea Dehydration Diminish the activity of lactase

12. Detection of antigen of Rotavirus in feces Immunoassay quick test Electrophoresis of RNA from genome viral Staining with silver nitrate Immunosobernt assay

13. There is not a specific treatment Non- suspend feeding To change at soy formula Oral rehydration NON-ANTIBIOTICS

14. To change at soy formula Soy with fiber for 5 days Only soy for 15 days Comeback to habitual milk Oral rehydration 100 – 120 ml/kg/during 6 hours in low or absent dehydration 120 ml/kg/during 6 hours in moderate dehydration IV rehydration in severe dehydration

15. NON-ANTIBIOTICS Aminoglycosides Lactase deficiency aggravates Diarrhea aggravates Increase the anxiety of family Increase needed of hospitalization

16. Thank you