1. Robert Jeraj Associate Professor of Medical Physics, Human Oncology, Radiology and Biomedical Engineering Director of Wisconsin Oncology Network of Imaging eXcellence University of Wisconsin Carbone Cancer Center, Madison, WI

2. Wisconsin Oncology Network  Aspirus Regional Cancer Center, Wausau  Aurora Cancer Care  Aurora HealthCare Network  Bellin Memorial Hospital, Green Bay  Columbia-St. Mary’s, Milwaukee  Dean Clinic Heme/Onc  Ferguson Cancer Center, Freeport, IL  Fox Valley Heme/Onc  Gundersen Lutheran, La Crosse  Holy Family Cancer Center, Manitowoc  Marshfield Clinic  Medical College of Wisconsin, Milwaukee  Mercy Health System, Janesville  ProHealth Care, Waukesha and Oconomowoc  St. Vincent Hospital, Green Bay  SwedishAmerican Hospital/SAH Regional Cancer Center, Rockford, IL  UWCCC  UWCCC Partners, Johnson Creek, Wisconsin Rapids  Vucurevich Cancer Center, Rapid City, SD

3. Wisconsin Oncology Network of Imaging Excellence (WONIX)

4. WONIX organizational structure

5. Molecular Imaging Agents Working Group  To develop molecular imaging agents and make them available to the WONIX sites. It includes development of necessary distribution infrastructure and necessary regulatory documentation for obtaining Investigator New Drug (IND) approvals.  Chairs: –Scott Perlman, Co-Chair –Rebecca Marnocha, Co-Chair  Members: John Centanni, Scott Knishka, Yongjun Yan, Todd Barnhart, Robert Jeraj, Anne Traynor, Dona Alberti

6. Imaging quality assurance Working Group  To establish “harmonized” imaging quality assurance program across the WONIX sites.  Chairs: –Chihwa Song, Co-Chair –Matt La Fontaine, Co-chair  Members: Robert Pyzalski, Karl Vigen, Frank Ranallo, Frank Korosec, Sean Fain, Guanghong Chen, Ed Jackson, Robert Jeraj, Nagesh Adluru, Chris Jaskowiak, Cheryl Gain

7. Informatics Working Group  To enable automated workflows, data collection and integration, and processes that enable scalable clinical trials within WONIX  Chairs: –Richard Bruce, Co-chair –Sean Fain, Co-Chair  Members: Gary Wendt, Andy Craven, Chihwa Song, Matt La Fontaine, Cheryl Gain, Jonathon Boott

8. Data Working Group  To develop common database platform and appropriate tools for data analysis and data mining  Chairs: –Umberto Tachinardi (Co-chair) –Jonathan Boott (Co-chair)  Members: Stephine Wasielewski, Mary Jane Staab, Jill Kolesar, Richard Bruce, Robert Jeraj, Dona Alberti

9. Imaging clinical trials Working Group  To design, coordinate and execute individual imaging clinical trial projects through the WONIX network.  Chairs: –Robert Jeraj, Co-Chair –Glenn Liu, Co-chair  Members: George Wilding, Anne Traynor, Ryan Mattison, Kari Wisinski, Scott Perlman, Jill Kolesar, Dona Alberti, Jennifer Heideman

10. Clinical trials  Retrospective analysis of FDG PET/CT in NSCLC –Current UW pilot (20 pts) will be extended (200 pts) through WONIX  MITOS: FDG PET/CT in NSCLC –Comprehensive genomic analysis and CTCs –Early and late FDG PET/CT response assessment –Piloted (3 pts) at UWCCC; WONIX amendments –Soon to be activated through WONIX  NaF PET/CT in mCRPC  FDG PET/CT in lymphoma  FLT PET/CT in AML  …

11. Next steps  WONIX working groups: –Molecular imaging agents: cGMP facility (Q1 2015) –Imaging QA: Automated QA/QC monitoring (Q3 2015) –Informatics: XDS data exchange platform (Q2 2015) –Data: Common databased established (Q3 2015)  WONIX site activation (Q4 2014/Q1 2015) –Gundersen, La Crosse (Q4 2014) –St. Vincent, Green Bay (Q1 2015) –Others to follow  WONIX clinical trial activation (Q1/Q2 2015) –Retrospective FDG PET/CT analysis (Q1 2015) –MITOS trial (Q2 2015) –Others to follow

12. WONIX Site Visit with Gundersen Health System, La Crosse

13. Monthly newsletter

14. Monthly update at the TIR meeting

15. WONIX Website

16. WONIX Wiki

17. Questions wonix@lists.wisc.edu