1. SyBIT Tools for SystemsX.ch Ela Hunt and Peter Kunszt, SyBIT, SystemsX.ch, ETH Zurich {ela.hunt, peter.kunszt}@systemsx.ch SystemsX.ch is a consortium encompassing nine universities and three research institutions. It is funded with a federal budget of CHF 100 Mio for the period of 2008 – 2011, matched by the same amount by the partners receiving funds. SystemsX.ch supports about 750 researchers from 250 research groups in 62 projects. https://wiki.systemsx.ch/display/SYBIT/https://wiki.systemsx.ch/display/SYBIT/, http://ww.sybit.nethttp://ww.sybit.net The portal administrators together with the advanced users develop and publish workflow (WF) templates. The scientific users access the workflows via a friendly interface and focus on the results. WORKFLOWS AND CLOUDS FOR PROTEOMICS AND NGS iBRAIN2 AND openBIS FOR HCS P-GRADE OpenBIS Computing Clusters Computing Clusters Configure WF ADMIN Choose data+WF SCIENTIST Results Step 1: the workflow processes the inputs in parallel using X!Tandem, OMSSA and Mascot. Step 2: the workflow combines the results from each parameter set using ProteinProphet and Spectrast. The results are exported into OpenBIS. OpenBIS DataStoreServer iBRAIN2 Workflow Manager OpenBIS Web Application iBRAIN2 Status Monitor Cluster + Cluster FS Acquire data manage stored data request data store results browse data monitor workflows retrieve data stage data iBRAIN2 together with openBIS support high content screening (HCS). HCS experiments produce TB-sized data. Images are compressed, transferred to a database, sent to a computing cluster for analysis, and the results are brought back to the database. The software replicates the functionality of iBRAIN, http://www.imsb.ethz.ch/researchgroup/plucas/Software/iBRAIN, in a portable and reconfigurable Java and DB-based platform.http://www.imsb.ethz.ch/researchgroup/plucas/Software/iBRAIN openBIS FOR HCS, NGS, PROTEOMICS AND METABOLOMICS Merged channels Cy3 DAPI GFP http://www.cisd.ethz.ch/software/openBIS http://www.cisd.ethz.ch/software/openBIS provides high volume image and metadata storage and search functions and supports image and data analysis for HCS, NGS, proteomics and metabolomics in the lab via a range of visualisation options. Video material on openBIS is available. Ela HuntPeter Kunszt PS 281 IBM Cloud Data Centers IMSB CloudBroker IBM Platform Client … Rosetta Instances Storage Instance input file download result file upload number crunching job steering Instance allocation and deallocation Client request result file download Input file upload Strep pneumoniae protein 3D modelling: the CloudBroker Platform manages the data placement and steers Rosetta instance allocations and deallocations FMI NGS pipeline. SyBIT Team Recent publications 1. P Kunszt, L Espona Pernas, A Quandt, E Schmid, E Hunt, L Malmstrom (2011). The Swiss Grid Proteomics Portal. PARENG'11. Civil-Comp Press, Stirlingshire, UK, Paper 81, 2011.The Swiss Grid Proteomics Portal 2. K Kozak, A Bauch, T Pylak, B Rinn (2010). Towards a comprehensive open source platform for management and analysis of High Content Screening data. European Pharmaceutical Review, 4:34-38.Towards a comprehensive open source platform for management and analysis of High Content Screening data 3. R Murri, P Kunszt, S Maffioletti, V Tschopp. GridCertLib: a Single Sign-on Solution for Grid Web Portals, to appear in Journal of Grid Computing.GridCertLib: a Single Sign-on Solution for Grid Web Portals