1. Challenge and Innovation in Cardiovascular Therapeutics: 1st Annual BHF Centre Symposium Michael D. Schneider MD FMedSci Head, National Heart and Lung Institute, Imperial College London Director, British Heart Foundation Centre for Research Excellence Simon Marks BHF Chair in Regenerative Cardiology www.imperial.ac.uk/bhfcre Challenge and Innovation in Cardiovascular Therapeutics: 1st Annual BHF Centre Symposium Michael D. Schneider MD FMedSci Head, National Heart and Lung Institute, Imperial College London Director, British Heart Foundation Centre for Research Excellence Simon Marks BHF Chair in Regenerative Cardiology www.imperial.ac.uk/bhfcre

2. BHF Centre for Research Excellence at Imperial

3. BHF Centre - Research Teams Biomedical Sciences Stem Cell & Developmental Biology Regenerative Medicine & Tissue Engineering Vascular Biology, Thrombosis & Inflammation Pulmonary Vascular Disease: Bench to Bedside and Back Electrophysiology & Membrane Biophysics Signal Transduction & Gene Expression Biology of the Failing Heart Cardiac Imaging Applied Physiology & Bioengineering: Clinical Implementation Cardiovascular Epidemiology & Clinical Trials Genetics, Genomics, & Physiology Physical and Computational Sciences Physiological & Pathological Fluid-Tissue Interactions Arterial Pulse Wave Analysis for Clinical Diagnosis Robotics & Minimially Invasive Surgery Bioprocessing & Biomechanics for Tissue Engineering Chemical Biology: Protein-Protein & Protein-Lipid Interactions Chemical Biology: Single-cell Proteomics Chemical Biology: Chemical Genetics Multi-scale Modeling of Bio-systems Systems Biology 11 Life Science teams x 9 Physical Science teams = 99 pairwise combinations

4. Components of Imperial’s BHF Centre New four-year MRes / PhD programme, bespoke curriculum, cross-disciplinary design, dual mentoring Physician-scientist support 7 flagship postdoctoral projects in the Directors’ labs Pump-priming pilot project support Core support posts for animal microsurgery & bioinformatics Core facilities for transgenesis, knockouts Visiting professors — Jason Yuan (‘08), Eric Olson (‘09) Seminar series, specialized workshops –Advanced Optical Methods in Cardiovascular Research BHF Centre as a platform to other funding (e.g. RBHT BRU) Annual Symposium New four-year MRes / PhD programme, bespoke curriculum, cross-disciplinary design, dual mentoring Physician-scientist support 7 flagship postdoctoral projects in the Directors’ labs Pump-priming pilot project support Core support posts for animal microsurgery & bioinformatics Core facilities for transgenesis, knockouts Visiting professors — Jason Yuan (‘08), Eric Olson (‘09) Seminar series, specialized workshops –Advanced Optical Methods in Cardiovascular Research BHF Centre as a platform to other funding (e.g. RBHT BRU) Annual Symposium

5. A vigorous recruitment programme Chair in Developmental Dynamics (offered) Chair in Cardiovascular Genetics (offered) Chair in Cardiovascular Genomics and Systems Biology Chair in Cardiac Surgery Chair in Cardiovascular Stem Cell Biology and Regenerative Medicine Lecturer in Vascular Inflammation Clinical trialists in heart failure and acute ischemic injury Many other posts, awaiting new space… Chair in Developmental Dynamics (offered) Chair in Cardiovascular Genetics (offered) Chair in Cardiovascular Genomics and Systems Biology Chair in Cardiac Surgery Chair in Cardiovascular Stem Cell Biology and Regenerative Medicine Lecturer in Vascular Inflammation Clinical trialists in heart failure and acute ischemic injury Many other posts, awaiting new space…

6. Hammersmith campus development New L Block (£99M), due Xmas 2011 3 cardiovascular floors, 60,000 sq ft, 250-300 researchers Adjacent to MRC CSC and WT Clinical Research Facility Large-mammal cath lab (BHF) & imaging suite, April 2010 New L Block (£99M), due Xmas 2011 3 cardiovascular floors, 60,000 sq ft, 250-300 researchers Adjacent to MRC CSC and WT Clinical Research Facility Large-mammal cath lab (BHF) & imaging suite, April 2010

7. A few housekeeping details