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Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival by Sandra L. Haberichter,

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Presentation on theme: "Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival by Sandra L. Haberichter,"— Presentation transcript:

1 Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival by Sandra L. Haberichter, Michael Balistreri, Pamela Christopherson, Patricia Morateck, Stefana Gavazova, Daniel B. Bellissimo, Marilyn J. Manco-Johnson, Joan Cox Gill, and Robert R. Montgomery Blood Volume 108(10):3344-3351 November 15, 2006 ©2006 by American Society of Hematology

2 Pedigrees and laboratory data of 4 families with type 1 VWD. Pedigrees are shown for 4 families, A, B, C, and D. Affected individuals are represented by half-filled symbols, unaffected individuals by gray symbols, and those with an unknown phenotype are den... Sandra L. Haberichter et al. Blood 2006;108:3344-3351 ©2006 by American Society of Hematology

3 Time course of VWF:Ag, FVIII:C, and VWF:RCo levels after administration of DDAVP or Humate- P. Sandra L. Haberichter et al. Blood 2006;108:3344-3351 ©2006 by American Society of Hematology

4 Plasma VWF multimer pattern obtained by high-resolution SDS-agarose gel electrophoresis for affected and unaffected family members. Sandra L. Haberichter et al. Blood 2006;108:3344-3351 ©2006 by American Society of Hematology

5 Influence of ABO blood group on VWF:Ag, VWFpp, and ratio of VWFpp to VWF:Ag in healthy individuals. Sandra L. Haberichter et al. Blood 2006;108:3344-3351 ©2006 by American Society of Hematology


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