1. Blood Vessels and Hemodynamics

2. Types of blood vessels Arteries divide – Elastic (conducting) arteries – Muscular arteries Arterioles branch into Capillaries reunite to form Venules merge into Veins converge and convey blood back to the heart

4. Arteries Elastic arteries or conducting arteries – Pressure reservoirs – Recoil of elastic fibers propels the blood. Muscular or distributing arteries – Constrict or dilate to adjust blood flow.

5. Arterioles Small arteries (10-300mm) that deliver blood to capillaries. Regulates blood flow Regulates blood pressure

6. Continuous Capillaries

7. Fenestrated capillaries

8. Sinusoidal capillaries

9. Capillary beds: Microcirculation Vascular shunt True capillaries

10. Capillary exchange Vasomotion is slow and intermittent

11. Venules and veins Capillaries unite and form venules Venules converge and form veins Veins – No elastic layers – Large lumen – Valves Sinuses

12. Venous return Overcoming resistance and the force of gravity. Skeletal muscle pump Respiratory pump Sympathetic control

14. Arteries Strong thick elastic walls Narrow lumens Closer to pumping action of heart Veins Thinner walls, larger lumens Valves Enhanced by skeletal activity

15. Arteries and Veins Anastomoses is the union of two or more branches of arteries. Varicose veins are caused by leaky venous valves that cause veins to become dilated and twisted.

16. Varicose Veins Normal flow in veins. The calf muscle contacts forcing the blood past one way valves that only allow the blood to move heartward. Refluxing (backward) flow of blood in varicose veins. The calf muscle forces blood upwards past one way valves with contraction. With relaxation the faulty valves allow the blood to fall back down the leg (reflux) with gravity. The backward flow (reflux) in affected veins causes them to engorge and enlarge as well as to twist taking on the characteristic appearance of varicose veins. Because the blood tends to pool rather than circulate the relatively “stagnant” blood irritates nearby muscles, muscle and skin causing pain and is more likely to clot as well

17. Physiology of blood Blood flow (ml/min) Blood pressure (mm Hg) – force generated against arterial walls per unit of area in mm Hg.

18. Terms, Definitions & Units Systolic Pressure - peak arterial pressure. Averages about 120 mmHg Diastolic Pressure - lowest arterial pressure. Averages between 70 - 80 mm Hg Blood Volume - quantity of blood in cardiovascular system. Varies from 4-5 L. in females to 5-6 L. in males. Mean arterial pressure- propels the blood to the tissues MAP=diastolic BP+1/3(systolic BP-diastolic BP)

19. Blood Pressure Blood pressure is affected by several factors: – peripheral resistance – vessel elasticity – blood volume – cardiac output

20. Peripheral Resistance Blood cells and plasma encounter resistance when they contact blood vessel walls. If resistance, then more pressure is needed to keep blood moving. Three main sources of peripheral resistance: – blood vessel diameter – blood viscosity – total vessel length F =  P/R

21. Vessel Elasticity Blood Volume Cardiac Output Other Factors Affecting Blood Pressure

22. Velocity of blood flow Velocity is inversely related to the cross- sectional area. – The greater the cross section, the slower the blood. Branching of blood vessels slows velocity. Veins coming together increases velocity

23. Blood flow through tissues Delivers O 2 and nutrients and removes waste Gas exchange Absorption of nutrients from digestive tract Urine formation in the kidney

25. Monitoring Efficiency Pulse – Pressure points Blood Pressure – Blood Pressure Animation Blood Pressure Animation

26. Blood Pressure

27. Monitoring blood pressure Asculatory method uses the sphygmomanometer – Sounds of Korotkoff Brachial artery is compressed and cuff pressure released – First sound is systolic blood pressure – Last sound is the diastolic blood pressure BP has a circadian rhythm—peaks in the morning

28. BP - Stimulates Cardioinhibitory center to heart rate & Vasomotor center to diameter. Homeostatic Blood Pressure Regulation Mechanisms Medullary Reflex Centers: – Cardioacceleratory - increases heart rate – Cardioinhibitory - decreases heart rate – Vasomotor - changes diameter of vessels BP - Stimulates Cardioacceleratory center to heart rate & Vasomotor center to diameter. Baroreceptors in aortic arch & carotid sinuses: –sensitive to changes in blood pressure.

29. in CO 2 or in O 2 stimulates Vasomotor center to diameter (vasoconstrict) of vessels to BP. Homeostatic Blood Pressure Regulation Mechanisms Medullary Reflex Centers: – Cardioacceleratory - increases heart rate – Cardioinhibitory - decreases heart rate – Vasomotor - changes diameter of vessels in CO 2 stimulates Vasomotor center to diameter (vasodilate) of vessels to BP. Chemoreceptors in aortic bodies & carotid bodies: –sensitive to changes in CO 2 & O 2 in blood.

30. Hypertension High blood pressure. Sustained arterial blood pressure of 140/90 mm Hg or above. Rising diastolic pressure generally indicative of progressive hardening of arteries. Since the heart must work harder to pump blood against higher pressures, there is increased risk of a cardiovascular accident.

31. Primary hypertension Diet—high intake of Na +, saturated fats or deficiencies in K +, Ca 2+, or Mg 2+ Obesity Age—over 40 Diabetes mellitus Heredity Stress Smoking

32. Hypotension Abnormally low blood pressure. Sustained systolic blood pressure of below 100 mm Hg. Generally associated with lower risk of cardiovascular accidents & long life providing that the tissues are adequately perfused..

33. Autoregulation of blood pressure

34. Shock and homeostasis Shock is the failure to deliver enough O 2 to meet cellular metabolic needs. Four types of shock 1.Hypovolemic shock—drop in fluid levels 2.Cardiogenic shock—failure of heart to pump 3.Vascular shock—decrease in vascular resistance 4.Obstructive shock—blood flow through a portion of the circulation is blocked.

35. Signs and symptoms of shock Systolic blood pressure below 90mmHg Weak and rapid pulse Rapid heart rate Cool and damp skin Altered mental state Reduced urine formation Thirst Acidosis (low blood pH) Nausea

37. Circulatory Shock Blood vessels inadequately filled to enable normal circulation & supply of O 2 & nutrients. May result in death of cells & damage to organs. Common Types: Hypovolemic - severe blood loss Cardiogenic - heart (pump) failure Vascular - excessive vasodilation Septicemic - vasodilation due to bacterial toxins produced during an infection.

38. Arterial Anatomy Pay attention to position, function and structure or the following: Femoral artery Superior mesenteric artery Brachial artery Common hepatic artery Inferior mesenteric artery Internal iliac artery Aorta Renal artery

39. Venous Anatomy Pay attention to position, function and structure or the following: Great saphenous vein Pulmonary vein Splenic vein. Superior & Inferior mesenteric vein. Hepatic portal vein. Gastroepiploic vein. Superior vena cava Pulmonary trunk External jugular vein

40. Resources Rutgers Blood Vessels